ENSG00000186908

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000426126 ENSG00000186908 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC17 protein_coding protein_coding 9.521716 1.763691 20.30012 0.2029537 0.1603047 3.517372 5.9024802 0.9066147 13.1114577 0.14238036 0.52954737 3.83946878 0.52661250 0.51356667 0.64606667 0.1325000000 0.4378794655 0.0004242235 FALSE TRUE
ENST00000549010 ENSG00000186908 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC17 protein_coding processed_transcript 9.521716 1.763691 20.30012 0.2029537 0.1603047 3.517372 0.2459335 0.2715364 0.2551926 0.10871915 0.07777517 -0.08628067 0.05887917 0.16123333 0.01260000 -0.1486333333 0.0053956595 0.0004242235   FALSE
ENST00000550244 ENSG00000186908 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC17 protein_coding retained_intron 9.521716 1.763691 20.30012 0.2029537 0.1603047 3.517372 0.4938986 0.3561511 0.7666355 0.12894382 0.30532428 1.08479859 0.18565000 0.19186667 0.03793333 -0.1539333333 0.0245584639 0.0004242235 FALSE TRUE
ENST00000552453 ENSG00000186908 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC17 protein_coding nonsense_mediated_decay 9.521716 1.763691 20.30012 0.2029537 0.1603047 3.517372 0.9669740 0.0000000 2.3338116 0.00000000 0.48739130 7.87271282 0.05969167 0.00000000 0.11466667 0.1146666667 0.0004242235 0.0004242235 TRUE TRUE
ENST00000552693 ENSG00000186908 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC17 protein_coding retained_intron 9.521716 1.763691 20.30012 0.2029537 0.1603047 3.517372 0.8797416 0.1643754 1.8972725 0.01033497 0.13519114 3.45124217 0.08679167 0.09436667 0.09353333 -0.0008333333 1.0000000000 0.0004242235   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000186908 E001 0.3206185 0.0274424043 1.000000e+00   12 76764103 76764114 12 + 0.075 0.000 -7.772
ENSG00000186908 E002 2.5318116 0.0307565845 2.106471e-01 0.4425783178 12 76764115 76764243 129 + 0.400 0.000 -12.295
ENSG00000186908 E003 3.0469821 0.2051005092 2.336705e-01 0.4693836040 12 76764244 76764252 9 + 0.448 0.000 -12.014
ENSG00000186908 E004 3.0469821 0.2051005092 2.336705e-01 0.4693836040 12 76764253 76764253 1 + 0.448 0.000 -12.014
ENSG00000186908 E005 3.4936671 0.1146575678 1.465968e-01 0.3573323241 12 76764254 76764257 4 + 0.488 0.000 -12.378
ENSG00000186908 E006 34.6399119 0.0012153587 1.832645e-03 0.0159324909 12 76764258 76764297 40 + 1.318 0.939 -1.363
ENSG00000186908 E007 37.0723146 0.0013526049 7.058559e-04 0.0074937839 12 76764298 76764329 32 + 1.348 0.939 -1.469
ENSG00000186908 E008 0.0000000       12 76764573 76764812 240 +      
ENSG00000186908 E009 0.0000000       12 76769073 76769201 129 +      
ENSG00000186908 E010 0.0000000       12 76781625 76781628 4 +      
ENSG00000186908 E011 0.0000000       12 76781629 76781683 55 +      
ENSG00000186908 E012 46.9423159 0.0009791588 1.278708e-01 0.3284761546 12 76797434 76797518 85 + 1.435 1.318 -0.406
ENSG00000186908 E013 30.8662739 0.0011434835 5.404808e-01 0.7293522732 12 76797519 76797537 19 + 1.254 1.215 -0.139
ENSG00000186908 E014 56.2013717 0.0040797487 9.884992e-01 0.9960240681 12 76805317 76805439 123 + 1.501 1.531 0.101
ENSG00000186908 E015 38.5913423 0.0038272071 7.372308e-01 0.8587288917 12 76809043 76809120 78 + 1.340 1.401 0.210
ENSG00000186908 E016 54.6024456 0.0007071650 4.116076e-01 0.6372660848 12 76809713 76809857 145 + 1.494 1.454 -0.137
ENSG00000186908 E017 0.0000000       12 76813313 76813449 137 +      
ENSG00000186908 E018 45.8084754 0.0010306971 1.895294e-02 0.0922776696 12 76815146 76815210 65 + 1.428 1.214 -0.744
ENSG00000186908 E019 33.6699744 0.0010540764 3.344927e-01 0.5730714148 12 76815857 76815897 41 + 1.291 1.215 -0.270
ENSG00000186908 E020 63.3105994 0.0006113960 2.559006e-02 0.1140303799 12 76815898 76816019 122 + 1.562 1.401 -0.554
ENSG00000186908 E021 7.9830128 0.0039640570 9.088983e-01 0.9565198621 12 76821058 76821167 110 + 0.729 0.732 0.014
ENSG00000186908 E022 58.7959237 0.0006914458 7.389778e-03 0.0464987346 12 76822406 76822531 126 + 1.534 1.318 -0.748
ENSG00000186908 E023 47.0538379 0.0008208849 5.786463e-03 0.0386818805 12 76826908 76827050 143 + 1.444 1.184 -0.907
ENSG00000186908 E024 46.0168583 0.0009726198 7.876534e-03 0.0487522925 12 76828390 76828490 101 + 1.435 1.184 -0.876
ENSG00000186908 E025 2.4546028 0.2759814701 4.602583e-03 0.0324869504 12 76840059 76840390 332 + 0.223 0.992 3.711
ENSG00000186908 E026 1.8613620 0.0580345396 7.936862e-02 0.2435425036 12 76840391 76840483 93 + 0.246 0.634 2.113
ENSG00000186908 E027 0.1614157 0.0345366881 5.400726e-01   12 76840965 76841106 142 + 0.039 0.000 -8.522
ENSG00000186908 E028 30.6678479 0.0011952432 5.384630e-01 0.7279589472 12 76841982 76842024 43 + 1.254 1.214 -0.139
ENSG00000186908 E029 43.5972689 0.0009596950 2.433928e-01 0.4804645313 12 76842025 76842106 82 + 1.402 1.318 -0.293
ENSG00000186908 E030 43.4805878 0.0124852742 3.532694e-01 0.5901887448 12 76842919 76842981 63 + 1.398 1.319 -0.275
ENSG00000186908 E031 27.5262725 0.0231316811 6.946744e-01 0.8320942067 12 76843914 76844874 961 + 1.197 1.268 0.252
ENSG00000186908 E032 8.3745881 0.0041730508 4.810541e-01 0.6878175351 12 76844875 76844947 73 + 0.736 0.880 0.567
ENSG00000186908 E033 21.7427811 0.0017804523 4.436671e-01 0.6611453530 12 76844948 76845708 761 + 1.096 1.215 0.425
ENSG00000186908 E034 44.6183118 0.0010443406 2.715129e-01 0.5113771593 12 76845709 76845802 94 + 1.394 1.517 0.423
ENSG00000186908 E035 3.0252860 0.0084402003 6.029466e-01 0.7721977811 12 76846291 76846595 305 + 0.432 0.322 -0.634
ENSG00000186908 E036 39.6458183 0.0010477318 2.890364e-01 0.5295725830 12 76846596 76846679 84 + 1.346 1.471 0.430
ENSG00000186908 E037 25.1028619 0.0018080900 9.115879e-01 0.9579502048 12 76848233 76848237 5 + 1.168 1.184 0.057
ENSG00000186908 E038 66.3966002 0.0008053108 2.019855e-01 0.4320505386 12 76848238 76848390 153 + 1.564 1.683 0.407
ENSG00000186908 E039 52.1801760 0.0007881692 2.345862e-01 0.4703794610 12 76849376 76849470 95 + 1.461 1.584 0.420
ENSG00000186908 E040 1.2868997 0.0136781315 6.058001e-01   12 76849471 76849669 199 + 0.245 0.000 -11.522
ENSG00000186908 E041 526.0664428 0.0035401773 1.158877e-05 0.0002380597 12 76850847 76853696 2850 + 2.446 2.594 0.491