ENSG00000186815

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335509 ENSG00000186815 HEK293_OSMI2_6hA HEK293_TMG_6hB TPCN1 protein_coding protein_coding 12.75925 18.68541 8.622597 1.412833 0.4290674 -1.114817 3.2924176 5.373266 1.7803700 1.5833811 0.45705763 -1.58822385 0.26521667 0.30143333 0.204766667 -0.09666667 8.694023e-01 4.110236e-05 FALSE TRUE
ENST00000541517 ENSG00000186815 HEK293_OSMI2_6hA HEK293_TMG_6hB TPCN1 protein_coding protein_coding 12.75925 18.68541 8.622597 1.412833 0.4290674 -1.114817 3.0657191 3.343094 3.4819505 0.5506357 0.32758153 0.05854035 0.24658333 0.17730000 0.408466667 0.23116667 1.794685e-02 4.110236e-05 FALSE TRUE
ENST00000546787 ENSG00000186815 HEK293_OSMI2_6hA HEK293_TMG_6hB TPCN1 protein_coding processed_transcript 12.75925 18.68541 8.622597 1.412833 0.4290674 -1.114817 1.2949621 1.495611 0.0486538 0.5289747 0.02485700 -4.68198085 0.09204583 0.08256667 0.005833333 -0.07673333 5.213563e-02 4.110236e-05 FALSE TRUE
ENST00000550543 ENSG00000186815 HEK293_OSMI2_6hA HEK293_TMG_6hB TPCN1 protein_coding retained_intron 12.75925 18.68541 8.622597 1.412833 0.4290674 -1.114817 0.9108783 1.089944 1.1537368 0.7245118 0.27462321 0.08133426 0.07384583 0.05470000 0.131666667 0.07696667 4.121121e-01 4.110236e-05   FALSE
ENST00000550785 ENSG00000186815 HEK293_OSMI2_6hA HEK293_TMG_6hB TPCN1 protein_coding protein_coding 12.75925 18.68541 8.622597 1.412833 0.4290674 -1.114817 0.9712412 2.614154 0.1785668 0.6343412 0.01211651 -3.79870428 0.06970417 0.13673333 0.020866667 -0.11586667 4.110236e-05 4.110236e-05 FALSE TRUE
ENST00000551127 ENSG00000186815 HEK293_OSMI2_6hA HEK293_TMG_6hB TPCN1 protein_coding retained_intron 12.75925 18.68541 8.622597 1.412833 0.4290674 -1.114817 1.0233433 1.399500 0.7589800 0.5735853 0.03489135 -0.87416542 0.07865000 0.07176667 0.088500000 0.01673333 8.536146e-01 4.110236e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000186815 E001 0.0000000       12 113221050 113221073 24 +      
ENSG00000186815 E002 0.0000000       12 113221074 113221079 6 +      
ENSG00000186815 E003 0.0000000       12 113221080 113221231 152 +      
ENSG00000186815 E004 0.0000000       12 113221232 113221236 5 +      
ENSG00000186815 E005 0.0000000       12 113221237 113221378 142 +      
ENSG00000186815 E006 0.0000000       12 113221429 113221437 9 +      
ENSG00000186815 E007 0.1723744 0.0311142626 1.0000000000   12 113221438 113221445 8 + 0.000 0.081 14.240
ENSG00000186815 E008 0.4756169 0.0244411696 0.3689853521   12 113221446 113221459 14 + 0.000 0.207 18.191
ENSG00000186815 E009 0.4756169 0.0244411696 0.3689853521   12 113221460 113221463 4 + 0.000 0.207 18.191
ENSG00000186815 E010 3.4041422 0.0262288849 0.0633823384 0.210316318 12 113221464 113221485 22 + 0.305 0.672 1.861
ENSG00000186815 E011 15.1153283 0.0021478040 0.0008528341 0.008713203 12 113221486 113221583 98 + 0.853 1.243 1.430
ENSG00000186815 E012 16.6052568 0.0040260876 0.0065869851 0.042643396 12 113221584 113221626 43 + 0.963 1.268 1.100
ENSG00000186815 E013 5.1880080 0.0060441966 0.0019903239 0.017001264 12 113225244 113225245 2 + 0.306 0.864 2.627
ENSG00000186815 E014 12.6846081 0.0120682215 0.2181376595 0.451204499 12 113225246 113225336 91 + 0.963 1.135 0.628
ENSG00000186815 E015 77.4764059 0.0005340680 0.1950745597 0.423454897 12 113226728 113226964 237 + 1.875 1.840 -0.118
ENSG00000186815 E016 1.3926716 0.0136276742 0.3086692377 0.549222984 12 113244261 113244361 101 + 0.179 0.385 1.484
ENSG00000186815 E017 1.3511654 0.0205816510 0.3111208741   12 113244368 113244502 135 + 0.179 0.385 1.482
ENSG00000186815 E018 1.7191344 0.1209588047 0.2137746111 0.446086354 12 113244503 113244743 241 + 0.179 0.480 1.980
ENSG00000186815 E019 2.7810366 0.0139535823 0.3569387497 0.593243255 12 113245912 113246063 152 + 0.404 0.586 0.898
ENSG00000186815 E020 0.1723744 0.0311142626 1.0000000000   12 113260302 113260367 66 + 0.000 0.081 16.603
ENSG00000186815 E021 67.8667798 0.0042558220 0.4146980819 0.639590159 12 113260368 113260492 125 + 1.812 1.788 -0.081
ENSG00000186815 E022 71.3431925 0.0064864245 0.9366755909 0.970544152 12 113266180 113266356 177 + 1.803 1.819 0.052
ENSG00000186815 E023 52.2690121 0.0029908395 0.4078418651 0.634336755 12 113267843 113267956 114 + 1.700 1.672 -0.093
ENSG00000186815 E024 55.1390178 0.0012050547 0.7415436626 0.861430385 12 113268742 113268872 131 + 1.699 1.702 0.010
ENSG00000186815 E025 48.9218335 0.0020735475 0.6520032454 0.804764601 12 113269757 113269845 89 + 1.652 1.647 -0.019
ENSG00000186815 E026 44.3072504 0.0039125423 0.2685441776 0.508207070 12 113272658 113272692 35 + 1.642 1.594 -0.164
ENSG00000186815 E027 59.0597176 0.0061278131 0.0512793154 0.182799958 12 113273232 113273290 59 + 1.797 1.704 -0.317
ENSG00000186815 E028 81.7639020 0.0034135707 0.0023545578 0.019406817 12 113273569 113273668 100 + 1.956 1.831 -0.423
ENSG00000186815 E029 0.0000000       12 113276918 113276918 1 +      
ENSG00000186815 E030 76.0046414 0.0006450076 0.0177132167 0.088049163 12 113276919 113277002 84 + 1.898 1.816 -0.278
ENSG00000186815 E031 46.3095778 0.0009485664 0.3082035499 0.548827168 12 113277003 113277035 33 + 1.657 1.621 -0.123
ENSG00000186815 E032 37.0713775 0.0012430272 0.5237513202 0.717640010 12 113277240 113277252 13 + 1.547 1.527 -0.067
ENSG00000186815 E033 72.1665298 0.0025584238 0.3398002142 0.577804515 12 113277253 113277364 112 + 1.838 1.810 -0.094
ENSG00000186815 E034 57.3703845 0.0006920791 0.3784135274 0.610856452 12 113278189 113278237 49 + 1.737 1.714 -0.079
ENSG00000186815 E035 58.3120194 0.0006196051 0.0229279170 0.105706194 12 113278772 113278835 64 + 1.791 1.700 -0.307
ENSG00000186815 E036 52.0493051 0.0007730662 0.0015726971 0.014128536 12 113280151 113280195 45 + 1.776 1.633 -0.484
ENSG00000186815 E037 1.6533781 0.0118792760 0.1395273270 0.346772271 12 113280196 113280314 119 + 0.551 0.305 -1.324
ENSG00000186815 E038 57.2414374 0.0006305118 0.0242800755 0.109962978 12 113284581 113284624 44 + 1.784 1.693 -0.307
ENSG00000186815 E039 45.3643667 0.0008136801 0.3630571496 0.598210455 12 113284625 113284637 13 + 1.642 1.612 -0.103
ENSG00000186815 E040 0.6536007 0.0194460749 0.9332102467   12 113284716 113284717 2 + 0.179 0.207 0.258
ENSG00000186815 E041 63.2830239 0.0008056794 0.5753133092 0.753886526 12 113284718 113284771 54 + 1.765 1.759 -0.019
ENSG00000186815 E042 68.4819824 0.0012161002 0.7174867394 0.846587024 12 113285889 113285961 73 + 1.794 1.799 0.015
ENSG00000186815 E043 74.0857459 0.0185888420 0.7707494275 0.879106058 12 113286987 113287094 108 + 1.802 1.840 0.129
ENSG00000186815 E044 12.8335324 0.2254243739 0.0597425729 0.202197480 12 113287095 113287404 310 + 1.283 0.993 -1.039
ENSG00000186815 E045 62.7111014 0.0040152164 0.9146006574 0.959394588 12 113288163 113288234 72 + 1.749 1.765 0.054
ENSG00000186815 E046 14.6146494 0.1699157967 0.6673011371 0.814506336 12 113288235 113288494 260 + 1.139 1.155 0.057
ENSG00000186815 E047 10.2780256 0.0853949807 0.5555130299 0.740127955 12 113288495 113288526 32 + 1.031 1.001 -0.113
ENSG00000186815 E048 20.4242423 0.0728020147 0.7534443838 0.868801987 12 113288527 113288757 231 + 1.281 1.284 0.011
ENSG00000186815 E049 73.7308160 0.0006279106 0.8235898498 0.910031095 12 113288758 113288847 90 + 1.819 1.830 0.040
ENSG00000186815 E050 0.6370325 0.0193874923 0.9335021954   12 113290049 113290127 79 + 0.179 0.207 0.259
ENSG00000186815 E051 90.1570603 0.0006186821 0.1261041211 0.325659674 12 113290128 113290243 116 + 1.944 1.903 -0.135
ENSG00000186815 E052 70.2767287 0.0036013143 0.4124817934 0.637962274 12 113290952 113290998 47 + 1.822 1.803 -0.064
ENSG00000186815 E053 90.2818712 0.0011008172 0.6831506850 0.824656741 12 113291609 113291677 69 + 1.884 1.924 0.135
ENSG00000186815 E054 1.2848361 0.0138651394 0.0472277711   12 113291678 113291873 196 + 0.000 0.420 19.594
ENSG00000186815 E055 105.5299505 0.0004535262 0.6209912995 0.784527986 12 113291874 113291958 85 + 1.954 1.995 0.138
ENSG00000186815 E056 34.3287793 0.1115641506 0.3015044042 0.542012927 12 113291959 113292933 975 + 1.551 1.483 -0.234
ENSG00000186815 E057 86.6810709 0.0032120407 0.0766969956 0.238163321 12 113292934 113293018 85 + 1.818 1.929 0.371
ENSG00000186815 E058 54.8652636 0.0007647372 0.0949945288 0.272956175 12 113293019 113293073 55 + 1.616 1.729 0.383
ENSG00000186815 E059 68.4932434 0.0013753162 0.1717246610 0.392839015 12 113293269 113293349 81 + 1.725 1.815 0.304
ENSG00000186815 E060 1.8271575 0.0300087458 0.9996079982 1.000000000 12 113294106 113294228 123 + 0.404 0.421 0.091
ENSG00000186815 E061 773.4432524 0.0073569049 0.0101984360 0.058969322 12 113295960 113298585 2626 + 2.764 2.870 0.350