ENSG00000186615

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335142 ENSG00000186615 HEK293_OSMI2_6hA HEK293_TMG_6hB KTN1-AS1 lncRNA lncRNA 2.972002 2.674446 2.325814 0.3942626 0.2359042 -0.2006989 0.4032458 0.64158881 0.1840124 0.035558740 0.11680746 -1.7478133 0.1550500 0.24720000 0.08166667 -0.16553333 4.355017e-01 4.337028e-12   FALSE
ENST00000412224 ENSG00000186615 HEK293_OSMI2_6hA HEK293_TMG_6hB KTN1-AS1 lncRNA lncRNA 2.972002 2.674446 2.325814 0.3942626 0.2359042 -0.2006989 1.0102785 0.36599058 1.3434962 0.081549639 0.02999441 1.8479224 0.3490917 0.14253333 0.59356667 0.45103333 1.353799e-03 4.337028e-12 FALSE FALSE
ENST00000554558 ENSG00000186615 HEK293_OSMI2_6hA HEK293_TMG_6hB KTN1-AS1 lncRNA lncRNA 2.972002 2.674446 2.325814 0.3942626 0.2359042 -0.2006989 0.1776731 0.06845584 0.3058022 0.009241113 0.01227311 2.0090683 0.0624125 0.02576667 0.13366667 0.10790000 1.445316e-02 4.337028e-12   FALSE
ENST00000663686 ENSG00000186615 HEK293_OSMI2_6hA HEK293_TMG_6hB KTN1-AS1 lncRNA lncRNA 2.972002 2.674446 2.325814 0.3942626 0.2359042 -0.2006989 0.8960741 0.52458013 0.4080598 0.353782302 0.23315482 -0.3546969 0.2762167 0.17310000 0.15793333 -0.01516667 1.000000e+00 4.337028e-12 FALSE FALSE
MSTRG.9603.3 ENSG00000186615 HEK293_OSMI2_6hA HEK293_TMG_6hB KTN1-AS1 lncRNA   2.972002 2.674446 2.325814 0.3942626 0.2359042 -0.2006989 0.4099350 1.05673601 0.0000000 0.087608641 0.00000000 -6.7370594 0.1293583 0.40373333 0.00000000 -0.40373333 4.337028e-12 4.337028e-12   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000186615 E001 9.8403425 0.003499924 5.901164e-05 9.603770e-04 14 55496786 55499493 2708 - 1.178 0.750 -1.606
ENSG00000186615 E002 0.8267829 0.019995750 8.018120e-01   14 55513761 55515617 1857 - 0.274 0.233 -0.306
ENSG00000186615 E003 0.0000000       14 55517509 55517673 165 -      
ENSG00000186615 E004 1.0172733 0.022612219 8.726868e-01   14 55557972 55557985 14 - 0.337 0.314 -0.143
ENSG00000186615 E005 32.3277320 0.002805547 2.707068e-09 1.442946e-07 14 55557986 55559774 1789 - 1.647 1.319 -1.128
ENSG00000186615 E006 9.2874856 0.004204312 1.628775e-02 8.284766e-02 14 55561089 55561163 75 - 1.114 0.868 -0.911
ENSG00000186615 E007 0.2027342 0.032887732 4.125173e-01   14 55576186 55576186 1 - 0.000 0.132 10.292
ENSG00000186615 E008 8.1804686 0.045843821 2.023617e-02 9.669577e-02 14 55576187 55577139 953 - 0.794 1.114 1.202
ENSG00000186615 E009 9.8522658 0.029501166 9.239873e-04 9.292567e-03 14 55577140 55577379 240 - 0.777 1.200 1.576
ENSG00000186615 E010 24.1023820 0.001723914 1.649674e-02 8.363514e-02 14 55578606 55578737 132 - 1.315 1.474 0.552
ENSG00000186615 E011 0.2922838 0.027943272 9.020895e-01   14 55579202 55579322 121 - 0.112 0.132 0.275
ENSG00000186615 E012 18.2037601 0.002472571 3.119082e-06 7.684488e-05 14 55579936 55580143 208 - 1.074 1.436 1.278
ENSG00000186615 E013 0.1426347 0.031165501 5.708690e-01   14 55580846 55580888 43 - 0.111 0.000 -10.681