ENSG00000186575

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338641 ENSG00000186575 HEK293_OSMI2_6hA HEK293_TMG_6hB NF2 protein_coding protein_coding 21.6372 31.40461 13.58837 5.519552 0.3896107 -1.208002 10.4965725 16.3550406 7.8562619 2.89459612 0.6833196 -1.0568671 0.50307083 0.520633333 0.57653333 0.0559000 7.494643e-01 5.321248e-06 FALSE TRUE
ENST00000361452 ENSG00000186575 HEK293_OSMI2_6hA HEK293_TMG_6hB NF2 protein_coding protein_coding 21.6372 31.40461 13.58837 5.519552 0.3896107 -1.208002 2.0322900 3.1223512 0.4510849 1.34559284 0.2311297 -2.7641417 0.07895417 0.090166667 0.03356667 -0.0566000 6.801065e-01 5.321248e-06 FALSE TRUE
ENST00000397789 ENSG00000186575 HEK293_OSMI2_6hA HEK293_TMG_6hB NF2 protein_coding protein_coding 21.6372 31.40461 13.58837 5.519552 0.3896107 -1.208002 0.8441783 0.2545008 2.1708859 0.07857903 0.6510511 3.0435704 0.05712083 0.009833333 0.16123333 0.1514000 5.830634e-04 5.321248e-06 FALSE TRUE
ENST00000413209 ENSG00000186575 HEK293_OSMI2_6hA HEK293_TMG_6hB NF2 protein_coding protein_coding 21.6372 31.40461 13.58837 5.519552 0.3896107 -1.208002 1.9621035 2.7382227 0.0220887 1.01970994 0.0220887 -6.4202899 0.06221250 0.081900000 0.00170000 -0.0802000 5.321248e-06 5.321248e-06 FALSE TRUE
ENST00000672461 ENSG00000186575 HEK293_OSMI2_6hA HEK293_TMG_6hB NF2 protein_coding nonsense_mediated_decay 21.6372 31.40461 13.58837 5.519552 0.3896107 -1.208002 1.9811785 0.8177055 0.0000000 0.81770554 0.0000000 -6.3710457 0.06929167 0.022300000 0.00000000 -0.0223000 9.540346e-01 5.321248e-06 TRUE TRUE
ENST00000672805 ENSG00000186575 HEK293_OSMI2_6hA HEK293_TMG_6hB NF2 protein_coding nonsense_mediated_decay 21.6372 31.40461 13.58837 5.519552 0.3896107 -1.208002 1.0291748 0.8445248 1.0004691 0.14883223 0.1223646 0.2418309 0.06266250 0.026966667 0.07346667 0.0465000 2.923860e-03 5.321248e-06 FALSE TRUE
ENST00000672896 ENSG00000186575 HEK293_OSMI2_6hA HEK293_TMG_6hB NF2 protein_coding protein_coding 21.6372 31.40461 13.58837 5.519552 0.3896107 -1.208002 2.3267931 6.3546506 0.6801285 0.41217633 0.4233812 -3.2051444 0.11131667 0.217066667 0.05070000 -0.1663667 4.179352e-01 5.321248e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000186575 E001 2.6892742 0.0225829461 2.051684e-01 4.361122e-01 22 29603556 29603567 12 + 0.314 0.575 1.381
ENSG00000186575 E002 4.2539626 0.0067310278 6.621052e-02 2.165429e-01 22 29603568 29603587 20 + 0.413 0.756 1.566
ENSG00000186575 E003 6.5037092 0.0047838148 1.248335e-02 6.836731e-02 22 29603588 29603602 15 + 0.494 0.917 1.775
ENSG00000186575 E004 7.7111424 0.0074083317 9.787109e-03 5.720430e-02 22 29603603 29603616 14 + 0.562 0.982 1.699
ENSG00000186575 E005 11.1115853 0.0030353432 4.783779e-04 5.480273e-03 22 29603617 29603632 16 + 0.621 1.126 1.959
ENSG00000186575 E006 45.1794777 0.0008563085 2.751966e-03 2.188364e-02 22 29603633 29603726 94 + 1.439 1.664 0.769
ENSG00000186575 E007 41.5141290 0.0009265444 2.936110e-03 2.301602e-02 22 29603727 29603746 20 + 1.395 1.628 0.797
ENSG00000186575 E008 83.6057652 0.0005882265 1.395512e-02 7.416365e-02 22 29603747 29603948 202 + 1.765 1.912 0.496
ENSG00000186575 E009 45.8755978 0.0033676619 6.983528e-01 8.345099e-01 22 29603949 29603998 50 + 1.580 1.635 0.186
ENSG00000186575 E010 76.0043114 0.0005407461 7.848478e-03 4.862117e-02 22 29603999 29604085 87 + 1.897 1.812 -0.288
ENSG00000186575 E011 67.8690213 0.0006362338 5.903389e-03 3.926721e-02 22 29604086 29604112 27 + 1.857 1.761 -0.324
ENSG00000186575 E012 10.8632171 0.0032754225 3.271249e-01 5.662257e-01 22 29628658 29628773 116 + 1.084 1.009 -0.272
ENSG00000186575 E013 127.9234735 0.0004116294 2.555616e-09 1.372123e-07 22 29636751 29636876 126 + 2.177 2.010 -0.561
ENSG00000186575 E014 112.6952320 0.0003657285 8.727137e-09 4.157275e-07 22 29639090 29639212 123 + 2.122 1.949 -0.579
ENSG00000186575 E015 99.6997475 0.0005355746 2.701693e-05 4.927608e-04 22 29642202 29642285 84 + 2.040 1.909 -0.438
ENSG00000186575 E016 98.0022562 0.0005059661 1.551302e-06 4.169782e-05 22 29654657 29654725 69 + 2.048 1.894 -0.516
ENSG00000186575 E017 0.3206185 0.0274424043 3.779584e-02   22 29654975 29655080 106 + 0.314 0.000 -10.733
ENSG00000186575 E018 103.0336789 0.0005172314 1.707569e-04 2.342363e-03 22 29655594 29655676 83 + 2.042 1.930 -0.376
ENSG00000186575 E019 120.0457535 0.0004819553 3.720834e-09 1.919451e-07 22 29658189 29658264 76 + 2.149 1.975 -0.584
ENSG00000186575 E020 167.2552611 0.0003668567 5.901261e-08 2.315549e-06 22 29661205 29661339 135 + 2.264 2.135 -0.431
ENSG00000186575 E021 128.8037945 0.0004151750 1.346950e-08 6.134165e-07 22 29664990 29665064 75 + 2.170 2.011 -0.532
ENSG00000186575 E022 174.0501692 0.0002698290 8.070014e-09 3.874679e-07 22 29668333 29668446 114 + 2.285 2.151 -0.449
ENSG00000186575 E023 161.8058049 0.0002875596 5.292265e-04 5.942530e-03 22 29671826 29671912 87 + 2.211 2.138 -0.246
ENSG00000186575 E024 124.8130533 0.0003803625 1.291523e-01 3.304411e-01 22 29671913 29671948 36 + 2.060 2.039 -0.072
ENSG00000186575 E025 229.2706540 0.0002660870 1.969443e-04 2.640378e-03 22 29673269 29673486 218 + 2.356 2.292 -0.212
ENSG00000186575 E026 161.1780124 0.0003016995 1.099398e-03 1.066509e-02 22 29674836 29674941 106 + 2.207 2.139 -0.226
ENSG00000186575 E027 183.7561416 0.0002462540 3.804612e-05 6.604423e-04 22 29678196 29678323 128 + 2.273 2.188 -0.284
ENSG00000186575 E028 185.5059899 0.0002627007 2.551784e-03 2.066827e-02 22 29681439 29681601 163 + 2.256 2.202 -0.180
ENSG00000186575 E029 36.0879437 0.0010154644 1.000807e-02 5.820201e-02 22 29683020 29683064 45 + 1.346 1.563 0.746
ENSG00000186575 E030 2.7295672 0.2445342679 5.169877e-01 7.130036e-01 22 29683065 29683079 15 + 0.673 0.471 -0.922
ENSG00000186575 E031 6.3051037 0.1875059092 9.520032e-01 9.779540e-01 22 29683080 29683700 621 + 0.803 0.819 0.064
ENSG00000186575 E032 6.1411854 0.0830073495 5.449931e-01 7.326585e-01 22 29683701 29684162 462 + 0.867 0.786 -0.316
ENSG00000186575 E033 307.4308624 0.0001804550 4.082842e-01 6.346997e-01 22 29694752 29695243 492 + 2.396 2.448 0.174
ENSG00000186575 E034 1013.9979285 0.0001727129 1.697171e-15 2.758073e-13 22 29695244 29697260 2017 + 2.849 2.985 0.452
ENSG00000186575 E035 969.5587610 0.0027240498 6.429235e-22 2.368399e-19 22 29697261 29698598 1338 + 2.708 2.993 0.946