ENSG00000186480

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340368 ENSG00000186480 HEK293_OSMI2_6hA HEK293_TMG_6hB INSIG1 protein_coding protein_coding 46.67115 27.02423 67.74944 2.550307 2.105849 1.325634 34.664395 22.3171726 48.972858 2.6033929 0.82023997 1.133476 0.74987500 0.82190000 0.72360000 -0.09830000 1.408548e-01 2.291611e-05 FALSE  
ENST00000476756 ENSG00000186480 HEK293_OSMI2_6hA HEK293_TMG_6hB INSIG1 protein_coding protein_coding 46.67115 27.02423 67.74944 2.550307 2.105849 1.325634 6.736799 0.7314229 13.530016 0.3657327 1.27395553 4.190789 0.13057083 0.02903333 0.19890000 0.16986667 2.949742e-01 2.291611e-05 FALSE  
MSTRG.30968.5 ENSG00000186480 HEK293_OSMI2_6hA HEK293_TMG_6hB INSIG1 protein_coding   46.67115 27.02423 67.74944 2.550307 2.105849 1.325634 1.437008 2.1278711 1.502196 0.1989850 0.06016697 -0.499530 0.03354583 0.08036667 0.02223333 -0.05813333 2.291611e-05 2.291611e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000186480 E001 0.0000000       7 155295884 155295948 65 +      
ENSG00000186480 E002 0.0000000       7 155295949 155297775 1827 +      
ENSG00000186480 E003 0.3926045 0.460042528 0.1345051089   7 155297776 155297828 53 + 0.000 0.321 10.953
ENSG00000186480 E004 1.3530885 0.147610668 0.4298378690   7 155297829 155297862 34 + 0.315 0.463 0.834
ENSG00000186480 E005 5.9985626 0.025497504 0.0072180053 0.045661513 7 155297863 155297877 15 + 0.675 1.013 1.321
ENSG00000186480 E006 58.0240510 0.383430122 0.0977092254 0.277774757 7 155297878 155297888 11 + 1.604 1.924 1.081
ENSG00000186480 E007 119.5085749 0.557408027 0.1131615331 0.304426946 7 155297889 155297959 71 + 1.887 2.250 1.215
ENSG00000186480 E008 11.3238447 0.005085815 0.0027227569 0.021698930 7 155297960 155298027 68 + 0.967 1.229 0.947
ENSG00000186480 E009 163.4774677 1.298456439 0.2630332516 0.502238542 7 155298259 155298366 108 + 2.016 2.389 1.248
ENSG00000186480 E010 198.1844931 1.369362734 0.2742969300 0.514260230 7 155298367 155298560 194 + 2.102 2.471 1.232
ENSG00000186480 E011 228.1344151 1.489243741 0.4064338540 0.633343883 7 155298561 155298697 137 + 2.248 2.470 0.739
ENSG00000186480 E012 189.5151009 0.084574882 0.0949339740 0.272851900 7 155301566 155301606 41 + 2.210 2.351 0.469
ENSG00000186480 E013 277.8430290 0.011658416 0.0111778023 0.063108744 7 155301607 155301690 84 + 2.400 2.490 0.300
ENSG00000186480 E014 435.5565780 0.002682973 0.5541389166 0.739207368 7 155302251 155302417 167 + 2.641 2.623 -0.060
ENSG00000186480 E015 6.7641123 0.004763494 0.8001219189 0.896400682 7 155302418 155302746 329 + 0.885 0.882 -0.012
ENSG00000186480 E016 411.5613778 0.004155521 0.8710053163 0.936499190 7 155302747 155302846 100 + 2.625 2.585 -0.131
ENSG00000186480 E017 3.2087347 0.279125564 0.7889717521 0.889865978 7 155302847 155303018 172 + 0.652 0.571 -0.357
ENSG00000186480 E018 43.4034084 0.001222063 0.4551271407 0.669588200 7 155303825 155303895 71 + 1.638 1.642 0.012
ENSG00000186480 E019 2250.4636064 0.037480067 0.0002286551 0.002986992 7 155308241 155310235 1995 + 3.421 3.209 -0.705