ENSG00000186470

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356386 ENSG00000186470 HEK293_OSMI2_6hA HEK293_TMG_6hB BTN3A2 protein_coding protein_coding 4.621469 3.452122 5.878305 0.3991621 0.2254896 0.7661959 0.5891626 0.4183349 0.5026567 0.2094458 0.25159666 0.259254 0.1289250 0.13700000 0.08890000 -0.04810000 0.9681659465 0.0001566828 FALSE TRUE
ENST00000377708 ENSG00000186470 HEK293_OSMI2_6hA HEK293_TMG_6hB BTN3A2 protein_coding protein_coding 4.621469 3.452122 5.878305 0.3991621 0.2254896 0.7661959 0.7108690 0.6232963 0.7073900 0.6232963 0.70739004 0.179877 0.1563458 0.14906667 0.11176667 -0.03730000 1.0000000000 0.0001566828 FALSE TRUE
ENST00000508906 ENSG00000186470 HEK293_OSMI2_6hA HEK293_TMG_6hB BTN3A2 protein_coding protein_coding 4.621469 3.452122 5.878305 0.3991621 0.2254896 0.7661959 1.8420318 1.5571503 2.5121770 0.2283162 0.50117184 0.686526 0.3974750 0.47036667 0.43390000 -0.03646667 0.9711609056 0.0001566828 FALSE TRUE
ENST00000528222 ENSG00000186470 HEK293_OSMI2_6hA HEK293_TMG_6hB BTN3A2 protein_coding retained_intron 4.621469 3.452122 5.878305 0.3991621 0.2254896 0.7661959 0.2849010 0.1711315 0.5495832 0.0890615 0.16158328 1.627315 0.0601625 0.05503333 0.09306667 0.03803333 0.8181468016 0.0001566828 FALSE FALSE
MSTRG.27797.7 ENSG00000186470 HEK293_OSMI2_6hA HEK293_TMG_6hB BTN3A2 protein_coding   4.621469 3.452122 5.878305 0.3991621 0.2254896 0.7661959 0.3577675 0.0255285 0.6472254 0.0255285 0.02245257 4.209339 0.0744125 0.00910000 0.11010000 0.10100000 0.0001566828 0.0001566828 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000186470 E001 0.0000000       6 26365159 26365169 11 +      
ENSG00000186470 E002 0.4820342 0.0213047819 0.17256677   6 26365170 26365197 28 + 0.246 0.000 -10.783
ENSG00000186470 E003 0.4820342 0.0213047819 0.17256677   6 26365198 26365199 2 + 0.246 0.000 -13.161
ENSG00000186470 E004 1.6266591 0.0118807471 0.19667478 0.42540059 6 26365200 26365203 4 + 0.482 0.260 -1.309
ENSG00000186470 E005 1.9307094 0.0144154337 0.09544154 0.27377154 6 26365204 26365207 4 + 0.549 0.260 -1.630
ENSG00000186470 E006 2.9267303 0.0801608585 0.08472637 0.25420310 6 26365208 26365217 10 + 0.682 0.350 -1.618
ENSG00000186470 E007 4.1870267 0.0121956567 0.01021347 0.05904421 6 26365218 26365227 10 + 0.819 0.422 -1.767
ENSG00000186470 E008 4.5621353 0.0168816557 0.05683668 0.19562972 6 26365228 26365230 3 + 0.819 0.540 -1.178
ENSG00000186470 E009 5.7339271 0.0079922558 0.01742799 0.08702874 6 26365231 26365257 27 + 0.909 0.588 -1.308
ENSG00000186470 E010 6.9754921 0.0042973242 0.06204394 0.20736683 6 26365258 26365265 8 + 0.961 0.741 -0.852
ENSG00000186470 E011 8.1964951 0.0037603626 0.01887181 0.09199077 6 26365266 26365268 3 + 1.038 0.772 -1.012
ENSG00000186470 E012 12.8416924 0.0140668967 0.03520270 0.14211206 6 26365269 26365352 84 + 1.198 0.984 -0.774
ENSG00000186470 E013 0.8096672 0.0306622121 0.36530747   6 26367975 26367989 15 + 0.305 0.149 -1.318
ENSG00000186470 E014 13.8756359 0.0026740835 0.15461494 0.36887571 6 26367990 26368050 61 + 1.197 1.082 -0.414
ENSG00000186470 E015 2.8044700 0.0114803547 0.88041486 0.94146901 6 26368051 26368177 127 + 0.550 0.587 0.171
ENSG00000186470 E016 4.0998417 0.1049016007 0.79694277 0.89453125 6 26368178 26368182 5 + 0.663 0.716 0.222
ENSG00000186470 E017 10.5875591 0.0469080201 0.61002882 0.77690313 6 26368183 26368267 85 + 1.069 1.007 -0.224
ENSG00000186470 E018 2.8074341 0.1394427249 0.77835396 0.88373763 6 26368268 26368449 182 + 0.586 0.538 -0.220
ENSG00000186470 E019 1.6583674 0.1359659348 0.62303687 0.78586705 6 26368450 26368564 115 + 0.358 0.485 0.681
ENSG00000186470 E020 11.0680436 0.0031028756 0.87655465 0.93945889 6 26368565 26368608 44 + 1.048 1.082 0.124
ENSG00000186470 E021 18.1236343 0.0018581596 0.74245725 0.86193604 6 26368609 26368720 112 + 1.244 1.289 0.159
ENSG00000186470 E022 21.6790772 0.0018306101 0.85342193 0.92684155 6 26368721 26368912 192 + 1.324 1.357 0.116
ENSG00000186470 E023 20.6609489 0.0075362912 0.61385219 0.77944676 6 26370322 26370424 103 + 1.296 1.359 0.220
ENSG00000186470 E024 19.7093707 0.0021857634 0.22368180 0.45784847 6 26370425 26370490 66 + 1.329 1.251 -0.273
ENSG00000186470 E025 12.2606782 0.0027210352 0.29023957 0.53085490 6 26370491 26370518 28 + 1.137 1.051 -0.309
ENSG00000186470 E026 16.9193081 0.0020261020 0.26694918 0.50654335 6 26370519 26370603 85 + 1.262 1.186 -0.268
ENSG00000186470 E027 0.3150090 0.0272368682 0.75286896   6 26372693 26372896 204 + 0.098 0.149 0.691
ENSG00000186470 E028 16.5703165 0.0019414533 0.29424424 0.53482147 6 26372897 26373097 201 + 1.183 1.289 0.374
ENSG00000186470 E029 0.3206185 0.0274424043 0.34359802   6 26373098 26373275 178 + 0.178 0.000 -12.607
ENSG00000186470 E030 12.8796357 0.0147951537 0.78368684 0.88678827 6 26373276 26373296 21 + 1.105 1.151 0.166
ENSG00000186470 E031 2.0094024 0.1071745159 0.73231630 0.85562907 6 26373297 26373386 90 + 0.482 0.425 -0.290
ENSG00000186470 E032 13.7519416 0.0047073526 0.88811665 0.94565018 6 26373387 26373413 27 + 1.145 1.150 0.017
ENSG00000186470 E033 3.2760931 0.0081195980 0.69568194 0.83270397 6 26373414 26374326 913 + 0.634 0.588 -0.204
ENSG00000186470 E034 21.2696971 0.0019706673 0.24282534 0.47974925 6 26374327 26374373 47 + 1.280 1.387 0.374
ENSG00000186470 E035 1.7378682 0.0144218094 0.50633588 0.70516219 6 26374374 26374770 397 + 0.357 0.485 0.689
ENSG00000186470 E036 19.1597571 0.0040644106 0.80895224 0.90155924 6 26374771 26374798 28 + 1.268 1.308 0.137
ENSG00000186470 E037 3.2384608 0.0082933229 0.82386464 0.91022737 6 26374799 26375514 716 + 0.608 0.588 -0.088
ENSG00000186470 E038 4.1532708 0.0062015334 0.37314638 0.60663837 6 26375515 26375796 282 + 0.746 0.631 -0.481
ENSG00000186470 E039 53.6165001 0.0008133514 0.42723891 0.64891328 6 26375797 26376528 732 + 1.697 1.754 0.193
ENSG00000186470 E040 184.9512016 0.0098868109 0.02185958 0.10210013 6 26376529 26378320 1792 + 2.209 2.322 0.377