ENSG00000186318

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313005 ENSG00000186318 HEK293_OSMI2_6hA HEK293_TMG_6hB BACE1 protein_coding protein_coding 13.18611 16.52133 9.975794 0.4139605 0.8327892 -0.7272535 4.4351714 5.016182 3.4318120 0.82121333 0.2177540 -0.5462946 0.32897083 0.3065333 0.34960000 0.04306667 9.030541e-01 2.676387e-13 FALSE TRUE
ENST00000392937 ENSG00000186318 HEK293_OSMI2_6hA HEK293_TMG_6hB BACE1 protein_coding protein_coding 13.18611 16.52133 9.975794 0.4139605 0.8327892 -0.7272535 0.8031882 0.000000 0.5448396 0.00000000 0.5448396 5.7939988 0.07777500 0.0000000 0.06486667 0.06486667 8.497527e-01 2.676387e-13 FALSE TRUE
ENST00000510630 ENSG00000186318 HEK293_OSMI2_6hA HEK293_TMG_6hB BACE1 protein_coding protein_coding 13.18611 16.52133 9.975794 0.4139605 0.8327892 -0.7272535 0.2536192 0.000000 0.6698838 0.00000000 0.6698838 6.0872162 0.01981667 0.0000000 0.05963333 0.05963333 8.152708e-01 2.676387e-13 FALSE TRUE
ENST00000528053 ENSG00000186318 HEK293_OSMI2_6hA HEK293_TMG_6hB BACE1 protein_coding protein_coding 13.18611 16.52133 9.975794 0.4139605 0.8327892 -0.7272535 1.1226145 1.842420 0.0000000 0.20783840 0.0000000 -7.5332677 0.08742083 0.1110333 0.00000000 -0.11103333 2.676387e-13 2.676387e-13 FALSE TRUE
ENST00000680681 ENSG00000186318 HEK293_OSMI2_6hA HEK293_TMG_6hB BACE1 protein_coding protein_coding 13.18611 16.52133 9.975794 0.4139605 0.8327892 -0.7272535 2.0795710 3.073752 2.7179384 0.25991185 0.5774874 -0.1768756 0.16255417 0.1855667 0.26913333 0.08356667 5.773161e-01 2.676387e-13 FALSE TRUE
ENST00000681753 ENSG00000186318 HEK293_OSMI2_6hA HEK293_TMG_6hB BACE1 protein_coding processed_transcript 13.18611 16.52133 9.975794 0.4139605 0.8327892 -0.7272535 2.3104469 4.007640 1.1940611 0.04238024 0.6944292 -1.7384397 0.16339583 0.2428333 0.10950000 -0.13333333 6.752276e-01 2.676387e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000186318 E001 1.4578306 0.011979283 0.20079748 0.43071909 11 117285232 117285697 466 - 0.168 0.442 1.904
ENSG00000186318 E002 0.3032425 0.024441170 0.63083427   11 117285698 117285705 8 - 0.000 0.159 11.198
ENSG00000186318 E003 174.1135615 0.125973467 0.28123104 0.52151147 11 117285706 117287350 1645 - 2.255 2.189 -0.221
ENSG00000186318 E004 14.0072512 0.116254185 0.02558051 0.11400794 11 117287351 117287411 61 - 1.334 1.020 -1.116
ENSG00000186318 E005 384.3202399 0.015749335 0.32777726 0.56683283 11 117287412 117289012 1601 - 2.528 2.564 0.120
ENSG00000186318 E006 128.5134641 0.569769431 0.38355183 0.61520371 11 117289013 117289270 258 - 1.988 2.117 0.432
ENSG00000186318 E007 127.6520663 0.504343455 0.25520559 0.49380570 11 117289271 117289486 216 - 1.917 2.134 0.728
ENSG00000186318 E008 61.3307722 0.229231599 0.18084284 0.40506249 11 117289487 117289534 48 - 1.594 1.823 0.774
ENSG00000186318 E009 132.6638486 0.517945373 0.25534673 0.49398773 11 117289535 117289807 273 - 1.933 2.151 0.730
ENSG00000186318 E010 1.2974104 0.013696863 0.62631949   11 117289808 117290459 652 - 0.383 0.323 -0.357
ENSG00000186318 E011 0.4646582 0.021768165 0.90810720   11 117290460 117290487 28 - 0.168 0.159 -0.098
ENSG00000186318 E012 49.2537160 0.189844769 0.27161711 0.51148034 11 117290488 117290502 15 - 1.549 1.716 0.569
ENSG00000186318 E013 115.8490737 0.531660613 0.37808096 0.61058138 11 117290503 117290633 131 - 1.941 2.073 0.440
ENSG00000186318 E014 67.7975464 0.358966046 0.40410012 0.63161982 11 117290634 117290659 26 - 1.730 1.837 0.362
ENSG00000186318 E015 0.0000000       11 117290660 117290899 240 -      
ENSG00000186318 E016 107.2260800 0.505556479 0.38252735 0.61426247 11 117290900 117291049 150 - 1.913 2.037 0.416
ENSG00000186318 E017 0.1614157 0.031917908 0.19140301   11 117291050 117291711 662 - 0.168 0.000 -12.428
ENSG00000186318 E018 80.8684653 0.265841938 0.46376177 0.67568711 11 117291712 117291813 102 - 1.834 1.902 0.227
ENSG00000186318 E019 1.6799975 1.264552206 0.68388551 0.82521184 11 117291814 117292958 1145 - 0.662 0.210 -2.533
ENSG00000186318 E020 0.1723744 0.035935507 1.00000000   11 117292959 117293016 58 - 0.000 0.087 10.200
ENSG00000186318 E021 0.1723744 0.035935507 1.00000000   11 117293017 117293053 37 - 0.000 0.087 10.200
ENSG00000186318 E022 89.5855970 0.501738812 0.53559147 0.72601392 11 117293054 117293188 135 - 1.904 1.935 0.105
ENSG00000186318 E023 8.9647083 0.004723023 0.54059348 0.72942901 11 117293189 117293870 682 - 0.881 1.002 0.456
ENSG00000186318 E024 62.1470007 0.000747038 0.00382810 0.02818310 11 117293871 117293933 63 - 1.829 1.744 -0.286
ENSG00000186318 E025 56.4274919 0.002201474 0.29136111 0.53195608 11 117293934 117294008 75 - 1.731 1.730 -0.003
ENSG00000186318 E026 3.9597934 0.014053207 0.10115405 0.28388228 11 117294009 117294441 433 - 0.792 0.588 -0.852
ENSG00000186318 E027 82.9403110 0.018513278 0.19477091 0.42304450 11 117295131 117295262 132 - 1.903 1.888 -0.049
ENSG00000186318 E028 56.2173869 0.021675559 0.18981433 0.41673831 11 117295263 117295318 56 - 1.745 1.718 -0.093
ENSG00000186318 E029 45.6609319 0.019801721 0.36458675 0.59954587 11 117295319 117295347 29 - 1.633 1.636 0.010
ENSG00000186318 E030 0.4756169 0.024049057 0.36332703   11 117295430 117295485 56 - 0.000 0.221 11.784
ENSG00000186318 E031 0.8810853 0.017267182 0.14069055   11 117295498 117295636 139 - 0.000 0.323 12.524
ENSG00000186318 E032 51.5279705 0.058260298 0.42347787 0.64623493 11 117296873 117296961 89 - 1.688 1.688 0.000
ENSG00000186318 E033 2.3199130 0.184694020 0.23807725 0.47440852 11 117299648 117299696 49 - 0.628 0.415 -1.019
ENSG00000186318 E034 4.0276905 0.027536117 0.01560487 0.08038053 11 117300671 117300737 67 - 0.288 0.783 2.428
ENSG00000186318 E035 98.5493749 0.064398693 0.96716299 0.98552446 11 117315535 117316259 725 - 1.895 1.995 0.336