ENSG00000186298

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335007 ENSG00000186298 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP1CC protein_coding protein_coding 138.4704 48.76337 225.7314 12.46257 8.550812 2.210505 98.777247 40.075279 160.873199 11.8382270 5.671322 2.004869 0.75061250 0.794500000 0.7128333 -0.08166667 6.219814e-01 3.441123e-05 FALSE TRUE
ENST00000340766 ENSG00000186298 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP1CC protein_coding protein_coding 138.4704 48.76337 225.7314 12.46257 8.550812 2.210505 7.590981 3.474381 9.656862 0.4407654 1.093016 1.472145 0.05584167 0.079133333 0.0426000 -0.03653333 2.749003e-01 3.441123e-05 FALSE TRUE
MSTRG.8013.12 ENSG00000186298 HEK293_OSMI2_6hA HEK293_TMG_6hB PPP1CC protein_coding   138.4704 48.76337 225.7314 12.46257 8.550812 2.210505 19.780768 0.116866 36.866231 0.1168660 2.070013 8.183242 0.09116667 0.001866667 0.1632000 0.16133333 3.441123e-05 3.441123e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000186298 E001 11.875134 4.068231e-01 1.144508e-01 3.065514e-01 12 110708803 110708962 160 - 0.921 1.299 1.364
ENSG00000186298 E002 8.555814 3.337801e-01 1.347117e-01 3.392473e-01 12 110708963 110709034 72 - 0.817 1.139 1.200
ENSG00000186298 E003 6.096161 7.325062e-02 2.133923e-01 4.456938e-01 12 110715002 110715147 146 - 0.732 0.947 0.839
ENSG00000186298 E004 221.849465 2.772358e-04 9.968529e-06 2.091273e-04 12 110719680 110719907 228 - 2.236 2.369 0.444
ENSG00000186298 E005 513.655012 2.284268e-04 3.916464e-08 1.602407e-06 12 110719908 110719982 75 - 2.603 2.718 0.381
ENSG00000186298 E006 1232.192550 6.248508e-03 3.175937e-02 1.325112e-01 12 110719983 110720204 222 - 2.985 3.089 0.346
ENSG00000186298 E007 886.429786 4.219104e-03 1.546349e-02 7.983147e-02 12 110720205 110720365 161 - 2.843 2.942 0.329
ENSG00000186298 E008 1616.557240 3.881543e-04 1.760653e-01 3.985542e-01 12 110720366 110720729 364 - 3.122 3.150 0.093
ENSG00000186298 E009 520.269573 4.134835e-04 5.014899e-01 7.018852e-01 12 110720730 110720747 18 - 2.638 2.634 -0.016
ENSG00000186298 E010 974.276819 6.459875e-04 4.976805e-01 6.992554e-01 12 110720748 110720920 173 - 2.904 2.925 0.069
ENSG00000186298 E011 1067.028618 2.381649e-04 3.750768e-02 1.483284e-01 12 110720921 110721104 184 - 2.941 2.980 0.131
ENSG00000186298 E012 728.494995 1.308745e-04 4.134124e-02 1.582093e-01 12 110721105 110721165 61 - 2.774 2.816 0.143
ENSG00000186298 E013 15.034501 4.390716e-02 9.554931e-01 9.796227e-01 12 110721301 110721769 469 - 1.134 1.119 -0.057
ENSG00000186298 E014 24.950500 1.980657e-03 2.068779e-01 4.380080e-01 12 110721770 110722134 365 - 1.308 1.418 0.379
ENSG00000186298 E015 1036.831402 9.763965e-05 3.109431e-01 5.513647e-01 12 110722135 110722269 135 - 2.937 2.933 -0.012
ENSG00000186298 E016 35.895739 1.215228e-01 8.153018e-01 9.053738e-01 12 110722270 110722471 202 - 1.499 1.446 -0.183
ENSG00000186298 E017 1018.139964 1.021672e-04 1.912974e-06 5.018800e-05 12 110722472 110722623 152 - 2.940 2.883 -0.188
ENSG00000186298 E018 742.926391 9.893307e-05 7.060929e-06 1.549235e-04 12 110722624 110722695 72 - 2.804 2.741 -0.209
ENSG00000186298 E019 895.532696 9.250737e-05 9.249776e-07 2.652524e-05 12 110724660 110724764 105 - 2.885 2.823 -0.208
ENSG00000186298 E020 6.646431 2.634614e-01 5.374425e-01 7.272634e-01 12 110724765 110726679 1915 - 0.762 0.957 0.755
ENSG00000186298 E021 1.721818 1.219891e-02 2.637966e-01 5.030569e-01 12 110730525 110730528 4 - 0.431 0.208 -1.467
ENSG00000186298 E022 881.594652 9.849276e-05 2.200361e-07 7.501945e-06 12 110730529 110730650 122 - 2.880 2.812 -0.225
ENSG00000186298 E023 943.175118 2.097413e-03 5.427954e-03 3.684660e-02 12 110730651 110730759 109 - 2.909 2.837 -0.241
ENSG00000186298 E024 672.221053 4.564639e-03 3.977564e-02 1.541529e-01 12 110731770 110731815 46 - 2.764 2.686 -0.259
ENSG00000186298 E025 683.294464 5.421381e-03 3.022428e-01 5.428379e-01 12 110731816 110731901 86 - 2.764 2.720 -0.147
ENSG00000186298 E026 3.172634 8.330504e-03 7.559707e-02 2.360166e-01 12 110731902 110732983 1082 - 0.482 0.772 1.272
ENSG00000186298 E027 2.777029 8.741270e-02 7.626128e-01 8.741462e-01 12 110734718 110734986 269 - 0.508 0.601 0.429
ENSG00000186298 E028 1.374596 1.316344e-02 9.948700e-01   12 110735940 110736021 82 - 0.340 0.348 0.049
ENSG00000186298 E029 437.153706 6.187990e-04 6.108816e-01 7.775344e-01 12 110742653 110742939 287 - 2.558 2.579 0.069