ENSG00000186111

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335312 ENSG00000186111 HEK293_OSMI2_6hA HEK293_TMG_6hB PIP5K1C protein_coding protein_coding 14.25182 22.40917 7.991095 2.972095 0.2863569 -1.486464 12.018155 19.212765 6.080665 2.7373809 0.25898082 -1.6581442 0.8275667 0.8548 0.7605667 -0.09423333 0.05981800 0.04367221 FALSE TRUE
MSTRG.16169.5 ENSG00000186111 HEK293_OSMI2_6hA HEK293_TMG_6hB PIP5K1C protein_coding   14.25182 22.40917 7.991095 2.972095 0.2863569 -1.486464 1.464495 2.255768 1.458016 0.3411666 0.07859007 -0.6261329 0.1140708 0.1001 0.1835667 0.08346667 0.04367221 0.04367221 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000186111 E001 428.9210354 1.1854487822 0.373791296 0.60717480 19 3630183 3631109 927 - 2.314 2.626 1.041
ENSG00000186111 E002 84.5458717 0.1715438237 0.018832568 0.09188127 19 3631110 3631135 26 - 1.451 1.948 1.686
ENSG00000186111 E003 451.0722928 1.1652355119 0.321657183 0.56117596 19 3631136 3631967 832 - 2.296 2.654 1.196
ENSG00000186111 E004 423.9796702 1.2386173510 0.453363687 0.66825107 19 3631968 3632875 908 - 2.372 2.611 0.796
ENSG00000186111 E005 112.7459107 0.4693490986 0.301510509 0.54201293 19 3632876 3633169 294 - 1.798 2.039 0.813
ENSG00000186111 E006 17.3333795 0.0221350444 0.436845177 0.65633990 19 3633437 3633520 84 - 1.063 1.244 0.645
ENSG00000186111 E007 19.6582406 0.2003608632 0.741771495 0.86152088 19 3636601 3637535 935 - 1.174 1.280 0.376
ENSG00000186111 E008 1.4891860 0.0126307382 0.116649892 0.31024611 19 3637536 3637613 78 - 0.510 0.286 -1.263
ENSG00000186111 E009 4.8928956 0.1539246118 0.941856232 0.97318213 19 3637614 3638006 393 - 0.636 0.735 0.416
ENSG00000186111 E010 60.4479429 0.0006909613 0.013195667 0.07122649 19 3638884 3639016 133 - 1.751 1.727 -0.080
ENSG00000186111 E011 76.2818301 0.0012507560 0.030426306 0.12862715 19 3641705 3641809 105 - 1.826 1.825 -0.003
ENSG00000186111 E012 45.9745682 0.0021605541 0.563693076 0.74588248 19 3642907 3642939 33 - 1.559 1.626 0.228
ENSG00000186111 E013 46.1551348 0.0010595280 0.458165663 0.67183362 19 3643243 3643248 6 - 1.566 1.624 0.199
ENSG00000186111 E014 109.2669975 0.0005578298 0.462342844 0.67477182 19 3643249 3643381 133 - 1.923 2.000 0.258
ENSG00000186111 E015 43.7027886 0.0148741227 0.572164078 0.75179283 19 3644087 3644088 2 - 1.544 1.603 0.200
ENSG00000186111 E016 115.6863767 0.0104507374 0.047701075 0.17429961 19 3644089 3644251 163 - 2.009 2.002 -0.023
ENSG00000186111 E017 84.3728848 0.0319560974 0.020855804 0.09887207 19 3645974 3646058 85 - 1.940 1.841 -0.333
ENSG00000186111 E018 67.3397401 0.0282848305 0.003993688 0.02911941 19 3647338 3647386 49 - 1.877 1.729 -0.500
ENSG00000186111 E019 53.5827243 0.0154542502 0.203296628 0.43368057 19 3648625 3648708 84 - 1.665 1.675 0.037
ENSG00000186111 E020 0.0000000       19 3649355 3649429 75 -      
ENSG00000186111 E021 0.0000000       19 3649891 3650023 133 -      
ENSG00000186111 E022 95.1619271 0.0417739740 0.163749734 0.38227140 19 3651826 3652031 206 - 1.934 1.913 -0.069
ENSG00000186111 E023 164.0094719 0.0284506218 0.019794649 0.09519130 19 3653290 3653589 300 - 2.206 2.134 -0.240
ENSG00000186111 E024 119.2014133 0.0162170105 0.001401814 0.01291560 19 3656405 3656557 153 - 2.091 1.988 -0.344
ENSG00000186111 E025 111.4078552 0.0316252985 0.011449985 0.06421706 19 3660966 3661083 118 - 2.065 1.958 -0.361
ENSG00000186111 E026 0.6731895 0.0702690544 0.024913125   19 3661373 3661526 154 - 0.429 0.074 -3.176
ENSG00000186111 E027 82.5060275 0.0347561748 0.011146480 0.06299054 19 3661871 3661929 59 - 1.948 1.825 -0.417
ENSG00000186111 E028 83.4368081 0.0204204851 0.006098016 0.04020278 19 3661930 3662001 72 - 1.935 1.838 -0.325
ENSG00000186111 E029 65.2385898 0.0215228070 0.027079877 0.11853509 19 3664822 3664856 35 - 1.807 1.744 -0.212
ENSG00000186111 E030 62.2889079 0.0062875223 0.117838671 0.31227809 19 3664857 3664914 58 - 1.733 1.747 0.046
ENSG00000186111 E031 41.9370507 0.0206660242 0.585616527 0.76069840 19 3667322 3667353 32 - 1.518 1.589 0.242
ENSG00000186111 E032 0.3336024 0.0244411696 1.000000000   19 3668404 3668440 37 - 0.000 0.137 8.731
ENSG00000186111 E033 1.8316517 0.9622681569 0.896917131 0.95025989 19 3669673 3669904 232 - 0.443 0.386 -0.312
ENSG00000186111 E034 42.5394064 0.0105661150 0.949151619 0.97667966 19 3700297 3700488 192 - 1.494 1.607 0.386