ENSG00000186020

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334116 ENSG00000186020 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF529 protein_coding protein_coding 6.972943 2.873217 12.58274 0.1689272 0.2531303 2.126841 0.4431214 0.13197291 0.5375378 0.13197291 0.1181492 1.9473430 0.08251250 0.05203333 0.04313333 -0.00890000 0.795156687 0.004672079 FALSE TRUE
ENST00000586115 ENSG00000186020 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF529 protein_coding protein_coding 6.972943 2.873217 12.58274 0.1689272 0.2531303 2.126841 0.1063842 0.18288959 0.0000000 0.18288959 0.0000000 -4.2697034 0.02555417 0.05990000 0.00000000 -0.05990000 0.719228566 0.004672079   FALSE
ENST00000586458 ENSG00000186020 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF529 protein_coding processed_transcript 6.972943 2.873217 12.58274 0.1689272 0.2531303 2.126841 0.8708814 0.66055143 1.0837315 0.02644726 0.1235591 0.7058387 0.17385833 0.23103333 0.08650000 -0.14453333 0.004672079 0.004672079   FALSE
ENST00000591340 ENSG00000186020 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF529 protein_coding protein_coding 6.972943 2.873217 12.58274 0.1689272 0.2531303 2.126841 2.0956696 1.16349371 3.8548996 0.18327789 0.1948140 1.7196208 0.31876250 0.40066667 0.30610000 -0.09456667 0.562182472 0.004672079 FALSE TRUE
MSTRG.17032.12 ENSG00000186020 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF529 protein_coding   6.972943 2.873217 12.58274 0.1689272 0.2531303 2.126841 0.1615311 0.31686834 0.0000000 0.17912467 0.0000000 -5.0306378 0.03207083 0.10430000 0.00000000 -0.10430000 0.116530736 0.004672079   FALSE
MSTRG.17032.15 ENSG00000186020 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF529 protein_coding   6.972943 2.873217 12.58274 0.1689272 0.2531303 2.126841 0.8410319 0.12777462 2.2029454 0.06838713 0.5258561 4.0055858 0.09412083 0.04720000 0.17356667 0.12636667 0.257901663 0.004672079   FALSE
MSTRG.17032.8 ENSG00000186020 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF529 protein_coding   6.972943 2.873217 12.58274 0.1689272 0.2531303 2.126841 0.9285752 0.09425412 3.3720441 0.09425412 0.1045052 5.0197191 0.08925417 0.03716667 0.26843333 0.23126667 0.114966256 0.004672079 FALSE TRUE
MSTRG.17032.9 ENSG00000186020 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF529 protein_coding   6.972943 2.873217 12.58274 0.1689272 0.2531303 2.126841 0.5859884 0.09935518 0.8963793 0.06838946 0.1611877 3.0510934 0.06357500 0.03273333 0.07183333 0.03910000 0.660253959 0.004672079 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000186020 E001 0.0000000       19 36534774 36534882 109 -      
ENSG00000186020 E002 0.1614157 0.0324741535 1.000000e+00   19 36534883 36534961 79 - 0.066 0.001 -6.459
ENSG00000186020 E003 0.0000000       19 36543613 36543615 3 -      
ENSG00000186020 E004 1.3391769 0.0128743873 9.175273e-01   19 36543616 36543828 213 - 0.298 0.355 0.357
ENSG00000186020 E005 136.3639195 0.0141579405 1.884669e-03 0.0162948387 19 36543829 36545869 2041 - 1.984 2.229 0.819
ENSG00000186020 E006 18.7701658 0.0018362235 1.681204e-01 0.3880913263 19 36545870 36545933 64 - 1.221 1.155 -0.237
ENSG00000186020 E007 43.9322106 0.0097275490 9.134227e-02 0.2661499666 19 36545934 36546636 703 - 1.515 1.705 0.645
ENSG00000186020 E008 13.9140564 0.0026318373 1.548971e-02 0.0799146186 19 36546637 36546724 88 - 1.002 1.301 1.069
ENSG00000186020 E009 22.7604347 0.0016611383 3.143646e-01 0.5545594740 19 36546725 36546824 100 - 1.250 1.399 0.517
ENSG00000186020 E010 88.5875489 0.0005961477 1.143481e-01 0.3063937689 19 36546825 36547389 565 - 1.863 1.864 0.003
ENSG00000186020 E011 46.3271054 0.0010726887 8.421191e-02 0.2531892957 19 36547390 36547557 168 - 1.599 1.561 -0.130
ENSG00000186020 E012 85.7928881 0.0030751569 3.907865e-04 0.0046421752 19 36547558 36548012 455 - 1.875 1.762 -0.382
ENSG00000186020 E013 41.3304390 0.0008727672 5.047845e-04 0.0057233285 19 36548013 36548100 88 - 1.571 1.398 -0.592
ENSG00000186020 E014 44.0621371 0.0032845182 2.342999e-02 0.1073187967 19 36548101 36548226 126 - 1.584 1.496 -0.300
ENSG00000186020 E015 17.9097686 0.0027906569 9.061991e-03 0.0541002087 19 36548227 36548227 1 - 1.230 1.020 -0.752
ENSG00000186020 E016 30.2303608 0.0012861124 3.262985e-02 0.1350515186 19 36548228 36548322 95 - 1.426 1.327 -0.345
ENSG00000186020 E017 10.6012965 0.0145793749 3.724885e-01 0.6060835464 19 36549235 36549357 123 - 0.988 0.937 -0.190
ENSG00000186020 E018 8.5739046 0.0193253913 1.672458e-01 0.3868963297 19 36551810 36551876 67 - 0.926 0.782 -0.557
ENSG00000186020 E019 12.0945846 0.0081680091 1.297393e-01 0.3314225708 19 36551877 36551977 101 - 1.057 0.933 -0.457
ENSG00000186020 E020 38.7814641 0.0110226286 4.164229e-02 0.1589950942 19 36554670 36554796 127 - 1.527 1.423 -0.356
ENSG00000186020 E021 29.2955181 0.0016481811 6.122376e-05 0.0009901662 19 36556104 36556197 94 - 1.437 1.155 -0.989
ENSG00000186020 E022 9.9157911 0.0092150184 6.719199e-01 0.8175291611 19 36572333 36572392 60 - 0.933 1.046 0.421
ENSG00000186020 E023 6.4747157 0.2331227554 1.437875e-01 0.3530562319 19 36573140 36573292 153 - 0.697 1.054 1.376
ENSG00000186020 E024 42.8390461 0.2790236422 2.114117e-02 0.0997986729 19 36580255 36582397 2143 - 1.362 1.927 1.923
ENSG00000186020 E025 8.2923038 0.0037131114 3.348891e-01 0.5734532599 19 36582398 36582704 307 - 0.841 1.021 0.679
ENSG00000186020 E026 2.7762894 0.0223452939 5.694894e-01 0.7498770642 19 36587402 36587457 56 - 0.520 0.462 -0.286
ENSG00000186020 E027 16.4849282 0.0025770182 4.768247e-01 0.6848807865 19 36589615 36589701 87 - 1.125 1.257 0.470
ENSG00000186020 E028 9.6197374 0.5378893593 4.776968e-01 0.6855722406 19 36605126 36605283 158 - 0.892 1.110 0.806