ENSG00000186017

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000424129 ENSG00000186017 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF566 protein_coding protein_coding 2.141551 0.670099 4.271417 0.1443877 0.09218318 2.654272 0.01867368 0.07813609 0.00000000 0.03606927 0.00000000 -3.1397330 0.01807500 0.11380000 0.00000000 -0.11380000 0.00133239 0.00133239 FALSE TRUE
ENST00000434377 ENSG00000186017 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF566 protein_coding protein_coding 2.141551 0.670099 4.271417 0.1443877 0.09218318 2.654272 1.50854250 0.38055457 3.04779347 0.05862875 0.19454235 2.9688949 0.69257083 0.59686667 0.71316667 0.11630000 0.75653659 0.00133239 FALSE TRUE
ENST00000452939 ENSG00000186017 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF566 protein_coding protein_coding 2.141551 0.670099 4.271417 0.1443877 0.09218318 2.654272 0.01700451 0.02642103 0.00000000 0.02642103 0.00000000 -1.8647717 0.03943333 0.05726667 0.00000000 -0.05726667 0.57242912 0.00133239 FALSE TRUE
ENST00000587567 ENSG00000186017 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF566 protein_coding protein_coding 2.141551 0.670099 4.271417 0.1443877 0.09218318 2.654272 0.10911503 0.13453304 0.08760939 0.13453304 0.08760939 -0.5663074 0.07951250 0.14200000 0.02133333 -0.12066667 0.85017609 0.00133239 FALSE TRUE
MSTRG.17027.11 ENSG00000186017 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF566 protein_coding   2.141551 0.670099 4.271417 0.1443877 0.09218318 2.654272 0.08141843 0.00000000 0.45448161 0.00000000 0.06381965 5.5375496 0.02034167 0.00000000 0.10586667 0.10586667 0.05135948 0.00133239 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000186017 E001 21.8093081 0.0218498759 0.002248018 0.01871765 19 36445119 36445624 506 - 1.150 1.467 1.110
ENSG00000186017 E002 10.5716276 0.0097468374 0.173717511 0.39548534 19 36445625 36445791 167 - 0.902 1.074 0.640
ENSG00000186017 E003 13.7887886 0.0026351413 0.020256126 0.09677209 19 36445792 36446060 269 - 0.988 1.237 0.896
ENSG00000186017 E004 5.8946939 0.0054191050 0.821307977 0.90876671 19 36446061 36446115 55 - 0.713 0.751 0.156
ENSG00000186017 E005 133.2128546 0.0007054239 0.488458783 0.69297842 19 36446116 36449230 3115 - 1.979 2.004 0.084
ENSG00000186017 E006 28.3021934 0.0067249612 0.193887482 0.42200546 19 36449231 36449398 168 - 1.344 1.217 -0.445
ENSG00000186017 E007 32.3555797 0.0011096136 0.086431004 0.25728260 19 36449399 36449555 157 - 1.403 1.256 -0.513
ENSG00000186017 E008 44.9861008 0.0011823097 0.071811042 0.22842096 19 36449556 36450001 446 - 1.541 1.411 -0.445
ENSG00000186017 E009 0.0000000       19 36456460 36456549 90 -      
ENSG00000186017 E010 12.5167795 0.0178031458 0.250654087 0.48868410 19 36472911 36472990 80 - 1.019 0.855 -0.618
ENSG00000186017 E011 10.9822427 0.0784545347 0.441506386 0.65975276 19 36472991 36473006 16 - 0.968 0.846 -0.463
ENSG00000186017 E012 1.3188523 0.5272478600 0.955422979   19 36473007 36473009 3 - 0.291 0.251 -0.287
ENSG00000186017 E013 0.6246688 0.0192576323 0.654513972   19 36473010 36473140 131 - 0.187 0.000 -10.120
ENSG00000186017 E014 0.8026527 0.0172640567 0.483152622   19 36473141 36473331 191 - 0.223 0.000 -10.418
ENSG00000186017 E015 18.9710863 0.0415116302 0.406758025 0.63357870 19 36473332 36473458 127 - 1.182 1.067 -0.411
ENSG00000186017 E016 0.3559677 0.4494348507 1.000000000   19 36476109 36476548 440 - 0.106 0.000 -8.169
ENSG00000186017 E017 11.9684212 0.0028169164 0.674278656 0.81907670 19 36476549 36476616 68 - 0.994 0.941 -0.196
ENSG00000186017 E018 0.1614157 0.0327188600 1.000000000   19 36489413 36489435 23 - 0.055 0.000 -8.162
ENSG00000186017 E019 4.4861037 0.0055903572 0.525466449 0.71880768 19 36489474 36489485 12 - 0.639 0.522 -0.531
ENSG00000186017 E020 13.6217131 0.0034865429 0.317164992 0.55716344 19 36489486 36490988 1503 - 1.012 1.127 0.420