ENSG00000185697

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000522677 ENSG00000185697 HEK293_OSMI2_6hA HEK293_TMG_6hB MYBL1 protein_coding protein_coding 3.458657 1.580844 5.989239 0.1298014 0.4463271 1.914987 2.3143634 1.0907826 3.58783401 0.11340345 0.73963759 1.708599 0.7008000 0.6885000 0.5868333 -0.1016667 7.996202e-01 1.132853e-05 FALSE TRUE
ENST00000523304 ENSG00000185697 HEK293_OSMI2_6hA HEK293_TMG_6hB MYBL1 protein_coding retained_intron 3.458657 1.580844 5.989239 0.1298014 0.4463271 1.914987 0.1530389 0.2670238 0.09751445 0.00374224 0.01119508 -1.365479 0.0839125 0.1715667 0.0166000 -0.1549667 1.132853e-05 1.132853e-05 FALSE FALSE
ENST00000524176 ENSG00000185697 HEK293_OSMI2_6hA HEK293_TMG_6hB MYBL1 protein_coding protein_coding 3.458657 1.580844 5.989239 0.1298014 0.4463271 1.914987 0.7497032 0.1182720 1.89753317 0.06266900 0.51380660 3.894430 0.1535750 0.0749000 0.3335667 0.2586667 3.131417e-01 1.132853e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000185697 E001 84.177995 1.219709273 3.680221e-01 6.024253e-01 8 66562175 66563205 1031 - 1.748 2.080 1.117
ENSG00000185697 E002 21.785095 0.519798468 2.297697e-01 4.648912e-01 8 66563206 66563264 59 - 1.178 1.511 1.161
ENSG00000185697 E003 86.918654 1.230077958 3.433221e-01 5.809999e-01 8 66563265 66564671 1407 - 1.753 2.108 1.191
ENSG00000185697 E004 10.861937 0.424842984 4.143384e-01 6.393084e-01 8 66564672 66564696 25 - 0.936 1.155 0.801
ENSG00000185697 E005 9.128988 0.497839761 6.073049e-01 7.750907e-01 8 66564697 66564700 4 - 0.887 1.042 0.579
ENSG00000185697 E006 27.533089 0.635146063 4.069669e-01 6.336977e-01 8 66564701 66564825 125 - 1.314 1.529 0.743
ENSG00000185697 E007 1.119875 0.014641777 5.113543e-01   8 66565133 66565507 375 - 0.296 0.215 -0.613
ENSG00000185697 E008 11.015929 0.003667449 1.210964e-01 3.176103e-01 8 66566064 66566243 180 - 1.025 0.937 -0.326
ENSG00000185697 E009 29.490878 0.001591905 9.042556e-02 2.645364e-01 8 66566684 66566788 105 - 1.405 1.380 -0.087
ENSG00000185697 E010 29.987932 0.023082952 1.787320e-01 4.022796e-01 8 66566876 66566992 117 - 1.409 1.383 -0.090
ENSG00000185697 E011 22.895126 0.001793082 1.236503e-02 6.789091e-02 8 66572482 66572596 115 - 1.316 1.196 -0.424
ENSG00000185697 E012 28.178651 0.010505148 4.702824e-03 3.301970e-02 8 66573364 66573506 143 - 1.406 1.246 -0.558
ENSG00000185697 E013 27.627046 0.021659127 1.414760e-02 7.494503e-02 8 66576007 66576133 127 - 1.397 1.245 -0.530
ENSG00000185697 E014 39.089860 0.035388273 1.637092e-01 3.822353e-01 8 66576134 66576375 242 - 1.523 1.482 -0.141
ENSG00000185697 E015 38.836009 0.040587420 1.953262e-01 4.237519e-01 8 66580133 66580366 234 - 1.519 1.487 -0.109
ENSG00000185697 E016 24.031789 0.031899569 4.158227e-02 1.588437e-01 8 66592440 66592544 105 - 1.337 1.209 -0.451
ENSG00000185697 E017 20.929733 0.050636263 2.733685e-03 2.176579e-02 8 66593120 66593194 75 - 1.305 0.967 -1.215
ENSG00000185697 E018 35.927722 0.030973046 2.177642e-01 4.507450e-01 8 66595583 66595757 175 - 1.483 1.475 -0.029
ENSG00000185697 E019 39.452061 0.014113492 4.317325e-02 1.630016e-01 8 66597330 66597509 180 - 1.534 1.478 -0.191
ENSG00000185697 E020 21.258192 0.013704348 1.608206e-01 3.779969e-01 8 66597510 66597524 15 - 1.273 1.242 -0.107
ENSG00000185697 E021 22.508250 0.002431662 3.004546e-01 5.409106e-01 8 66597525 66597550 26 - 1.288 1.304 0.057
ENSG00000185697 E022 32.436015 0.016105498 2.035842e-01 4.340329e-01 8 66599050 66599142 93 - 1.441 1.440 -0.004
ENSG00000185697 E023 28.918764 0.018159215 4.635882e-01 6.755355e-01 8 66601698 66601769 72 - 1.382 1.422 0.141
ENSG00000185697 E024 36.271396 0.037018666 1.142505e-01 3.062338e-01 8 66602418 66602523 106 - 1.497 1.444 -0.180
ENSG00000185697 E025 5.072500 0.005952189 8.007038e-07 2.341218e-05 8 66612145 66612513 369 - 0.420 1.159 3.042
ENSG00000185697 E026 6.553431 0.005920884 2.984912e-08 1.256274e-06 8 66612514 66612818 305 - 0.494 1.262 3.028
ENSG00000185697 E027 42.562835 0.041180115 1.433695e-01 3.525066e-01 8 66612819 66614247 1429 - 1.477 1.758 0.956