ENSG00000185684

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392352 ENSG00000185684 HEK293_OSMI2_6hA HEK293_TMG_6hB EP400P1 transcribed_unprocessed_pseudogene processed_transcript 10.01058 11.84309 7.655863 0.1942362 0.2979247 -0.6287432 1.1881888 1.5722840 0.6968372 0.22101569 0.1986567 -1.1625587 0.11711250 0.13230000 0.09080000 -0.04150000 0.6902190625 0.0005646918 FALSE TRUE
ENST00000407361 ENSG00000185684 HEK293_OSMI2_6hA HEK293_TMG_6hB EP400P1 transcribed_unprocessed_pseudogene processed_transcript 10.01058 11.84309 7.655863 0.1942362 0.2979247 -0.6287432 0.2425883 0.6860191 0.0000000 0.22323648 0.0000000 -6.1210550 0.02082083 0.05746667 0.00000000 -0.05746667 0.0005646918 0.0005646918 FALSE TRUE
ENST00000537558 ENSG00000185684 HEK293_OSMI2_6hA HEK293_TMG_6hB EP400P1 transcribed_unprocessed_pseudogene processed_transcript 10.01058 11.84309 7.655863 0.1942362 0.2979247 -0.6287432 0.8929484 0.4863624 1.2327180 0.28427305 0.4945328 1.3240333 0.09797500 0.04073333 0.15670000 0.11596667 0.5068391606 0.0005646918   FALSE
ENST00000613241 ENSG00000185684 HEK293_OSMI2_6hA HEK293_TMG_6hB EP400P1 transcribed_unprocessed_pseudogene processed_transcript 10.01058 11.84309 7.655863 0.1942362 0.2979247 -0.6287432 0.5596137 0.5084543 0.5786249 0.04570945 0.3186284 0.1831316 0.05376667 0.04306667 0.07896667 0.03590000 1.0000000000 0.0005646918   FALSE
ENST00000690966 ENSG00000185684 HEK293_OSMI2_6hA HEK293_TMG_6hB EP400P1 transcribed_unprocessed_pseudogene processed_transcript 10.01058 11.84309 7.655863 0.1942362 0.2979247 -0.6287432 1.1314210 2.2444434 0.2141132 0.30487920 0.2141132 -3.3304715 0.10279583 0.18890000 0.02640000 -0.16250000 0.1455658209 0.0005646918 FALSE TRUE
MSTRG.8334.15 ENSG00000185684 HEK293_OSMI2_6hA HEK293_TMG_6hB EP400P1 transcribed_unprocessed_pseudogene   10.01058 11.84309 7.655863 0.1942362 0.2979247 -0.6287432 0.8288842 1.0568640 0.2835091 0.11406731 0.1423169 -1.8618993 0.07843333 0.08900000 0.03576667 -0.05323333 0.5488622818 0.0005646918 TRUE TRUE
MSTRG.8334.16 ENSG00000185684 HEK293_OSMI2_6hA HEK293_TMG_6hB EP400P1 transcribed_unprocessed_pseudogene   10.01058 11.84309 7.655863 0.1942362 0.2979247 -0.6287432 1.7530623 1.8950680 2.1608167 0.32078730 0.1524120 0.1883954 0.19167917 0.16053333 0.28166667 0.12113333 0.1980812973 0.0005646918 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000185684 E001 0.3032425 0.024441170 4.949435e-01   12 132084275 132084276 2 + 0.000 0.156 18.457
ENSG00000185684 E002 0.3032425 0.024441170 4.949435e-01   12 132084277 132084282 6 + 0.000 0.156 18.459
ENSG00000185684 E003 0.3032425 0.024441170 4.949435e-01   12 132084283 132084284 2 + 0.000 0.156 18.459
ENSG00000185684 E004 0.4756169 0.022319454 2.774248e-01   12 132084285 132084289 5 + 0.000 0.217 19.045
ENSG00000185684 E005 0.4756169 0.022319454 2.774248e-01   12 132084290 132084290 1 + 0.000 0.217 19.045
ENSG00000185684 E006 0.7491197 0.017267182 5.481956e-01   12 132084291 132084294 4 + 0.171 0.270 0.835
ENSG00000185684 E007 1.2550964 0.013340189 1.977527e-01   12 132084295 132084298 4 + 0.171 0.399 1.643
ENSG00000185684 E008 2.2255437 0.009369054 2.396178e-02 1.089784e-01 12 132084299 132084301 3 + 0.171 0.580 2.536
ENSG00000185684 E009 2.9342547 0.008194032 5.655428e-03 3.801944e-02 12 132084302 132084302 1 + 0.171 0.669 2.924
ENSG00000185684 E010 5.3020053 0.031442213 7.440587e-04 7.811760e-03 12 132084303 132084312 10 + 0.294 0.893 2.818
ENSG00000185684 E011 6.1721320 0.021044184 6.711766e-04 7.193513e-03 12 132084313 132084314 2 + 0.389 0.940 2.411
ENSG00000185684 E012 7.4873280 0.010556280 3.572210e-05 6.259864e-04 12 132084315 132084319 5 + 0.389 1.019 2.705
ENSG00000185684 E013 8.6910570 0.017511567 5.159374e-05 8.548934e-04 12 132084320 132084324 5 + 0.467 1.069 2.474
ENSG00000185684 E014 10.5208600 0.035086251 7.422590e-04 7.799322e-03 12 132084325 132084330 6 + 0.642 1.129 1.879
ENSG00000185684 E015 13.5647010 0.071201446 4.678966e-02 1.720352e-01 12 132084331 132084343 13 + 0.918 1.197 1.018
ENSG00000185684 E016 20.5845035 0.011518919 1.621754e-03 1.447475e-02 12 132084344 132084399 56 + 1.083 1.372 1.019
ENSG00000185684 E017 25.1405113 0.007726526 2.027631e-01 4.330265e-01 12 132084480 132084962 483 + 1.337 1.415 0.271
ENSG00000185684 E018 10.5034339 0.003467524 3.377214e-01 5.760748e-01 12 132084963 132084963 1 + 0.986 1.062 0.278
ENSG00000185684 E019 36.0396085 0.005255749 5.258033e-01 7.191113e-01 12 132084964 132085065 102 + 1.529 1.541 0.038
ENSG00000185684 E020 45.4990483 0.008156500 4.517807e-01 6.669528e-01 12 132085066 132085225 160 + 1.619 1.640 0.073
ENSG00000185684 E021 23.8779797 0.015133601 9.061682e-01 9.551550e-01 12 132085226 132085256 31 + 1.392 1.354 -0.132
ENSG00000185684 E022 34.1249951 0.014378000 5.405116e-01 7.293591e-01 12 132085257 132085316 60 + 1.497 1.518 0.072
ENSG00000185684 E023 3.3879199 0.007606504 1.628951e-01 3.810901e-01 12 132085405 132085408 4 + 0.765 0.528 -1.024
ENSG00000185684 E024 14.4224514 0.002479651 1.705844e-09 9.535603e-08 12 132085409 132085797 389 + 1.462 0.898 -2.021
ENSG00000185684 E025 1.8963334 0.012649825 5.105055e-01 7.083550e-01 12 132088420 132088520 101 + 0.533 0.399 -0.679
ENSG00000185684 E026 2.8378936 0.038494566 8.013738e-01 8.971318e-01 12 132090651 132090848 198 + 0.591 0.530 -0.280
ENSG00000185684 E027 24.9080009 0.025268019 3.749143e-01 6.081255e-01 12 132090849 132090898 50 + 1.330 1.400 0.241
ENSG00000185684 E028 25.9726069 0.014773157 1.997573e-01 4.293856e-01 12 132090899 132090943 45 + 1.330 1.423 0.325
ENSG00000185684 E029 5.9390036 0.004896795 4.252040e-01 6.474207e-01 12 132091395 132091468 74 + 0.766 0.847 0.319
ENSG00000185684 E030 5.9047519 0.004483847 2.853045e-01 5.258950e-01 12 132091469 132091516 48 + 0.728 0.847 0.473
ENSG00000185684 E031 20.3976351 0.010766329 4.063401e-01 6.332951e-01 12 132103997 132104020 24 + 1.265 1.309 0.154
ENSG00000185684 E032 45.3310856 0.010766048 1.073358e-02 6.125649e-02 12 132104021 132104170 150 + 1.517 1.676 0.541
ENSG00000185684 E033 5.8243389 0.056254797 6.040849e-01 7.729270e-01 12 132104171 132104374 204 + 0.863 0.775 -0.342
ENSG00000185684 E034 3.0087951 0.008348648 5.732026e-01 7.524677e-01 12 132104375 132104377 3 + 0.533 0.604 0.321
ENSG00000185684 E035 23.1943059 0.001759576 1.168120e-03 1.118543e-02 12 132104378 132104566 189 + 1.176 1.414 0.834
ENSG00000185684 E036 29.0776977 0.014825780 6.030957e-03 3.987348e-02 12 132104567 132104949 383 + 1.276 1.508 0.804
ENSG00000185684 E037 90.0341086 0.044239256 5.842138e-01 7.598312e-01 12 132104950 132105304 355 + 1.899 1.932 0.110
ENSG00000185684 E038 57.7147769 0.023810306 2.202715e-01 4.538548e-01 12 132108572 132108682 111 + 1.672 1.755 0.283
ENSG00000185684 E039 28.0821594 0.026939148 1.578047e-03 1.416418e-02 12 132108683 132108899 217 + 1.188 1.499 1.083
ENSG00000185684 E040 7.4450970 0.133620867 1.414720e-01 3.497066e-01 12 132109768 132109832 65 + 1.069 0.782 -1.083
ENSG00000185684 E041 15.9635122 0.027228118 2.801151e-03 2.219418e-02 12 132114458 132114545 88 + 1.408 1.051 -1.263
ENSG00000185684 E042 1.0175630 0.015573736 3.902412e-01   12 132115198 132115291 94 + 0.171 0.318 1.158
ENSG00000185684 E043 1.7499422 0.060362736 3.877691e-01 6.187248e-01 12 132118146 132118830 685 + 0.535 0.359 -0.918
ENSG00000185684 E044 1.5515120 0.339546831 8.877342e-01 9.454541e-01 12 132118831 132119196 366 + 0.382 0.399 0.093
ENSG00000185684 E045 27.6696744 0.048704709 1.954933e-02 9.435896e-02 12 132120420 132120601 182 + 1.605 1.307 -1.026
ENSG00000185684 E046 22.1362564 0.044562792 2.499963e-02 1.122201e-01 12 132121440 132121579 140 + 1.505 1.229 -0.960
ENSG00000185684 E047 0.0000000       12 132121690 132121765 76 +      
ENSG00000185684 E048 10.7202672 0.004653492 3.005735e-02 1.275183e-01 12 132121925 132121980 56 + 1.203 0.952 -0.909
ENSG00000185684 E049 5.5394678 0.120403326 6.208210e-02 2.074652e-01 12 132121981 132123580 1600 + 0.987 0.652 -1.318
ENSG00000185684 E050 26.5835539 0.057262076 5.392850e-02 1.889283e-01 12 132125194 132125396 203 + 1.571 1.307 -0.910
ENSG00000185684 E051 0.1426347 0.031688573 2.352343e-01   12 132125397 132125408 12 + 0.171 0.000 -19.821
ENSG00000185684 E052 32.2195550 0.042256339 8.377674e-02 2.523272e-01 12 132125854 132126047 194 + 1.623 1.410 -0.729
ENSG00000185684 E053 10.1823461 0.026313568 2.802626e-01 5.204009e-01 12 132126048 132126340 293 + 1.117 0.963 -0.562
ENSG00000185684 E054 12.8956472 0.021488021 1.822544e-02 8.977301e-02 12 132126376 132126434 59 + 1.304 1.002 -1.082
ENSG00000185684 E055 43.8373581 0.030178352 1.089657e-02 6.192858e-02 12 132126435 132127080 646 + 1.787 1.519 -0.909
ENSG00000185684 E056 18.3676862 0.075915639 3.087594e-02 1.299716e-01 12 132127081 132127197 117 + 1.450 1.131 -1.119
ENSG00000185684 E057 56.7012447 0.028448342 2.665920e-02 1.172432e-01 12 132127198 132128097 900 + 1.867 1.651 -0.727
ENSG00000185684 E058 61.9085525 0.660471282 7.447406e-01 8.635231e-01 12 132128098 132128759 662 + 1.847 1.721 -0.427
ENSG00000185684 E059 240.2692609 1.369404371 6.287344e-01 7.896752e-01 12 132128760 132131639 2880 + 2.356 2.342 -0.044