ENSG00000185627

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000532097 ENSG00000185627 HEK293_OSMI2_6hA HEK293_TMG_6hB PSMD13 protein_coding protein_coding 143.2261 104.3834 125.7199 17.35298 4.358072 0.268298 127.9841 94.19551 104.1501 16.40425 4.0134 0.1449192 0.8878458 0.8994 0.8283333 -0.07106667 0.03612243 0.03612243 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000185627 E001 4.179066 0.0064520358 1.258228e-01 3.252051e-01 11 236966 236975 10 + 0.810 0.593 -0.900
ENSG00000185627 E002 5.543181 0.0051638928 4.351838e-02 1.639022e-01 11 236976 236976 1 + 0.923 0.660 -1.045
ENSG00000185627 E003 8.453561 0.0036102795 2.206194e-01 4.542093e-01 11 236977 236980 4 + 1.026 0.894 -0.494
ENSG00000185627 E004 137.247984 0.0016922580 5.548866e-03 3.746670e-02 11 236981 236999 19 + 2.069 2.184 0.383
ENSG00000185627 E005 143.639622 0.0019887381 3.093347e-03 2.397852e-02 11 237000 237003 4 + 2.083 2.208 0.416
ENSG00000185627 E006 227.529201 0.0005204212 3.504348e-03 2.637120e-02 11 237004 237025 22 + 2.305 2.389 0.281
ENSG00000185627 E007 260.948482 0.0013263536 1.458151e-03 1.332190e-02 11 237026 237037 12 + 2.355 2.459 0.346
ENSG00000185627 E008 511.100784 0.0003668097 3.353482e-01 5.738828e-01 11 237038 237144 107 + 2.688 2.714 0.088
ENSG00000185627 E009 594.478411 0.0005391975 5.527890e-01 7.382492e-01 11 238998 239076 79 + 2.758 2.779 0.068
ENSG00000185627 E010 404.037771 0.0001374283 2.019813e-03 1.719266e-02 11 244041 244075 35 + 2.624 2.573 -0.167
ENSG00000185627 E011 36.186080 0.0010444077 9.013576e-04 9.105534e-03 11 244076 244160 85 + 1.649 1.457 -0.658
ENSG00000185627 E012 543.343810 0.0001086170 1.338160e-09 7.623293e-08 11 244161 244216 56 + 2.769 2.681 -0.296
ENSG00000185627 E013 24.809106 0.0362227222 5.913428e-02 2.008400e-01 11 244217 244425 209 + 1.493 1.303 -0.657
ENSG00000185627 E014 405.870166 0.0001465264 8.580405e-10 5.080719e-08 11 244426 244428 3 + 2.651 2.545 -0.352
ENSG00000185627 E015 572.429738 0.0002351155 5.176706e-11 3.884771e-09 11 244429 244469 41 + 2.797 2.699 -0.328
ENSG00000185627 E016 613.209659 0.0002419738 6.394723e-10 3.863291e-08 11 244675 244705 31 + 2.822 2.733 -0.297
ENSG00000185627 E017 656.614946 0.0009298004 2.244314e-04 2.941546e-03 11 244706 244761 56 + 2.839 2.783 -0.187
ENSG00000185627 E018 934.299961 0.0003183819 5.435068e-01 7.315581e-01 11 247277 247448 172 + 2.962 2.964 0.006
ENSG00000185627 E019 54.039966 0.0092010177 8.902200e-06 1.898052e-04 11 247449 248197 749 + 1.859 1.571 -0.975
ENSG00000185627 E020 24.142541 0.0016658241 1.390314e-07 4.999098e-06 11 248607 248775 169 + 1.552 1.165 -1.345
ENSG00000185627 E021 717.082023 0.0001400430 8.754036e-02 2.591611e-01 11 248776 248855 80 + 2.830 2.861 0.104
ENSG00000185627 E022 19.110097 0.0035187808 1.182880e-03 1.130128e-02 11 248856 248931 76 + 1.410 1.146 -0.927
ENSG00000185627 E023 864.999354 0.0012726695 2.542996e-01 4.927542e-01 11 248932 249057 126 + 2.912 2.951 0.130
ENSG00000185627 E024 4.869041 0.0261672091 8.257938e-01 9.113693e-01 11 250784 250802 19 + 0.765 0.747 -0.074
ENSG00000185627 E025 462.069784 0.0005560537 2.348540e-03 1.936756e-02 11 250803 250815 13 + 2.620 2.689 0.231
ENSG00000185627 E026 623.267269 0.0001654177 1.378496e-02 7.348011e-02 11 250816 250865 50 + 2.763 2.807 0.145
ENSG00000185627 E027 10.281108 0.0653394086 3.941493e-01 6.236630e-01 11 250866 251226 361 + 1.087 1.010 -0.280
ENSG00000185627 E028 8.300427 0.0929513264 1.569625e-01 3.721999e-01 11 251227 251340 114 + 1.060 0.859 -0.752
ENSG00000185627 E029 7.917482 0.0173834859 5.341091e-02 1.876975e-01 11 251341 251542 202 + 1.051 0.816 -0.884
ENSG00000185627 E030 4.649126 0.0058503242 7.162576e-01 8.457763e-01 11 251543 251545 3 + 0.764 0.719 -0.184
ENSG00000185627 E031 815.599386 0.0001204498 3.591131e-02 1.439744e-01 11 251546 251626 81 + 2.886 2.920 0.111
ENSG00000185627 E032 13.060812 0.0036510041 6.622242e-01 8.112423e-01 11 251627 251819 193 + 1.160 1.126 -0.124
ENSG00000185627 E033 916.728214 0.0007215480 2.169346e-02 1.015701e-01 11 251820 251936 117 + 2.932 2.981 0.165
ENSG00000185627 E034 22.966492 0.0138787953 2.094482e-02 9.916466e-02 11 251937 252504 568 + 1.240 1.471 0.803
ENSG00000185627 E035 1264.382638 0.0021426983 3.786976e-05 6.582555e-04 11 252505 252984 480 + 3.042 3.150 0.359