ENSG00000185619

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000362003 ENSG00000185619 HEK293_OSMI2_6hA HEK293_TMG_6hB PCGF3 protein_coding protein_coding 21.66693 21.53369 20.63109 0.77789 0.3519266 -0.06174577 6.7236825 5.0750250 7.542280 0.34507767 0.4360051 0.5706573 0.30970000 0.23556667 0.3661000 0.13053333 0.053055500 0.000876076 FALSE TRUE
ENST00000400151 ENSG00000185619 HEK293_OSMI2_6hA HEK293_TMG_6hB PCGF3 protein_coding protein_coding 21.66693 21.53369 20.63109 0.77789 0.3519266 -0.06174577 6.0905395 9.9598622 3.446055 1.44353377 0.4744035 -1.5284473 0.28464583 0.45890000 0.1664667 -0.29243333 0.000876076 0.000876076 FALSE TRUE
ENST00000430644 ENSG00000185619 HEK293_OSMI2_6hA HEK293_TMG_6hB PCGF3 protein_coding nonsense_mediated_decay 21.66693 21.53369 20.63109 0.77789 0.3519266 -0.06174577 0.5876244 0.3281515 1.580902 0.18025667 0.5382410 2.2341031 0.02835000 0.01556667 0.0760000 0.06043333 0.422683630 0.000876076 FALSE TRUE
MSTRG.24416.4 ENSG00000185619 HEK293_OSMI2_6hA HEK293_TMG_6hB PCGF3 protein_coding   21.66693 21.53369 20.63109 0.77789 0.3519266 -0.06174577 1.4543135 0.7987551 1.639385 0.08299279 0.2477665 1.0281535 0.06704167 0.03703333 0.0792000 0.04216667 0.079259147 0.000876076 FALSE TRUE
MSTRG.24416.6 ENSG00000185619 HEK293_OSMI2_6hA HEK293_TMG_6hB PCGF3 protein_coding   21.66693 21.53369 20.63109 0.77789 0.3519266 -0.06174577 1.2529105 0.0000000 2.170536 0.00000000 1.0878958 7.7685391 0.05525417 0.00000000 0.1039667 0.10396667 0.268796126 0.000876076 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000185619 E001 0.6673924 0.0189265708 3.879453e-01   4 705748 705764 17 + 0.136 0.268 1.217
ENSG00000185619 E002 0.6673924 0.0189265708 3.879453e-01   4 705765 705779 15 + 0.136 0.268 1.217
ENSG00000185619 E003 0.7982606 0.0171296784 2.273869e-01   4 705780 705781 2 + 0.136 0.329 1.631
ENSG00000185619 E004 0.7982606 0.0171296784 2.273869e-01   4 705782 705783 2 + 0.136 0.329 1.631
ENSG00000185619 E005 1.1318630 0.0149485294 7.611472e-02   4 705784 705791 8 + 0.136 0.432 2.216
ENSG00000185619 E006 3.3687455 0.0812326658 2.848401e-03 2.249042e-02 4 705792 705807 16 + 0.239 0.815 2.910
ENSG00000185619 E007 4.9355269 0.0747754952 7.368225e-03 4.640094e-02 4 705808 705831 24 + 0.453 0.927 2.024
ENSG00000185619 E008 38.8359814 0.0246696229 4.263966e-03 3.062730e-02 4 705832 705874 43 + 1.449 1.686 0.810
ENSG00000185619 E009 71.3102383 0.0197029220 3.459437e-02 1.404878e-01 4 705875 705942 68 + 1.777 1.907 0.439
ENSG00000185619 E010 67.4327869 0.0193988694 7.834450e-02 2.414909e-01 4 705943 705970 28 + 1.770 1.871 0.343
ENSG00000185619 E011 0.0000000       4 725107 725229 123 +      
ENSG00000185619 E012 76.3450761 0.0108914539 2.586276e-02 1.148589e-01 4 730630 730668 39 + 1.822 1.927 0.354
ENSG00000185619 E013 1.2663856 0.5014687482 8.471203e-01   4 730952 730969 18 + 0.381 0.367 -0.083
ENSG00000185619 E014 133.5826435 0.0143213256 8.748589e-02 2.590876e-01 4 730970 731110 141 + 2.083 2.154 0.238
ENSG00000185619 E015 6.7749754 0.1033058907 8.024672e-01 8.977291e-01 4 731111 731345 235 + 0.858 0.910 0.196
ENSG00000185619 E016 7.8053754 0.0519750358 4.567841e-01 6.708524e-01 4 732400 732443 44 + 1.011 0.863 -0.556
ENSG00000185619 E017 11.1170920 0.0586740622 9.331997e-01 9.687622e-01 4 732444 732498 55 + 1.097 1.047 -0.180
ENSG00000185619 E018 64.8217210 0.0007580312 8.138790e-03 4.996579e-02 4 733672 733674 3 + 1.773 1.847 0.249
ENSG00000185619 E019 162.2067720 0.0053708799 1.079734e-02 6.151492e-02 4 733675 733789 115 + 2.166 2.237 0.237
ENSG00000185619 E020 72.4426885 0.0127031159 1.605560e-10 1.091517e-08 4 733790 733883 94 + 1.577 1.994 1.407
ENSG00000185619 E021 209.4212855 0.0171078755 1.879781e-04 2.540427e-03 4 733884 734789 906 + 2.191 2.394 0.677
ENSG00000185619 E022 28.1603585 0.1619007035 5.227476e-02 1.850125e-01 4 734790 734930 141 + 1.636 1.258 -1.304
ENSG00000185619 E023 106.2118352 0.0088140163 3.425006e-04 4.162932e-03 4 734931 735027 97 + 2.145 1.908 -0.794
ENSG00000185619 E024 96.2516154 0.0214454227 2.946004e-03 2.307547e-02 4 737466 737521 56 + 2.114 1.851 -0.885
ENSG00000185619 E025 0.2735028 0.0261030877 9.118696e-01   4 737522 737540 19 + 0.136 0.108 -0.370
ENSG00000185619 E026 111.6472682 0.0044862206 1.254026e-05 2.552588e-04 4 743474 743584 111 + 2.168 1.929 -0.801
ENSG00000185619 E027 0.1723744 0.0331755845 5.596297e-01   4 743865 743952 88 + 0.000 0.109 9.135
ENSG00000185619 E028 76.6123878 0.0044128697 1.405006e-01 3.482738e-01 4 744600 744688 89 + 1.954 1.831 -0.415
ENSG00000185619 E029 81.9738322 0.8511237777 5.367278e-01 7.268507e-01 4 761279 761416 138 + 1.917 1.913 -0.013
ENSG00000185619 E030 17.1694658 0.0969661347 1.235594e-02 6.786078e-02 4 761730 762369 640 + 1.028 1.375 1.232
ENSG00000185619 E031 74.9771009 0.8382520702 5.801811e-01 7.572793e-01 4 764984 765064 81 + 1.898 1.859 -0.131
ENSG00000185619 E032 42.2000320 0.3937474705 4.101614e-01 6.361134e-01 4 766032 766034 3 + 1.607 1.649 0.143
ENSG00000185619 E033 162.7192461 0.2261872641 6.664254e-01 8.139478e-01 4 766035 766405 371 + 2.246 2.181 -0.216
ENSG00000185619 E034 71.2047367 0.8096412729 5.498557e-01 7.361711e-01 4 766406 766673 268 + 1.866 1.846 -0.068
ENSG00000185619 E035 300.4576710 0.0292794629 1.939535e-01 4.220789e-01 4 766674 768188 1515 + 2.563 2.396 -0.555
ENSG00000185619 E036 361.9120193 0.0339484122 3.860982e-02 1.511366e-01 4 768189 770640 2452 + 2.660 2.455 -0.685