ENSG00000185480

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327680 ENSG00000185480 HEK293_OSMI2_6hA HEK293_TMG_6hB PARPBP protein_coding protein_coding 11.51181 2.130142 24.98028 0.1847984 0.3323827 3.545589 4.0660078 0.81123542 7.1832974 0.09500422 0.13058812 3.130785 0.29141667 0.3791667 0.28756667 -0.09160000 3.801979e-01 3.853864e-05 FALSE TRUE
ENST00000535811 ENSG00000185480 HEK293_OSMI2_6hA HEK293_TMG_6hB PARPBP protein_coding processed_transcript 11.51181 2.130142 24.98028 0.1847984 0.3323827 3.545589 0.4412406 0.00000000 0.2869051 0.00000000 0.28690505 4.891930 0.11272083 0.0000000 0.01180000 0.01180000 1.000000e+00 3.853864e-05 FALSE FALSE
ENST00000541668 ENSG00000185480 HEK293_OSMI2_6hA HEK293_TMG_6hB PARPBP protein_coding processed_transcript 11.51181 2.130142 24.98028 0.1847984 0.3323827 3.545589 1.1847065 0.54535083 2.0454830 0.04449033 0.07519151 1.888006 0.14830000 0.2570667 0.08200000 -0.17506667 3.853864e-05 3.853864e-05 FALSE TRUE
ENST00000543784 ENSG00000185480 HEK293_OSMI2_6hA HEK293_TMG_6hB PARPBP protein_coding protein_coding 11.51181 2.130142 24.98028 0.1847984 0.3323827 3.545589 0.4761653 0.00000000 1.7095873 0.00000000 0.43821079 7.425919 0.02670000 0.0000000 0.06886667 0.06886667 7.417270e-03 3.853864e-05 FALSE TRUE
MSTRG.7879.10 ENSG00000185480 HEK293_OSMI2_6hA HEK293_TMG_6hB PARPBP protein_coding   11.51181 2.130142 24.98028 0.1847984 0.3323827 3.545589 1.2857148 0.09279252 4.0541833 0.09279252 2.02801338 5.305158 0.07659167 0.0500000 0.16333333 0.11333333 7.844538e-01 3.853864e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000185480 E001 0.0000000       12 102120125 102120156 32 +      
ENSG00000185480 E002 0.2027342 0.042375630 0.0388148779   12 102120157 102120182 26 + 0.000 0.284 12.164
ENSG00000185480 E003 0.2027342 0.042375630 0.0388148779   12 102120183 102120184 2 + 0.000 0.284 12.176
ENSG00000185480 E004 0.6659874 0.026005598 0.3977353745   12 102120185 102120194 10 + 0.127 0.284 1.442
ENSG00000185480 E005 4.0220428 0.007052653 0.1919467273 0.419320756 12 102120195 102120203 9 + 0.514 0.748 1.022
ENSG00000185480 E006 17.9330032 0.045186434 0.7334896034 0.856327237 12 102120204 102120244 41 + 1.081 1.143 0.223
ENSG00000185480 E007 20.3637566 0.045796989 0.9368403924 0.970639754 12 102120245 102120246 2 + 1.141 1.142 0.005
ENSG00000185480 E008 38.8425710 0.043984604 0.4650499026 0.676600297 12 102120247 102120286 40 + 1.415 1.328 -0.301
ENSG00000185480 E009 2.0809222 0.016397562 0.2224970506 0.456468785 12 102120383 102120491 109 + 0.329 0.575 1.285
ENSG00000185480 E010 56.0618135 0.046182366 0.1270322117 0.327076600 12 102123886 102123987 102 + 1.578 1.394 -0.633
ENSG00000185480 E011 56.8712434 0.041781869 0.0863214073 0.257055488 12 102123988 102124041 54 + 1.586 1.379 -0.709
ENSG00000185480 E012 29.3358695 0.035401142 0.4094095118 0.635607079 12 102148230 102148234 5 + 1.301 1.196 -0.367
ENSG00000185480 E013 96.0951447 0.028549337 0.1857570476 0.411562044 12 102148235 102148463 229 + 1.801 1.683 -0.400
ENSG00000185480 E014 2.6059402 0.080157168 0.4333159645 0.653696531 12 102148464 102149007 544 + 0.395 0.574 0.888
ENSG00000185480 E015 1.4486753 0.017987316 0.3283962055 0.567412057 12 102150264 102150371 108 + 0.253 0.454 1.220
ENSG00000185480 E016 5.6667116 0.052577322 0.6452305868 0.800364549 12 102151570 102151800 231 + 0.653 0.747 0.392
ENSG00000185480 E017 3.1155013 0.121889018 0.2999826374 0.540387507 12 102151801 102152012 212 + 0.435 0.669 1.091
ENSG00000185480 E018 71.4040406 0.024960265 0.7948525525 0.893243282 12 102153869 102153976 108 + 1.664 1.649 -0.051
ENSG00000185480 E019 2.6784241 0.008712634 0.1412527780 0.349388562 12 102153977 102153989 13 + 0.393 0.670 1.325
ENSG00000185480 E020 13.8173608 0.004037682 0.0005375219 0.006015392 12 102154827 102154996 170 + 0.922 1.308 1.395
ENSG00000185480 E021 12.8896420 0.006007778 0.0007831362 0.008140905 12 102154997 102155280 284 + 0.898 1.287 1.413
ENSG00000185480 E022 53.6857249 0.020077553 0.3073049025 0.547911142 12 102164438 102164538 101 + 1.551 1.457 -0.326
ENSG00000185480 E023 50.7512600 0.010675746 0.7218324299 0.849176680 12 102164539 102164608 70 + 1.522 1.496 -0.089
ENSG00000185480 E024 88.4703508 0.012891768 0.0581641772 0.198656052 12 102165729 102165883 155 + 1.769 1.625 -0.487
ENSG00000185480 E025 39.4007269 0.022081462 0.9009866488 0.952346154 12 102175483 102175666 184 + 1.408 1.430 0.075
ENSG00000185480 E026 37.0456104 0.035727712 0.3011678040 0.541632644 12 102178592 102178770 179 + 1.368 1.499 0.451
ENSG00000185480 E027 48.1334198 0.003123331 0.9800567153 0.991830922 12 102182549 102182627 79 + 1.499 1.496 -0.009
ENSG00000185480 E028 35.0064163 0.023702621 0.7374919210 0.858941304 12 102195312 102195447 136 + 1.361 1.383 0.076
ENSG00000185480 E029 68.7332478 0.322089190 0.5680733122 0.748842752 12 102195951 102196087 137 + 1.648 1.641 -0.026
ENSG00000185480 E030 100.5246711 1.393444611 0.5430930836 0.731262943 12 102196088 102196548 461 + 1.799 1.884 0.287
ENSG00000185480 E031 147.0669515 1.405164951 0.5716696201 0.751453980 12 102196549 102197520 972 + 1.964 2.032 0.229