ENSG00000185344

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330342 ENSG00000185344 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP6V0A2 protein_coding protein_coding 16.10862 8.35527 24.73311 0.2242252 0.8300947 1.564543 7.9342546 4.1179461 11.351407 0.65803292 0.15720675 1.4606455 0.48515833 0.49666667 0.46020000 -0.03646667 9.570638e-01 3.249641e-08 FALSE TRUE
ENST00000536426 ENSG00000185344 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP6V0A2 protein_coding processed_transcript 16.10862 8.35527 24.73311 0.2242252 0.8300947 1.564543 1.2518989 0.0000000 2.655985 0.00000000 0.74734875 8.0585246 0.05077083 0.00000000 0.10570000 0.10570000 3.249641e-08 3.249641e-08 FALSE FALSE
ENST00000540368 ENSG00000185344 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP6V0A2 protein_coding retained_intron 16.10862 8.35527 24.73311 0.2242252 0.8300947 1.564543 3.5461963 1.7958830 6.729706 0.28889395 0.15051195 1.8999813 0.21249583 0.21363333 0.27260000 0.05896667 6.468490e-01 3.249641e-08 FALSE TRUE
ENST00000543687 ENSG00000185344 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP6V0A2 protein_coding retained_intron 16.10862 8.35527 24.73311 0.2242252 0.8300947 1.564543 1.3865573 1.0713593 1.405515 0.07305362 0.08168692 0.3884815 0.11180000 0.12830000 0.05693333 -0.07136667 6.669278e-03 3.249641e-08 FALSE FALSE
ENST00000675260 ENSG00000185344 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP6V0A2 protein_coding retained_intron 16.10862 8.35527 24.73311 0.2242252 0.8300947 1.564543 0.9023285 0.6408339 1.459232 0.22579583 0.12895844 1.1747006 0.06001250 0.07563333 0.05890000 -0.01673333 9.137699e-01 3.249641e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000185344 E001 0.0000000       12 123712353 123712355 3 +      
ENSG00000185344 E002 3.6918459 0.1497746960 2.700086e-02 0.1183045974 12 123712356 123712446 91 + 0.420 0.951 2.285
ENSG00000185344 E003 15.0126722 0.0192280790 2.477243e-02 0.1115245426 12 123712447 123712534 88 + 1.064 1.350 1.017
ENSG00000185344 E004 23.1060210 0.0023439210 1.489487e-01 0.3607796611 12 123712535 123712582 48 + 1.292 1.448 0.542
ENSG00000185344 E005 52.1431121 0.0008102983 9.984691e-01 1.0000000000 12 123712583 123712682 100 + 1.673 1.720 0.160
ENSG00000185344 E006 62.1234012 0.0005898903 4.775246e-02 0.1744308902 12 123718623 123718701 79 + 1.772 1.721 -0.173
ENSG00000185344 E007 0.0000000       12 123718702 123719576 875 +      
ENSG00000185344 E008 90.7181088 0.0004636613 1.816992e-02 0.0895851404 12 123722351 123722448 98 + 1.934 1.884 -0.168
ENSG00000185344 E009 1.4646232 0.1240474089 9.153295e-01 0.9598015226 12 123723210 123724653 1444 + 0.347 0.406 0.339
ENSG00000185344 E010 129.4958508 0.0003067979 7.419637e-04 0.0077967017 12 123724654 123724791 138 + 2.093 2.024 -0.231
ENSG00000185344 E011 108.4135982 0.0003910654 2.979940e-04 0.0037098632 12 123726197 123726285 89 + 2.021 1.931 -0.304
ENSG00000185344 E012 78.1956481 0.0005792192 2.087276e-03 0.0176501294 12 123727783 123727821 39 + 1.885 1.794 -0.306
ENSG00000185344 E013 98.3908233 0.0004047708 9.219585e-04 0.0092782079 12 123727822 123727909 88 + 1.980 1.895 -0.284
ENSG00000185344 E014 1.0398556 0.8491347709 2.970523e-01   12 123730642 123733925 3284 + 0.082 0.563 3.667
ENSG00000185344 E015 102.4770017 0.0014818729 2.566880e-03 0.0207638035 12 123733926 123734008 83 + 1.994 1.914 -0.267
ENSG00000185344 E016 116.1222987 0.0017461734 2.817569e-03 0.0223029776 12 123735531 123735624 94 + 2.047 1.972 -0.249
ENSG00000185344 E017 0.1723744 0.0326195403 2.150791e-01   12 123735893 123736540 648 + 0.000 0.179 11.314
ENSG00000185344 E018 153.5090662 0.0049143660 3.072377e-02 0.1295166745 12 123737059 123737271 213 + 2.161 2.111 -0.167
ENSG00000185344 E019 0.7685209 0.0185785666 1.862962e-01   12 123737272 123737644 373 + 0.148 0.403 1.907
ENSG00000185344 E020 0.0000000       12 123738959 123739013 55 +      
ENSG00000185344 E021 0.0000000       12 123742029 123742093 65 +      
ENSG00000185344 E022 0.6765862 0.2171039502 2.397375e-01   12 123743472 123743784 313 + 0.262 0.000 -11.302
ENSG00000185344 E023 118.6519611 0.0061479271 2.690786e-03 0.0215170365 12 123743785 123743935 151 + 2.064 1.952 -0.373
ENSG00000185344 E024 123.6636728 0.0003786881 2.587267e-03 0.0208852375 12 123744201 123744337 137 + 2.070 2.011 -0.198
ENSG00000185344 E025 139.4358754 0.0003930267 3.849594e-03 0.0283057465 12 123744597 123744784 188 + 2.120 2.071 -0.163
ENSG00000185344 E026 99.3441034 0.0004029654 1.269639e-01 0.3269452686 12 123744882 123744972 91 + 1.963 1.951 -0.040
ENSG00000185344 E027 103.7486309 0.0004649334 8.149649e-02 0.2478284267 12 123747607 123747725 119 + 1.982 1.963 -0.065
ENSG00000185344 E028 0.0000000       12 123747726 123747726 1 +      
ENSG00000185344 E029 145.2788097 0.0023394451 1.763254e-01 0.3988717719 12 123748575 123748785 211 + 2.123 2.117 -0.019
ENSG00000185344 E030 6.0229594 0.1887660549 2.847081e-01 0.5252548240 12 123749996 123751109 1114 + 0.668 1.027 1.401
ENSG00000185344 E031 108.1619831 0.0004005253 9.702500e-01 0.9869880572 12 123751110 123751229 120 + 1.981 2.030 0.163
ENSG00000185344 E032 116.6706010 0.0100806888 6.531676e-01 0.8055167773 12 123752283 123752402 120 + 2.009 2.079 0.233
ENSG00000185344 E033 22.9973991 0.0916202647 4.520992e-01 0.6672533660 12 123752403 123753116 714 + 1.262 1.488 0.786
ENSG00000185344 E034 16.5593347 0.1251290901 2.732830e-01 0.5131437216 12 123753991 123754419 429 + 1.111 1.384 0.960
ENSG00000185344 E035 89.7533446 1.3255473122 4.401936e-01 0.6588605566 12 123754420 123754537 118 + 1.816 2.094 0.932
ENSG00000185344 E036 49.7797905 0.0529832826 1.226671e-02 0.0675123354 12 123754538 123755441 904 + 1.523 1.892 1.249
ENSG00000185344 E037 31.5018895 0.0083841320 6.465290e-03 0.0420141177 12 123756327 123756814 488 + 1.378 1.633 0.874
ENSG00000185344 E038 130.0966571 0.0243569782 8.778955e-02 0.2596155884 12 123756815 123756986 172 + 2.018 2.197 0.597
ENSG00000185344 E039 792.2266035 0.0031111390 3.494937e-05 0.0006146652 12 123757927 123761755 3829 + 2.810 2.954 0.479