ENSG00000185164

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330537 ENSG00000185164 HEK293_OSMI2_6hA HEK293_TMG_6hB NOMO2 protein_coding protein_coding 107.749 134.8712 62.27656 11.80579 5.120294 -1.114697 32.23575 42.88168 12.888106 5.563653 2.955097 -1.733538552 0.2897333 0.3204667 0.2040000 -0.1164667 0.41437502 0.01628306 FALSE TRUE
ENST00000620440 ENSG00000185164 HEK293_OSMI2_6hA HEK293_TMG_6hB NOMO2 protein_coding protein_coding 107.749 134.8712 62.27656 11.80579 5.120294 -1.114697 39.18717 51.28203 7.540669 7.390124 3.770821 -2.764058132 0.2686333 0.3771000 0.1120333 -0.2650667 0.62649854 0.01628306 FALSE TRUE
ENST00000622306 ENSG00000185164 HEK293_OSMI2_6hA HEK293_TMG_6hB NOMO2 protein_coding protein_coding 107.749 134.8712 62.27656 11.80579 5.120294 -1.114697 33.51703 37.39384 37.641519 3.720919 1.798637 0.009521701 0.4103292 0.2768667 0.6173667 0.3405000 0.01628306 0.01628306 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000185164 E001 0.0000000       16 18417325 18417325 1 -      
ENSG00000185164 E002 0.0000000       16 18417326 18417329 4 -      
ENSG00000185164 E003 0.0000000       16 18417330 18417336 7 -      
ENSG00000185164 E004 0.0000000       16 18417337 18417509 173 -      
ENSG00000185164 E005 0.0000000       16 18417510 18417840 331 -      
ENSG00000185164 E006 0.0000000       16 18417841 18417968 128 -      
ENSG00000185164 E007 0.0000000       16 18418392 18418431 40 -      
ENSG00000185164 E008 0.1426347 0.0314720632 0.2578126900   16 18418432 18418484 53 - 0.160 0.000 -11.238
ENSG00000185164 E009 0.1426347 0.0314720632 0.2578126900   16 18424274 18424393 120 - 0.160 0.000 -13.500
ENSG00000185164 E010 0.0000000       16 18424394 18424765 372 -      
ENSG00000185164 E011 0.0000000       16 18426630 18426731 102 -      
ENSG00000185164 E012 0.0000000       16 18429010 18429120 111 -      
ENSG00000185164 E013 0.0000000       16 18430815 18430898 84 -      
ENSG00000185164 E014 0.0000000       16 18431807 18431948 142 -      
ENSG00000185164 E015 0.0000000       16 18433348 18433475 128 -      
ENSG00000185164 E016 0.2027342 0.0337341997 0.9255865200   16 18434654 18434767 114 - 0.000 0.091 11.586
ENSG00000185164 E017 0.0000000       16 18499925 18499926 2 -      
ENSG00000185164 E018 0.0000000       16 18499927 18499935 9 -      
ENSG00000185164 E019 0.0000000       16 18499936 18500108 173 -      
ENSG00000185164 E020 0.0000000       16 18500109 18500439 331 -      
ENSG00000185164 E021 0.0000000       16 18500440 18500567 128 -      
ENSG00000185164 E022 0.1426347 0.0314720632 0.2578126900   16 18500991 18501083 93 - 0.160 0.000 -13.500
ENSG00000185164 E023 0.1426347 0.0314720632 0.2578126900   16 18506873 18506992 120 - 0.160 0.000 -13.500
ENSG00000185164 E024 0.0000000       16 18509166 18509267 102 -      
ENSG00000185164 E025 0.0000000       16 18511546 18511656 111 -      
ENSG00000185164 E026 0.0000000       16 18513350 18513433 84 -      
ENSG00000185164 E027 0.0000000       16 18514342 18514483 142 -      
ENSG00000185164 E028 0.0000000       16 18515883 18516010 128 -      
ENSG00000185164 E029 0.2027342 0.0337341997 0.9255865200   16 18517189 18517302 114 - 0.000 0.091 11.586
ENSG00000185164 E030 11.4254516 0.0433877557 0.6047436004 0.773344471 16 18519229 18519355 127 - 0.999 1.087 0.320
ENSG00000185164 E031 94.3381528 0.0057918700 0.0992982488 0.280553110 16 18519501 18519660 160 - 1.893 1.981 0.297
ENSG00000185164 E032 160.2880902 0.0002785753 0.2338282491 0.469582415 16 18520597 18520679 83 - 2.157 2.191 0.112
ENSG00000185164 E033 305.9733710 0.0001951518 0.0562635259 0.194239612 16 18520765 18520819 55 - 2.434 2.473 0.129
ENSG00000185164 E034 336.0332239 0.0001798768 0.0830816229 0.250914450 16 18520820 18520898 79 - 2.478 2.511 0.110
ENSG00000185164 E035 127.2981595 0.0004219165 0.5034071700 0.703160255 16 18520899 18520983 85 - 2.068 2.088 0.069
ENSG00000185164 E036 75.0227530 0.0006538864 0.3715537489 0.605242749 16 18523844 18523939 96 - 1.824 1.862 0.127
ENSG00000185164 E037 29.8385496 0.0024455151 0.7828971529 0.886335986 16 18524489 18524552 64 - 1.445 1.463 0.061
ENSG00000185164 E038 18.0772900 0.0059266237 0.7155337783 0.845238989 16 18527537 18527624 88 - 1.277 1.244 -0.117
ENSG00000185164 E039 2.2351127 0.0901252009 0.5462243792 0.733611157 16 18528013 18528071 59 - 0.567 0.455 -0.541
ENSG00000185164 E040 0.0000000       16 18529409 18529500 92 -      
ENSG00000185164 E041 45.1929108 0.0008995341 0.0284878765 0.122776791 16 18529501 18529637 137 - 1.549 1.673 0.421
ENSG00000185164 E042 122.3729175 0.0037702859 0.6163861102 0.781325628 16 18531037 18531168 132 - 2.048 2.072 0.080
ENSG00000185164 E043 304.4164524 0.0002884360 0.3101711929 0.550651305 16 18531466 18531607 142 - 2.442 2.463 0.069
ENSG00000185164 E044 431.2814843 0.0001413768 0.1707226083 0.391452552 16 18533005 18533179 175 - 2.624 2.599 -0.085
ENSG00000185164 E045 296.6619388 0.0012409976 0.0517399708 0.183843936 16 18538526 18538629 104 - 2.480 2.429 -0.171
ENSG00000185164 E046 104.8358172 0.0060146971 0.0819268176 0.248628365 16 18538630 18538676 47 - 2.053 1.964 -0.298
ENSG00000185164 E047 92.3118275 0.0053991823 0.7498656423 0.866707273 16 18538859 18538964 106 - 1.955 1.937 -0.060
ENSG00000185164 E048 51.3487623 0.0036717912 0.9203401521 0.962395326 16 18542172 18542261 90 - 1.692 1.686 -0.022
ENSG00000185164 E049 122.9941356 0.0003861687 0.7703352663 0.878859622 16 18542594 18542731 138 - 2.058 2.066 0.027
ENSG00000185164 E050 0.0000000       16 18542732 18542942 211 -      
ENSG00000185164 E051 156.8413248 0.0003540756 0.0015857086 0.014221800 16 18543617 18543769 153 - 2.230 2.135 -0.317
ENSG00000185164 E052 45.1834142 0.0008907763 0.0004510145 0.005232095 16 18547228 18547300 73 - 1.755 1.566 -0.642
ENSG00000185164 E053 34.6882730 0.0045605410 0.2481435478 0.485994606 16 18549521 18549627 107 - 1.581 1.501 -0.271
ENSG00000185164 E054 16.5012437 0.0025286456 0.9374454349 0.970925833 16 18551439 18551472 34 - 1.210 1.214 0.018
ENSG00000185164 E055 69.1311779 0.0006006802 0.9478639690 0.976204678 16 18551473 18551539 67 - 1.816 1.816 0.003
ENSG00000185164 E056 71.3090738 0.0005189069 0.9672905471 0.985613038 16 18554807 18554852 46 - 1.830 1.830 -0.001
ENSG00000185164 E057 137.1311843 0.0003788950 0.6492297333 0.802987080 16 18557702 18557791 90 - 2.125 2.108 -0.055
ENSG00000185164 E058 0.1614157 0.0331529966 0.2572352961   16 18558677 18558854 178 - 0.161 0.000 -13.473
ENSG00000185164 E059 170.6491052 0.0003259057 0.1726731016 0.394037331 16 18561876 18562211 336 - 2.182 2.220 0.125