ENSG00000185133

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331075 ENSG00000185133 HEK293_OSMI2_6hA HEK293_TMG_6hB INPP5J protein_coding protein_coding 7.137841 10.06658 2.701806 1.083119 0.144865 -1.89368 2.29407851 3.36020196 1.0848621 0.74284724 0.12628521 -1.622086 0.33030000 0.329533333 0.40356667 0.074033333 0.8213416365 0.0003531986 FALSE TRUE
ENST00000404390 ENSG00000185133 HEK293_OSMI2_6hA HEK293_TMG_6hB INPP5J protein_coding protein_coding 7.137841 10.06658 2.701806 1.083119 0.144865 -1.89368 0.57936833 1.35275218 0.0000000 0.44580090 0.00000000 -7.090379 0.05505417 0.127866667 0.00000000 -0.127866667 0.0003531986 0.0003531986 FALSE TRUE
ENST00000404453 ENSG00000185133 HEK293_OSMI2_6hA HEK293_TMG_6hB INPP5J protein_coding protein_coding 7.137841 10.06658 2.701806 1.083119 0.144865 -1.89368 0.82340738 0.06819559 0.0000000 0.06819559 0.00000000 -2.967087 0.06951250 0.008233333 0.00000000 -0.008233333 1.0000000000 0.0003531986 FALSE TRUE
ENST00000412277 ENSG00000185133 HEK293_OSMI2_6hA HEK293_TMG_6hB INPP5J protein_coding protein_coding 7.137841 10.06658 2.701806 1.083119 0.144865 -1.89368 0.49271277 0.85789435 0.1677143 0.27361233 0.07950929 -2.287960 0.07599167 0.086500000 0.06126667 -0.025233333 0.9021677396 0.0003531986 FALSE TRUE
ENST00000420017 ENSG00000185133 HEK293_OSMI2_6hA HEK293_TMG_6hB INPP5J protein_coding protein_coding 7.137841 10.06658 2.701806 1.083119 0.144865 -1.89368 0.01787553 0.00000000 0.1430042 0.00000000 0.14300420 3.935499 0.00738750 0.000000000 0.05910000 0.059100000 0.7124201428 0.0003531986 FALSE FALSE
ENST00000461241 ENSG00000185133 HEK293_OSMI2_6hA HEK293_TMG_6hB INPP5J protein_coding retained_intron 7.137841 10.06658 2.701806 1.083119 0.144865 -1.89368 0.45526440 0.61900814 0.2748927 0.27965553 0.06088141 -1.142660 0.08150417 0.066866667 0.10096667 0.034100000 0.7876106053 0.0003531986 FALSE TRUE
MSTRG.21953.1 ENSG00000185133 HEK293_OSMI2_6hA HEK293_TMG_6hB INPP5J protein_coding   7.137841 10.06658 2.701806 1.083119 0.144865 -1.89368 0.94673803 1.84359649 0.3189877 0.33965324 0.31898772 -2.494222 0.14883333 0.186600000 0.10993333 -0.076666667 0.5230018545 0.0003531986 FALSE TRUE
MSTRG.21953.9 ENSG00000185133 HEK293_OSMI2_6hA HEK293_TMG_6hB INPP5J protein_coding   7.137841 10.06658 2.701806 1.083119 0.144865 -1.89368 1.03422064 1.47136093 0.3858903 0.39891955 0.20573848 -1.903750 0.14044583 0.142933333 0.15126667 0.008333333 0.9583310032 0.0003531986 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000185133 E001 0.4458772 0.0217681645 0.4624732794   22 31112167 31112209 43 + 0.234 0.111 -1.296
ENSG00000185133 E002 0.0000000       22 31122731 31122790 60 +      
ENSG00000185133 E003 1.1713439 0.0204340117 0.4541588113   22 31122923 31122965 43 + 0.386 0.238 -0.971
ENSG00000185133 E004 2.5944953 0.0083549206 0.2084029662 0.439926126 22 31122966 31122974 9 + 0.234 0.503 1.610
ENSG00000185133 E005 6.3112029 0.0169904933 0.3160424623 0.556046769 22 31122975 31122983 9 + 0.871 0.719 -0.604
ENSG00000185133 E006 10.3337892 0.0041428825 0.6601389853 0.810061079 22 31122984 31122993 10 + 0.981 0.926 -0.208
ENSG00000185133 E007 26.8452741 0.0074060235 0.2697332690 0.509649747 22 31122994 31123119 126 + 1.224 1.332 0.379
ENSG00000185133 E008 2.8047007 0.5202709305 0.3477448085 0.585201587 22 31123896 31124005 110 + 0.664 0.443 -1.030
ENSG00000185133 E009 5.5136158 0.0708851374 0.4948775570 0.697341847 22 31124142 31124263 122 + 0.587 0.736 0.631
ENSG00000185133 E010 27.3065929 0.0130388012 0.1312271607 0.333733529 22 31124845 31124906 62 + 1.185 1.347 0.570
ENSG00000185133 E011 123.3759059 0.0003612242 0.9880389379 0.995832116 22 31124907 31125832 926 + 1.970 1.972 0.007
ENSG00000185133 E012 56.0435644 0.0007860599 0.3347870884 0.573378158 22 31125833 31126010 178 + 1.676 1.621 -0.189
ENSG00000185133 E013 2.0876764 0.1032564027 0.0321434530 0.133644206 22 31126294 31126375 82 + 0.724 0.305 -2.076
ENSG00000185133 E014 51.0116111 0.0010871874 0.1301234343 0.332030411 22 31126376 31126489 114 + 1.663 1.571 -0.313
ENSG00000185133 E015 50.8345120 0.0087272535 0.5037314610 0.703416836 22 31126613 31126721 109 + 1.628 1.576 -0.178
ENSG00000185133 E016 8.6670635 0.1456758758 0.3794912760 0.611799495 22 31126722 31126920 199 + 0.985 0.842 -0.543
ENSG00000185133 E017 24.2637418 0.0013917986 0.4655673493 0.677011408 22 31126921 31127037 117 + 1.223 1.293 0.244
ENSG00000185133 E018 7.6307244 0.0776611355 0.5208800472 0.715497907 22 31127038 31127356 319 + 0.913 0.805 -0.419
ENSG00000185133 E019 58.1294262 0.0009164509 0.0009339377 0.009369889 22 31127357 31127532 176 + 1.461 1.683 0.760
ENSG00000185133 E020 0.1426347 0.0316227718 0.0814307045   22 31127760 31127788 29 + 0.234 0.000 -12.525
ENSG00000185133 E021 0.1426347 0.0316227718 0.0814307045   22 31127789 31127801 13 + 0.234 0.000 -12.525
ENSG00000185133 E022 0.4458772 0.0217681645 0.4624732794   22 31127802 31127950 149 + 0.234 0.111 -1.296
ENSG00000185133 E023 46.5445399 0.0062138156 0.0826933751 0.250084358 22 31127951 31128062 112 + 1.438 1.581 0.488
ENSG00000185133 E024 0.0000000       22 31128063 31128213 151 +      
ENSG00000185133 E025 51.1884240 0.0013829193 0.8997006226 0.951728155 22 31128214 31128323 110 + 1.590 1.600 0.034
ENSG00000185133 E026 75.0948915 0.0006559763 0.0290579932 0.124532266 22 31128471 31128654 184 + 1.847 1.741 -0.358
ENSG00000185133 E027 60.9939357 0.0007394039 0.0040434961 0.029414377 22 31133098 31133235 138 + 1.791 1.637 -0.520
ENSG00000185133 E028 39.1246606 0.0010780696 0.4845618578 0.690236362 22 31133406 31133483 78 + 1.521 1.472 -0.166
ENSG00000185133 E029 53.7218690 0.0008366613 0.3376702659 0.576040119 22 31133610 31133714 105 + 1.565 1.628 0.213
ENSG00000185133 E030 2.3309214 0.0548064126 0.6975813394 0.833957676 22 31133715 31133912 198 + 0.498 0.417 -0.417
ENSG00000185133 E031 142.1105728 0.0029456179 0.0654975473 0.215020104 22 31133913 31134697 785 + 1.963 2.046 0.277