ENSG00000185090

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373045 ENSG00000185090 HEK293_OSMI2_6hA HEK293_TMG_6hB MANEAL protein_coding protein_coding 73.43256 93.50232 39.03061 13.05449 1.496034 -1.260181 10.71987 14.86577 3.653958 2.531007 0.4492917 -2.0214893 0.1473792 0.1573667 0.0932000 -0.06416667 0.0464024775 0.0001971056 FALSE TRUE
ENST00000397631 ENSG00000185090 HEK293_OSMI2_6hA HEK293_TMG_6hB MANEAL protein_coding protein_coding 73.43256 93.50232 39.03061 13.05449 1.496034 -1.260181 14.36553 16.51713 7.337937 2.459160 0.7701162 -1.1694254 0.1964917 0.1765333 0.1896333 0.01310000 0.9624661575 0.0001971056 FALSE TRUE
ENST00000525897 ENSG00000185090 HEK293_OSMI2_6hA HEK293_TMG_6hB MANEAL protein_coding protein_coding 73.43256 93.50232 39.03061 13.05449 1.496034 -1.260181 11.31363 13.87356 11.265220 1.396724 0.7645894 -0.3002217 0.1648958 0.1503333 0.2889000 0.13856667 0.0001971056 0.0001971056 FALSE TRUE
ENST00000532512 ENSG00000185090 HEK293_OSMI2_6hA HEK293_TMG_6hB MANEAL protein_coding protein_coding 73.43256 93.50232 39.03061 13.05449 1.496034 -1.260181 13.39848 19.79751 4.868855 2.836578 1.0669269 -2.0214326 0.1777250 0.2114667 0.1241667 -0.08730000 0.3082407972 0.0001971056 FALSE TRUE
MSTRG.872.3 ENSG00000185090 HEK293_OSMI2_6hA HEK293_TMG_6hB MANEAL protein_coding   73.43256 93.50232 39.03061 13.05449 1.496034 -1.260181 21.75779 26.29604 10.032380 4.616312 1.2719585 -1.3892931 0.2833917 0.2779333 0.2554000 -0.02253333 0.8900457241 0.0001971056 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000185090 E001 56.3851533 7.646472e-04 2.379111e-03 0.0195588774 1 37793847 37793882 36 + 1.507 1.706 0.677
ENSG00000185090 E002 162.1042901 2.126229e-01 5.102165e-02 0.1821153467 1 37793883 37794460 578 + 1.862 2.171 1.035
ENSG00000185090 E003 53.0923171 7.131257e-04 1.400938e-05 0.0002807878 1 37794461 37794482 22 + 1.392 1.695 1.037
ENSG00000185090 E004 358.5810969 3.244264e-01 2.065056e-01 0.4375306603 1 37794483 37794732 250 + 2.345 2.492 0.488
ENSG00000185090 E005 0.6072928 1.946814e-02 1.965706e-01   1 37795408 37795487 80 + 0.351 0.125 -1.900
ENSG00000185090 E006 0.7735102 2.308732e-02 3.235429e-01   1 37795488 37795632 145 + 0.352 0.176 -1.320
ENSG00000185090 E007 0.8738308 2.377664e-01 1.000000e+00   1 37795633 37795736 104 + 0.212 0.255 0.348
ENSG00000185090 E008 410.0527072 1.932170e-04 3.022421e-01 0.5428379334 1 37795737 37795846 110 + 2.535 2.524 -0.038
ENSG00000185090 E009 348.9951076 2.254156e-02 2.739831e-02 0.1194910884 1 37796744 37796820 77 + 2.529 2.431 -0.326
ENSG00000185090 E010 10.3571783 8.186284e-02 2.889749e-02 0.1240608464 1 37798289 37798398 110 + 1.204 0.885 -1.166
ENSG00000185090 E011 402.6981470 1.627274e-04 3.027158e-02 0.1281774030 1 37799567 37799843 277 + 2.547 2.511 -0.118
ENSG00000185090 E012 2400.2567290 8.302142e-05 1.286109e-01 0.3296469738 1 37799844 37801137 1294 + 3.292 3.293 0.003