ENSG00000185024

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327359 ENSG00000185024 HEK293_OSMI2_6hA HEK293_TMG_6hB BRF1 protein_coding protein_coding 29.90862 42.23054 17.06524 5.551047 0.538516 -1.306722 2.687785 2.450953 4.1019934 0.1753423 0.7564342 0.7406209 0.11097083 0.05983333 0.24036667 0.180533333 0.0009404471 0.0009404471 FALSE TRUE
ENST00000392557 ENSG00000185024 HEK293_OSMI2_6hA HEK293_TMG_6hB BRF1 protein_coding protein_coding 29.90862 42.23054 17.06524 5.551047 0.538516 -1.306722 3.289006 4.865549 2.1184217 0.5551303 0.4313392 -1.1957808 0.10977500 0.11736667 0.12363333 0.006266667 0.9973723251 0.0009404471 FALSE TRUE
ENST00000446501 ENSG00000185024 HEK293_OSMI2_6hA HEK293_TMG_6hB BRF1 protein_coding protein_coding 29.90862 42.23054 17.06524 5.551047 0.538516 -1.306722 10.351803 14.643450 3.7408896 2.9651605 0.5826581 -1.9659357 0.31358333 0.33970000 0.21910000 -0.120600000 0.3230483763 0.0009404471 FALSE TRUE
ENST00000547530 ENSG00000185024 HEK293_OSMI2_6hA HEK293_TMG_6hB BRF1 protein_coding protein_coding 29.90862 42.23054 17.06524 5.551047 0.538516 -1.306722 2.929590 5.021811 0.7342501 0.5809034 0.7342501 -2.7572184 0.09380417 0.11960000 0.04373333 -0.075866667 0.2955537623 0.0009404471 FALSE TRUE
MSTRG.10294.4 ENSG00000185024 HEK293_OSMI2_6hA HEK293_TMG_6hB BRF1 protein_coding   29.90862 42.23054 17.06524 5.551047 0.538516 -1.306722 2.772777 3.704508 1.5329158 1.0252760 0.7670438 -1.2675117 0.09557500 0.08410000 0.08943333 0.005333333 0.9532561010 0.0009404471 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000185024 E001 0.7198573 0.3538901308 4.152070e-01   14 105209286 105209288 3 - 0.000 0.255 11.057
ENSG00000185024 E002 99.9270399 0.4784587968 1.630368e-01 3.812627e-01 14 105209289 105209428 140 - 1.653 2.016 1.223
ENSG00000185024 E003 111.4164941 0.4958114221 1.486845e-01 3.603855e-01 14 105209429 105209495 67 - 1.677 2.066 1.310
ENSG00000185024 E004 221.1409642 1.0269045237 3.309392e-01 5.698367e-01 14 105209496 105209659 164 - 2.019 2.354 1.122
ENSG00000185024 E005 360.9272377 1.2166479572 3.559804e-01 5.924993e-01 14 105209660 105210077 418 - 2.227 2.567 1.132
ENSG00000185024 E006 266.4060261 1.1703670877 4.383039e-01 6.574578e-01 14 105210078 105210277 200 - 2.176 2.421 0.818
ENSG00000185024 E007 196.4123739 1.0689876721 4.506752e-01 6.661522e-01 14 105210278 105210366 89 - 2.064 2.285 0.738
ENSG00000185024 E008 301.5256394 1.2179909856 4.457440e-01 6.625732e-01 14 105210367 105210588 222 - 2.229 2.475 0.821
ENSG00000185024 E009 302.4237166 0.0006271942 1.314464e-01 3.340761e-01 14 105211122 105211293 172 - 2.343 2.458 0.382
ENSG00000185024 E010 33.3161611 0.0944615829 8.916730e-01 9.474666e-01 14 105211294 105212112 819 - 1.401 1.506 0.363
ENSG00000185024 E011 202.5763388 0.0029009522 4.329567e-01 6.534392e-01 14 105212113 105212164 52 - 2.218 2.267 0.164
ENSG00000185024 E012 5.2413534 0.0058910766 2.721290e-01 5.119957e-01 14 105212165 105213428 1264 - 0.568 0.805 0.996
ENSG00000185024 E013 1.9107223 0.0107874066 1.854251e-01 4.111217e-01 14 105217213 105217278 66 - 0.188 0.494 1.971
ENSG00000185024 E014 212.2920382 0.0075074987 9.837609e-01 9.937056e-01 14 105217544 105217632 89 - 2.213 2.292 0.265
ENSG00000185024 E015 286.5200442 0.0233014342 8.889744e-01 9.461553e-01 14 105217633 105217800 168 - 2.353 2.417 0.214
ENSG00000185024 E016 181.2752151 0.0194054173 4.453555e-01 6.623429e-01 14 105218998 105219053 56 - 2.190 2.208 0.062
ENSG00000185024 E017 205.0140629 0.0164282730 4.655818e-01 6.770132e-01 14 105219151 105219232 82 - 2.238 2.263 0.084
ENSG00000185024 E018 9.5872915 0.0035632685 5.054547e-01 7.045988e-01 14 105219233 105219298 66 - 0.984 0.976 -0.031
ENSG00000185024 E019 21.1723807 0.0663413957 6.218686e-01 7.850578e-01 14 105219299 105220068 770 - 1.286 1.294 0.028
ENSG00000185024 E020 162.2176157 0.0011229418 5.859859e-01 7.609375e-01 14 105220069 105220127 59 - 2.116 2.172 0.187
ENSG00000185024 E021 73.8101563 0.0005099018 4.542002e-01 6.688952e-01 14 105220128 105220130 3 - 1.793 1.832 0.134
ENSG00000185024 E022 249.1352613 0.0024320653 3.192293e-03 2.456054e-02 14 105221648 105221884 237 - 2.362 2.338 -0.080
ENSG00000185024 E023 97.0299947 0.0009260539 1.875943e-03 1.623577e-02 14 105221885 105221914 30 - 1.980 1.926 -0.181
ENSG00000185024 E024 16.0170545 0.0497236774 1.890764e-01 4.158109e-01 14 105221915 105222545 631 - 1.259 1.140 -0.422
ENSG00000185024 E025 90.9275736 0.0004431269 5.223280e-03 3.579489e-02 14 105226069 105226102 34 - 1.942 1.901 -0.138
ENSG00000185024 E026 68.0373880 0.0006888630 4.935379e-03 3.428540e-02 14 105226103 105226113 11 - 1.829 1.768 -0.206
ENSG00000185024 E027 67.1910335 0.0008925315 1.083268e-03 1.055197e-02 14 105226114 105226122 9 - 1.839 1.755 -0.285
ENSG00000185024 E028 95.8743421 0.0022880687 8.065768e-05 1.250003e-03 14 105226123 105226161 39 - 2.006 1.902 -0.350
ENSG00000185024 E029 99.6804991 0.0005049334 2.015091e-06 5.256664e-05 14 105226251 105226290 40 - 2.029 1.917 -0.375
ENSG00000185024 E030 175.8457378 0.0007056792 9.067048e-06 1.928357e-04 14 105226634 105226760 127 - 2.242 2.178 -0.213
ENSG00000185024 E031 15.2442275 0.0150219058 7.002806e-01 8.358337e-01 14 105226761 105228270 1510 - 1.144 1.170 0.092
ENSG00000185024 E032 99.3268458 0.0008427907 1.758834e-03 1.542531e-02 14 105228820 105228860 41 - 1.988 1.935 -0.176
ENSG00000185024 E033 106.0818269 0.0005643195 1.547846e-02 7.987606e-02 14 105228861 105228913 53 - 1.992 1.973 -0.066
ENSG00000185024 E034 67.4678585 0.0008418251 5.690185e-03 3.818973e-02 14 105241265 105241304 40 - 1.825 1.765 -0.204
ENSG00000185024 E035 101.0402447 0.0143822665 1.546885e-02 7.985286e-02 14 105241305 105241414 110 - 2.019 1.926 -0.311
ENSG00000185024 E036 3.6242000 0.0088337907 9.700775e-01 9.868997e-01 14 105241415 105242605 1191 - 0.568 0.631 0.279
ENSG00000185024 E037 42.1617378 0.0060429419 6.814946e-01 8.235968e-01 14 105247071 105247287 217 - 1.502 1.605 0.353
ENSG00000185024 E038 104.9244673 0.0218721965 2.628766e-01 5.021031e-01 14 105247288 105248074 787 - 1.980 1.963 -0.058
ENSG00000185024 E039 44.9870970 0.0011735515 7.255455e-01 8.514686e-01 14 105248075 105249148 1074 - 1.538 1.635 0.331
ENSG00000185024 E040 7.6697557 0.0091691986 7.549472e-01 8.696428e-01 14 105249149 105249404 256 - 0.806 0.911 0.404
ENSG00000185024 E041 53.6250498 0.0158545787 1.695520e-03 1.498945e-02 14 105252507 105252514 8 - 1.802 1.634 -0.568
ENSG00000185024 E042 80.3730982 0.0334162212 2.843182e-02 1.225974e-01 14 105252515 105252579 65 - 1.954 1.813 -0.476
ENSG00000185024 E043 24.6767805 0.0819472268 6.187681e-01 7.830098e-01 14 105256186 105256517 332 - 1.210 1.397 0.653
ENSG00000185024 E044 86.9049356 0.0272721486 2.098230e-01 4.416391e-01 14 105256518 105256549 32 - 1.911 1.880 -0.104
ENSG00000185024 E045 142.1608734 0.0177539224 7.897594e-02 2.427894e-01 14 105272721 105272894 174 - 2.128 2.089 -0.129
ENSG00000185024 E046 77.0374641 0.0200075973 3.637357e-01 5.988375e-01 14 105286296 105286376 81 - 1.827 1.839 0.040
ENSG00000185024 E047 82.1991980 0.0007028492 5.293986e-01 7.216109e-01 14 105300446 105301278 833 - 1.789 1.895 0.357
ENSG00000185024 E048 0.5363366 0.0526300711 5.007639e-01   14 105315322 105315341 20 - 0.000 0.199 10.544
ENSG00000185024 E049 1.2018237 0.0136968632 8.509081e-02   14 105315342 105315589 248 - 0.000 0.404 11.948