ENSG00000185008

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332191 ENSG00000185008 HEK293_OSMI2_6hA HEK293_TMG_6hB ROBO2 protein_coding protein_coding 1.65671 1.003007 2.177008 0.3242963 0.1668948 1.110315 0.11039898 0.08947130 0.3170087 0.04487219 0.05514030 1.7169768 0.06164167 0.07123333 0.1439667 0.07273333 0.75849001 0.04353873 FALSE TRUE
ENST00000461745 ENSG00000185008 HEK293_OSMI2_6hA HEK293_TMG_6hB ROBO2 protein_coding protein_coding 1.65671 1.003007 2.177008 0.3242963 0.1668948 1.110315 0.06598615 0.09760410 0.1097650 0.02544836 0.06731166 0.1544728 0.04303750 0.15426667 0.0560000 -0.09826667 0.74604151 0.04353873 FALSE TRUE
ENST00000490991 ENSG00000185008 HEK293_OSMI2_6hA HEK293_TMG_6hB ROBO2 protein_coding protein_coding 1.65671 1.003007 2.177008 0.3242963 0.1668948 1.110315 0.40643063 0.39266244 0.2806231 0.15769724 0.07158254 -0.4704217 0.28243750 0.36656667 0.1258000 -0.24076667 0.04353873 0.04353873 FALSE TRUE
ENST00000602589 ENSG00000185008 HEK293_OSMI2_6hA HEK293_TMG_6hB ROBO2 protein_coding protein_coding 1.65671 1.003007 2.177008 0.3242963 0.1668948 1.110315 0.46736636 0.08640178 0.7094897 0.08640178 0.17098890 2.8998423 0.22308333 0.05686667 0.3171333 0.26026667 0.20219844 0.04353873 FALSE TRUE
ENST00000696593 ENSG00000185008 HEK293_OSMI2_6hA HEK293_TMG_6hB ROBO2 protein_coding protein_coding 1.65671 1.003007 2.177008 0.3242963 0.1668948 1.110315 0.52091597 0.28387445 0.6577700 0.08253437 0.08184789 1.1841514 0.32797500 0.29483333 0.3120333 0.01720000 0.99775070 0.04353873 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000185008 E001 0.0000000       3 75906695 75906704 10 +      
ENSG00000185008 E002 0.0000000       3 75906705 75906801 97 +      
ENSG00000185008 E003 0.2027342 0.033253283 0.237698393   3 75906802 75906960 159 + 0.000 0.165 10.045
ENSG00000185008 E004 0.0000000       3 75937481 75937602 122 +      
ENSG00000185008 E005 0.0000000       3 76311096 76311417 322 +      
ENSG00000185008 E006 0.9762444 0.015722357 0.099695765   3 77039886 77040098 213 + 0.162 0.454 2.034
ENSG00000185008 E007 1.2687159 0.181174677 0.382927993   3 77040099 77040146 48 + 0.281 0.451 1.006
ENSG00000185008 E008 14.9951933 0.197098487 0.765050012 0.87566953 3 77040147 77040675 529 + 1.167 1.203 0.127
ENSG00000185008 E009 5.6588346 0.036556798 0.161120126 0.37847626 3 77040676 77040729 54 + 0.725 0.941 0.845
ENSG00000185008 E010 11.1284870 0.012063907 0.351367113 0.58852172 3 77040730 77040846 117 + 1.021 1.128 0.388
ENSG00000185008 E011 18.3678338 0.002002107 0.660134702 0.81006108 3 77098014 77098340 327 + 1.274 1.246 -0.099
ENSG00000185008 E012 13.0246934 0.002765478 0.031885850 0.13286863 3 77477414 77477571 158 + 1.182 0.969 -0.773
ENSG00000185008 E013 11.3014726 0.003250037 0.210251985 0.44212335 3 77481099 77481219 121 + 1.112 0.990 -0.446
ENSG00000185008 E014 12.6597905 0.002587708 0.392255514 0.62219449 3 77493244 77493382 139 + 1.141 1.065 -0.274
ENSG00000185008 E015 9.7285500 0.003613771 0.275932977 0.51600543 3 77522775 77522902 128 + 1.038 0.924 -0.424
ENSG00000185008 E016 4.5482782 0.010176236 0.593463056 0.76597628 3 77527403 77527414 12 + 0.742 0.671 -0.290
ENSG00000185008 E017 9.7840498 0.016230775 0.750935514 0.86733583 3 77546338 77546462 125 + 1.020 0.989 -0.113
ENSG00000185008 E018 13.0388962 0.058353344 0.792105520 0.89166962 3 77550818 77550989 172 + 1.109 1.147 0.136
ENSG00000185008 E019 13.3980038 0.002813749 0.665065573 0.81310424 3 77557944 77558149 206 + 1.148 1.114 -0.121
ENSG00000185008 E020 7.0961416 0.004684375 0.536777599 0.72688155 3 77562651 77562732 82 + 0.914 0.845 -0.266
ENSG00000185008 E021 4.2450333 0.006609719 0.700084868 0.83569168 3 77563167 77563179 13 + 0.723 0.671 -0.212
ENSG00000185008 E022 6.9694396 0.004175878 0.298646937 0.53909648 3 77563180 77563329 150 + 0.836 0.969 0.504
ENSG00000185008 E023 0.1779838 0.037731870 1.000000000   3 77564450 77564588 139 + 0.088 0.000 -11.378
ENSG00000185008 E024 8.3749321 0.076089844 0.292068508 0.53275422 3 77564954 77565120 167 + 0.885 1.074 0.701
ENSG00000185008 E025 6.9135123 0.308329338 0.535335268 0.72582885 3 77568313 77568434 122 + 0.853 0.924 0.270
ENSG00000185008 E026 10.7043824 0.003413359 0.174582792 0.39660292 3 77574499 77574730 232 + 1.088 0.947 -0.520
ENSG00000185008 E027 10.4185682 0.040523367 0.091463835 0.26639448 3 77577490 77577614 125 + 1.094 0.853 -0.900
ENSG00000185008 E028 12.0534592 0.022139763 0.270821571 0.51074669 3 77579947 77580118 172 + 1.126 0.994 -0.479
ENSG00000185008 E029 9.0120479 0.068019326 0.353411812 0.59034169 3 77588751 77588780 30 + 1.015 0.854 -0.606
ENSG00000185008 E030 13.1177263 0.002744690 0.486258278 0.69142718 3 77588781 77588933 153 + 1.141 1.082 -0.213
ENSG00000185008 E031 9.1275864 0.003944556 0.649166061 0.80294331 3 77595142 77595184 43 + 0.991 0.947 -0.161
ENSG00000185008 E032 10.8041401 0.003169464 0.871584835 0.93682254 3 77596623 77596750 128 + 1.055 1.048 -0.028
ENSG00000185008 E033 16.8043346 0.030616934 0.988584150 0.99606118 3 77602210 77602482 273 + 1.216 1.230 0.048
ENSG00000185008 E034 3.9837589 0.051813243 0.229709683 0.46481409 3 77602483 77602491 9 + 0.593 0.790 0.824
ENSG00000185008 E035 0.0000000       3 77602935 77603060 126 +      
ENSG00000185008 E036 0.0000000       3 77603744 77603951 208 +      
ENSG00000185008 E037 0.0000000       3 77603952 77604041 90 +      
ENSG00000185008 E038 12.9944182 0.024403476 0.079174621 0.24318193 3 77607798 77607954 157 + 1.037 1.240 0.729
ENSG00000185008 E039 15.6954856 0.002826888 0.754942228 0.86964278 3 77617513 77617773 261 + 1.188 1.223 0.125
ENSG00000185008 E040 3.3811999 0.006893305 0.002204173 0.01843193 3 77617774 77618180 407 + 0.411 0.873 2.036
ENSG00000185008 E041 9.7166094 0.003382448 0.725195325 0.85125149 3 77622227 77622432 206 + 1.020 0.990 -0.110
ENSG00000185008 E042 0.4654660 0.027151195 0.271766827   3 77629122 77632473 3352 + 0.224 0.000 -12.864
ENSG00000185008 E043 3.3530913 0.007476588 0.350891885 0.58808535 3 77632474 77632656 183 + 0.663 0.520 -0.643
ENSG00000185008 E044 0.3393995 0.027442404 0.490498975   3 77632657 77634869 2213 + 0.162 0.000 -12.325
ENSG00000185008 E045 9.4699524 0.003418498 0.997726481 1.00000000 3 77634870 77635043 174 + 1.000 1.010 0.035
ENSG00000185008 E046 4.9638975 0.007957132 0.267104779 0.50672537 3 77642671 77642943 273 + 0.685 0.846 0.647
ENSG00000185008 E047 10.3454443 0.004043688 0.395676840 0.62498282 3 77644704 77644895 192 + 1.001 1.098 0.356
ENSG00000185008 E048 3.0918508 0.084226346 0.987426327 0.99555146 3 77644896 77644904 9 + 0.595 0.619 0.103
ENSG00000185008 E049 59.3282813 0.016339416 0.499086369 0.70016154 3 77646054 77649964 3911 + 1.734 1.795 0.205