ENSG00000184939

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398253 ENSG00000184939 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFP90 protein_coding protein_coding 5.740211 3.893451 5.920743 0.9515309 0.2401971 0.6034626 0.2315067 0.00000000 0.89133110 0.00000000 0.89133110 6.4939853 0.03644167 0.00000000 0.140333333 0.140333333 0.93450551 0.01000986 FALSE TRUE
ENST00000563169 ENSG00000184939 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFP90 protein_coding protein_coding 5.740211 3.893451 5.920743 0.9515309 0.2401971 0.6034626 0.4321568 0.00000000 0.84436410 0.00000000 0.43845602 6.4167791 0.07165417 0.00000000 0.147366667 0.147366667 0.36871221 0.01000986 FALSE TRUE
ENST00000564323 ENSG00000184939 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFP90 protein_coding protein_coding 5.740211 3.893451 5.920743 0.9515309 0.2401971 0.6034626 0.5007036 0.35630196 0.21101676 0.18289264 0.21101676 -0.7288777 0.09935833 0.08470000 0.035833333 -0.048866667 0.69713796 0.01000986 FALSE TRUE
ENST00000564558 ENSG00000184939 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFP90 protein_coding nonsense_mediated_decay 5.740211 3.893451 5.920743 0.9515309 0.2401971 0.6034626 0.1049738 0.33892514 0.03203207 0.17614921 0.03203207 -3.0533551 0.02304583 0.11436667 0.005433333 -0.108933333 0.55521085 0.01000986 FALSE TRUE
ENST00000569323 ENSG00000184939 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFP90 protein_coding nonsense_mediated_decay 5.740211 3.893451 5.920743 0.9515309 0.2401971 0.6034626 0.3667838 0.17272952 0.68901652 0.17272952 0.37418751 1.9356168 0.05772500 0.02983333 0.120733333 0.090900000 0.53504035 0.01000986 FALSE TRUE
ENST00000570495 ENSG00000184939 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFP90 protein_coding protein_coding 5.740211 3.893451 5.920743 0.9515309 0.2401971 0.6034626 0.2362614 0.36260867 0.00000000 0.36260867 0.00000000 -5.2195893 0.04344583 0.12976667 0.000000000 -0.129766667 0.88646771 0.01000986 FALSE TRUE
ENST00000571720 ENSG00000184939 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFP90 protein_coding retained_intron 5.740211 3.893451 5.920743 0.9515309 0.2401971 0.6034626 0.3613658 0.04401346 0.54890348 0.04401346 0.15521357 3.3712083 0.05370833 0.00760000 0.091100000 0.083500000 0.03993199 0.01000986 FALSE TRUE
ENST00000573161 ENSG00000184939 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFP90 protein_coding protein_coding 5.740211 3.893451 5.920743 0.9515309 0.2401971 0.6034626 0.2653699 0.77747627 0.00000000 0.77747627 0.00000000 -6.2991646 0.05011250 0.13430000 0.000000000 -0.134300000 0.81341160 0.01000986   FALSE
ENST00000573685 ENSG00000184939 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFP90 protein_coding protein_coding 5.740211 3.893451 5.920743 0.9515309 0.2401971 0.6034626 0.3683360 0.39483525 0.18347119 0.19866551 0.09465669 -1.0652161 0.06257917 0.09976667 0.031400000 -0.068366667 0.83839902 0.01000986 FALSE TRUE
ENST00000576305 ENSG00000184939 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFP90 protein_coding protein_coding 5.740211 3.893451 5.920743 0.9515309 0.2401971 0.6034626 0.1760004 0.29437558 0.04577085 0.22238314 0.04577085 -2.4482695 0.02872917 0.06030000 0.007766667 -0.052533333 0.62875019 0.01000986 FALSE FALSE
ENST00000611381 ENSG00000184939 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFP90 protein_coding protein_coding 5.740211 3.893451 5.920743 0.9515309 0.2401971 0.6034626 0.3817623 0.24368143 0.41534450 0.07131400 0.13489040 0.7456139 0.07337500 0.06770000 0.070366667 0.002666667 1.00000000 0.01000986 FALSE FALSE
MSTRG.12869.16 ENSG00000184939 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFP90 protein_coding   5.740211 3.893451 5.920743 0.9515309 0.2401971 0.6034626 0.6729483 0.67395512 0.14218949 0.07430610 0.14218949 -2.1680330 0.14762917 0.20003333 0.024133333 -0.175900000 0.16907977 0.01000986   FALSE
MSTRG.12869.3 ENSG00000184939 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFP90 protein_coding   5.740211 3.893451 5.920743 0.9515309 0.2401971 0.6034626 1.1480370 0.18831912 1.64773995 0.02750233 0.34332636 3.0633221 0.17293333 0.05666667 0.279166667 0.222500000 0.01000986 0.01000986 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000184939 E001 0.1308682 0.034797777 0.363212413   16 68530090 68530117 28 + 0.000 0.121 30.668
ENSG00000184939 E002 2.5814771 0.143868520 0.642137605 0.79824746 16 68530118 68530147 30 + 0.626 0.470 -0.726
ENSG00000184939 E003 5.1613615 0.201298710 0.440135237 0.65883145 16 68530148 68530283 136 + 0.889 0.663 -0.903
ENSG00000184939 E004 4.7703049 0.068805495 0.154539793 0.36879904 16 68530284 68530334 51 + 0.906 0.555 -1.445
ENSG00000184939 E005 0.1308682 0.034797777 0.363212413   16 68530335 68530534 200 + 0.000 0.121 30.671
ENSG00000184939 E006 7.7655756 0.008059570 0.155938033 0.37081137 16 68533698 68533855 158 + 1.077 0.767 -1.177
ENSG00000184939 E007 0.0000000       16 68539213 68539290 78 +      
ENSG00000184939 E008 0.0000000       16 68539291 68539296 6 +      
ENSG00000184939 E009 2.9120298 0.102520651 0.018469766 0.09060301 16 68539297 68539313 17 + 0.359 0.723 1.736
ENSG00000184939 E010 3.5073685 0.107430812 0.004873656 0.03394131 16 68539314 68539315 2 + 0.359 0.816 2.108
ENSG00000184939 E011 5.5474341 0.122431440 0.018920454 0.09216971 16 68539316 68539322 7 + 0.590 0.952 1.460
ENSG00000184939 E012 5.8091704 0.112078725 0.010127900 0.05868538 16 68539323 68539324 2 + 0.590 0.979 1.561
ENSG00000184939 E013 8.8905374 0.014613043 0.002558100 0.02071054 16 68539325 68539378 54 + 0.871 1.090 0.812
ENSG00000184939 E014 11.2565182 0.042409267 0.013150970 0.07105072 16 68539379 68539429 51 + 0.971 1.181 0.763
ENSG00000184939 E015 10.7449320 0.012688454 0.001757584 0.01541965 16 68539430 68539469 40 + 0.957 1.163 0.750
ENSG00000184939 E016 4.7766161 0.039876470 0.121497039 0.31825278 16 68539470 68539479 10 + 0.714 0.829 0.461
ENSG00000184939 E017 3.0983447 0.015767982 0.013607061 0.07281066 16 68539480 68539487 8 + 0.468 0.740 1.217
ENSG00000184939 E018 1.4616026 0.325661709 0.727638409 0.85281755 16 68539703 68539757 55 + 0.360 0.419 0.329
ENSG00000184939 E019 12.6184498 0.077893553 0.012861276 0.06987260 16 68539758 68539794 37 + 0.970 1.248 1.006
ENSG00000184939 E020 11.3319840 0.113052243 0.363599299 0.59869730 16 68539795 68539825 31 + 1.055 1.123 0.247
ENSG00000184939 E021 2.7773461 0.136193836 0.008900547 0.05337280 16 68555073 68555240 168 + 0.291 0.747 2.261
ENSG00000184939 E022 0.1614157 0.032515179 0.647635679   16 68557173 68557291 119 + 0.121 0.000 -30.712
ENSG00000184939 E023 8.7424350 0.106123853 0.253795145 0.49215809 16 68557998 68558004 7 + 1.115 0.811 -1.137
ENSG00000184939 E024 11.1929992 0.096479887 0.162523688 0.38052117 16 68558005 68558039 35 + 1.226 0.887 -1.239
ENSG00000184939 E025 17.1904666 0.113325973 0.069704733 0.22418596 16 68558040 68558124 85 + 1.424 1.001 -1.500
ENSG00000184939 E026 0.3206185 0.028988803 0.313963958   16 68558125 68558172 48 + 0.216 0.000 -31.712
ENSG00000184939 E027 3.1049521 0.424411415 0.952173419 0.97804964 16 68558375 68558472 98 + 0.672 0.544 -0.566
ENSG00000184939 E028 22.0625355 0.108536979 0.016394900 0.08325303 16 68558473 68558568 96 + 1.550 1.040 -1.794
ENSG00000184939 E029 6.4539427 0.263799805 0.012498676 0.06842782 16 68562061 68562988 928 + 1.091 0.423 -2.777
ENSG00000184939 E030 1.7170165 0.012198908 0.001506794 0.01366559 16 68562989 68563043 55 + 0.658 0.000 -34.170
ENSG00000184939 E031 275.8326101 0.394613869 0.893935371 0.94867809 16 68563044 68567136 4093 + 2.531 2.334 -0.657
ENSG00000184939 E032 2.9045304 0.008355397 0.032096211 0.13349681 16 68575791 68576072 282 + 0.468 0.687 0.998