ENSG00000184937

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332351 ENSG00000184937 HEK293_OSMI2_6hA HEK293_TMG_6hB WT1 protein_coding protein_coding 2.48791 2.950198 2.246676 0.1995723 0.2062292 -0.3914942 0.62830403 0.7577871 0.0000000 0.06630283 0.00000000 -6.2626345 0.244395833 0.25993333 0.00000000 -0.25993333 2.408696e-08 2.408696e-08 FALSE TRUE
ENST00000379079 ENSG00000184937 HEK293_OSMI2_6hA HEK293_TMG_6hB WT1 protein_coding protein_coding 2.48791 2.950198 2.246676 0.1995723 0.2062292 -0.3914942 0.20053782 0.1958313 0.3451951 0.19583132 0.17792690 0.7871491 0.076370833 0.06433333 0.15146667 0.08713333 7.160621e-01 2.408696e-08 FALSE TRUE
ENST00000452863 ENSG00000184937 HEK293_OSMI2_6hA HEK293_TMG_6hB WT1 protein_coding protein_coding 2.48791 2.950198 2.246676 0.1995723 0.2062292 -0.3914942 0.29212551 0.3622849 0.1490377 0.19925883 0.14903766 -1.2270386 0.136745833 0.13036667 0.06853333 -0.06183333 7.871469e-01 2.408696e-08 FALSE TRUE
ENST00000639563 ENSG00000184937 HEK293_OSMI2_6hA HEK293_TMG_6hB WT1 protein_coding protein_coding 2.48791 2.950198 2.246676 0.1995723 0.2062292 -0.3914942 0.10115158 0.2575568 0.4504918 0.25755683 0.09499926 0.7833301 0.043566667 0.08463333 0.19763333 0.11300000 4.139447e-01 2.408696e-08 FALSE TRUE
ENST00000639907 ENSG00000184937 HEK293_OSMI2_6hA HEK293_TMG_6hB WT1 protein_coding retained_intron 2.48791 2.950198 2.246676 0.1995723 0.2062292 -0.3914942 0.01918183 0.0000000 0.1534546 0.00000000 0.15345460 4.0308181 0.007279167 0.00000000 0.05823333 0.05823333 8.095227e-01 2.408696e-08 FALSE TRUE
ENST00000640146 ENSG00000184937 HEK293_OSMI2_6hA HEK293_TMG_6hB WT1 protein_coding protein_coding 2.48791 2.950198 2.246676 0.1995723 0.2062292 -0.3914942 0.03789582 0.0000000 0.1486049 0.00000000 0.14860493 3.9873657 0.023850000 0.00000000 0.07696667 0.07696667 8.491063e-01 2.408696e-08 FALSE TRUE
ENST00000651668 ENSG00000184937 HEK293_OSMI2_6hA HEK293_TMG_6hB WT1 protein_coding processed_transcript 2.48791 2.950198 2.246676 0.1995723 0.2062292 -0.3914942 0.05273280 0.0000000 0.2531749 0.00000000 0.25317489 4.7179500 0.024091667 0.00000000 0.13110000 0.13110000 8.656808e-01 2.408696e-08 FALSE FALSE
ENST00000651819 ENSG00000184937 HEK293_OSMI2_6hA HEK293_TMG_6hB WT1 protein_coding retained_intron 2.48791 2.950198 2.246676 0.1995723 0.2062292 -0.3914942 0.77072524 0.7794695 0.3836609 0.18216070 0.38366089 -1.0039302 0.286879167 0.27503333 0.17643333 -0.09860000 5.314424e-01 2.408696e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000184937 E001 0.4880035 0.106964981 0.26162995   11 32387775 32387777 3 - 0.284 0.088 -2.034
ENSG00000184937 E002 0.4880035 0.106964981 0.26162995   11 32387778 32387783 6 - 0.284 0.088 -2.034
ENSG00000184937 E003 3.9531436 0.007077396 0.69665443 0.83342638 11 32387784 32387901 118 - 0.715 0.661 -0.225
ENSG00000184937 E004 6.4454129 0.005130403 0.28074277 0.52099288 11 32387902 32388022 121 - 0.752 0.899 0.575
ENSG00000184937 E005 8.0939216 0.011167451 0.29122223 0.53179869 11 32388023 32388129 107 - 0.847 0.986 0.524
ENSG00000184937 E006 5.0527413 0.024889533 0.59668275 0.76808981 11 32388130 32388130 1 - 0.714 0.800 0.348
ENSG00000184937 E007 5.0527413 0.024889533 0.59668275 0.76808981 11 32388131 32388131 1 - 0.714 0.800 0.348
ENSG00000184937 E008 8.2656261 0.054072716 0.58462655 0.76008386 11 32388132 32388160 29 - 0.897 0.973 0.286
ENSG00000184937 E009 14.2567398 0.003298910 0.96071114 0.98225559 11 32388161 32388311 151 - 1.161 1.159 -0.005
ENSG00000184937 E010 28.2577176 0.001666844 0.64465983 0.79994495 11 32388312 32388678 367 - 1.454 1.427 -0.092
ENSG00000184937 E011 28.9422611 0.017099763 0.57682697 0.75501362 11 32388679 32389041 363 - 1.476 1.439 -0.128
ENSG00000184937 E012 8.8633971 0.003797962 0.04534917 0.16845933 11 32389042 32389056 15 - 0.786 1.035 0.944
ENSG00000184937 E013 7.6025714 0.004665076 0.21871487 0.45185907 11 32389057 32389057 1 - 0.786 0.947 0.617
ENSG00000184937 E014 12.3462210 0.004766969 0.75488539 0.86961499 11 32389058 32389091 34 - 1.068 1.103 0.127
ENSG00000184937 E015 15.1423057 0.002456506 0.87204867 0.93703049 11 32389092 32389179 88 - 1.161 1.179 0.066
ENSG00000184937 E016 4.5575332 0.005762636 0.99072285 0.99708738 11 32391972 32391980 9 - 0.715 0.720 0.022
ENSG00000184937 E017 14.7271113 0.002612725 0.65969594 0.80979829 11 32391981 32392064 84 - 1.188 1.153 -0.126
ENSG00000184937 E018 0.1308682 0.032649190 1.00000000   11 32392065 32392081 17 - 0.000 0.088 11.238
ENSG00000184937 E019 0.6597577 0.619522318 1.00000000   11 32392082 32392665 584 - 0.163 0.228 0.598
ENSG00000184937 E020 13.3669087 0.003094416 0.11284973 0.30393301 11 32392666 32392755 90 - 1.214 1.070 -0.514
ENSG00000184937 E021 0.0000000       11 32392756 32393065 310 -      
ENSG00000184937 E022 0.1426347 0.030899695 0.23310427   11 32393066 32393228 163 - 0.166 0.000 -13.577
ENSG00000184937 E023 0.5474829 0.095427189 0.28304142   11 32396157 32396256 100 - 0.000 0.225 12.706
ENSG00000184937 E024 13.2039389 0.036928474 0.63751329 0.79541855 11 32396257 32396365 109 - 1.149 1.108 -0.148
ENSG00000184937 E025 8.8378300 0.003726079 0.11584667 0.30890513 11 32396366 32396407 42 - 1.068 0.900 -0.625
ENSG00000184937 E026 0.0000000       11 32396408 32396445 38 -      
ENSG00000184937 E027 0.1779838 0.033485856 0.23221874   11 32396446 32396982 537 - 0.166 0.000 -13.577
ENSG00000184937 E028 0.0000000       11 32396983 32397032 50 -      
ENSG00000184937 E029 1.1956618 1.110820027 0.95094133   11 32397033 32398101 1069 - 0.167 0.381 1.587
ENSG00000184937 E030 9.4488658 0.009231736 0.13666424 0.34240258 11 32399948 32399982 35 - 1.085 0.925 -0.593
ENSG00000184937 E031 12.1415366 0.003711872 0.40102105 0.62911749 11 32399983 32400044 62 - 1.132 1.054 -0.285
ENSG00000184937 E032 0.1308682 0.032649190 1.00000000   11 32400045 32400145 101 - 0.000 0.088 11.238
ENSG00000184937 E033 0.0000000       11 32400146 32400203 58 -      
ENSG00000184937 E034 0.1308682 0.032649190 1.00000000   11 32400204 32400351 148 - 0.000 0.088 11.238
ENSG00000184937 E035 0.1308682 0.032649190 1.00000000   11 32400352 32400615 264 - 0.000 0.088 11.238
ENSG00000184937 E036 0.0000000       11 32412089 32412264 176 -      
ENSG00000184937 E037 3.2011207 0.009184876 0.95300039 0.97845263 11 32416490 32416540 51 - 0.579 0.592 0.060
ENSG00000184937 E038 0.0000000       11 32416541 32417248 708 -      
ENSG00000184937 E039 0.0000000       11 32417424 32417576 153 -      
ENSG00000184937 E040 7.6697923 0.042056726 0.39887518 0.62730596 11 32417577 32417597 21 - 0.974 0.855 -0.449
ENSG00000184937 E041 9.9121484 0.006062517 0.60363624 0.77259743 11 32417598 32417654 57 - 1.032 0.979 -0.195
ENSG00000184937 E042 12.3531205 0.002951920 0.76754667 0.87714970 11 32427956 32428058 103 - 1.068 1.102 0.123
ENSG00000184937 E043 11.5215495 0.003137399 0.62134034 0.78477045 11 32428497 32428619 123 - 1.032 1.086 0.198
ENSG00000184937 E044 0.0000000       11 32428946 32429029 84 -      
ENSG00000184937 E045 0.0000000       11 32430530 32430813 284 -      
ENSG00000184937 E046 0.0000000       11 32433936 32434168 233 -      
ENSG00000184937 E047 13.8221522 0.017515417 0.15925471 0.37563178 11 32434700 32435360 661 - 1.030 1.187 0.569
ENSG00000184937 E048 1.6184385 0.012353490 0.01058152 0.06059025 11 32435361 32435535 175 - 0.000 0.510 14.305
ENSG00000184937 E049 0.0000000       11 32435536 32435539 4 -      
ENSG00000184937 E050 0.0000000       11 32435540 32435541 2 -      
ENSG00000184937 E051 0.0000000       11 32435542 32435564 23 -