ENSG00000184863

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000287912 ENSG00000184863 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM33 protein_coding protein_coding 16.28547 19.73519 19.52752 0.1693314 1.090841 -0.01525429 1.0715931 0.4338636 1.225261 0.24574607 0.08822847 1.47662715 0.06767917 0.02213333 0.06316667 0.04103333 5.181131e-01 7.068671e-18 FALSE TRUE
ENST00000341148 ENSG00000184863 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM33 protein_coding protein_coding 16.28547 19.73519 19.52752 0.1693314 1.090841 -0.01525429 1.8201832 3.9360684 0.000000 0.64131405 0.00000000 -8.62427216 0.11808333 0.19910000 0.00000000 -0.19910000 7.068671e-18 7.068671e-18 FALSE FALSE
ENST00000392755 ENSG00000184863 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM33 protein_coding protein_coding 16.28547 19.73519 19.52752 0.1693314 1.090841 -0.01525429 1.2605960 1.1230364 0.000000 1.12303641 0.00000000 -6.82405042 0.08121667 0.05763333 0.00000000 -0.05763333 9.020358e-01 7.068671e-18 FALSE FALSE
ENST00000401878 ENSG00000184863 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM33 protein_coding protein_coding 16.28547 19.73519 19.52752 0.1693314 1.090841 -0.01525429 6.0838582 6.9280448 8.853356 0.78641901 0.67429611 0.35332396 0.36730833 0.35050000 0.45406667 0.10356667 5.098369e-01 7.068671e-18 FALSE TRUE
ENST00000440108 ENSG00000184863 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM33 protein_coding protein_coding 16.28547 19.73519 19.52752 0.1693314 1.090841 -0.01525429 1.3858335 0.0000000 4.399931 0.00000000 1.15593083 8.78461231 0.08030833 0.00000000 0.22000000 0.22000000 3.627152e-13 7.068671e-18 FALSE TRUE
MSTRG.30985.1 ENSG00000184863 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM33 protein_coding   16.28547 19.73519 19.52752 0.1693314 1.090841 -0.01525429 0.4673229 1.1430015 0.000000 0.43313523 0.00000000 -6.84925062 0.02939167 0.05793333 0.00000000 -0.05793333 1.818182e-04 7.068671e-18 FALSE TRUE
MSTRG.30985.5 ENSG00000184863 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM33 protein_coding   16.28547 19.73519 19.52752 0.1693314 1.090841 -0.01525429 2.6557901 3.7113896 3.953572 0.05047481 0.73425767 0.09095964 0.15857083 0.18803333 0.20623333 0.01820000 9.839151e-01 7.068671e-18 FALSE TRUE
MSTRG.30985.6 ENSG00000184863 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM33 protein_coding   16.28547 19.73519 19.52752 0.1693314 1.090841 -0.01525429 0.4844356 1.0814330 0.000000 1.08143301 0.00000000 -6.77007977 0.03141667 0.05500000 0.00000000 -0.05500000 9.005057e-01 7.068671e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000184863 E001 5.8131771 0.0050014995 3.792624e-02 1.494200e-01 7 155644451 155644649 199 + 0.611 0.964 1.410
ENSG00000184863 E002 4.2645565 0.0530778767 4.221591e-02 1.604717e-01 7 155644650 155644660 11 + 0.434 0.870 1.901
ENSG00000184863 E003 4.9131679 0.0400076863 3.009841e-02 1.276255e-01 7 155644661 155644667 7 + 0.485 0.920 1.833
ENSG00000184863 E004 14.3170128 0.0822990837 1.333294e-01 3.370169e-01 7 155644668 155644701 34 + 0.976 1.311 1.205
ENSG00000184863 E005 84.9673816 0.0089235579 7.019953e-01 8.368480e-01 7 155644702 155644919 218 + 1.899 1.963 0.215
ENSG00000184863 E006 92.0464393 0.0004800121 4.193476e-07 1.328388e-05 7 155665175 155665253 79 + 2.021 1.919 -0.342
ENSG00000184863 E007 66.9835848 0.0005597162 6.010849e-08 2.353113e-06 7 155672867 155672879 13 + 1.904 1.755 -0.504
ENSG00000184863 E008 84.0995270 0.0005190850 3.740849e-10 2.352901e-08 7 155672880 155672915 36 + 2.006 1.848 -0.532
ENSG00000184863 E009 122.7423882 0.0013568545 1.264637e-09 7.253104e-08 7 155678608 155678684 77 + 2.158 2.028 -0.437
ENSG00000184863 E010 152.2559127 0.0065186630 7.135234e-07 2.117293e-05 7 155680590 155680668 79 + 2.259 2.107 -0.508
ENSG00000184863 E011 278.4967133 0.0024231018 1.547412e-17 3.297191e-15 7 155680669 155680908 240 + 2.531 2.352 -0.596
ENSG00000184863 E012 5.7023687 0.0051347064 8.166568e-02 2.481430e-01 7 155684933 155685052 120 + 0.895 0.745 -0.589
ENSG00000184863 E013 173.0809917 0.0019355439 2.736825e-11 2.182046e-09 7 155700773 155700890 118 + 2.308 2.170 -0.459
ENSG00000184863 E014 122.5790233 0.0022468406 5.596299e-06 1.271582e-04 7 155700891 155700944 54 + 2.135 2.045 -0.300
ENSG00000184863 E015 10.0843052 0.0038196001 1.962751e-02 9.464217e-02 7 155700945 155701490 546 + 1.125 0.963 -0.593
ENSG00000184863 E016 0.5233527 0.0224547361 3.987768e-01   7 155706814 155706859 46 + 0.227 0.115 -1.174
ENSG00000184863 E017 161.0998798 0.0044135197 2.471415e-02 1.113419e-01 7 155706860 155707068 209 + 2.215 2.207 -0.026
ENSG00000184863 E018 0.0000000       7 155707294 155707380 87 +      
ENSG00000184863 E019 17.3742157 0.0199785528 8.783413e-01 9.404716e-01 7 155711173 155711202 30 + 1.214 1.317 0.361
ENSG00000184863 E020 121.6026645 0.0035396499 5.872842e-01 7.618195e-01 7 155711203 155711455 253 + 2.055 2.119 0.213
ENSG00000184863 E021 76.8514918 0.0030090833 2.507307e-02 1.124525e-01 7 155718385 155718443 59 + 1.904 1.884 -0.066
ENSG00000184863 E022 102.3504679 0.0017609146 1.235734e-02 6.786358e-02 7 155737530 155737662 133 + 2.023 2.012 -0.039
ENSG00000184863 E023 151.6828136 0.0020258019 4.078933e-02 1.567582e-01 7 155738060 155738403 344 + 2.177 2.193 0.051
ENSG00000184863 E024 0.8265952 0.0168080013 9.278791e-01   7 155738404 155739714 1311 + 0.227 0.281 0.410
ENSG00000184863 E025 75.8402735 0.0007634340 5.676459e-01 7.485233e-01 7 155739715 155740026 312 + 1.825 1.936 0.372
ENSG00000184863 E026 156.1526042 0.0003748008 1.945130e-03 1.669942e-02 7 155741819 155742106 288 + 2.197 2.194 -0.010
ENSG00000184863 E027 336.5937467 0.0076993406 2.770091e-01 5.170245e-01 7 155744961 155745602 642 + 2.507 2.545 0.129
ENSG00000184863 E028 1.3855550 0.0273658127 1.533443e-01   7 155745603 155745720 118 + 0.485 0.281 -1.173
ENSG00000184863 E029 0.3336024 0.0274424043 3.011686e-01   7 155746419 155746585 167 + 0.000 0.206 25.088
ENSG00000184863 E030 0.3336024 0.0274424043 3.011686e-01   7 155746586 155746665 80 + 0.000 0.206 25.088
ENSG00000184863 E031 20.0921666 0.0018247379 4.479516e-01 6.642087e-01 7 155763809 155763811 3 + 1.234 1.376 0.499
ENSG00000184863 E032 155.9720786 0.0053705204 1.899892e-01 4.169244e-01 7 155763812 155764018 207 + 2.111 2.257 0.488
ENSG00000184863 E033 109.7534367 0.0063462672 9.713517e-02 2.767594e-01 7 155766467 155766555 89 + 1.942 2.112 0.573
ENSG00000184863 E034 114.0637111 0.0018962950 6.144248e-02 2.060088e-01 7 155766556 155766655 100 + 1.964 2.124 0.537
ENSG00000184863 E035 7.8801701 0.0042933586 3.600012e-06 8.676765e-05 7 155766656 155766896 241 + 0.434 1.139 2.896
ENSG00000184863 E036 118.5653894 0.0004259377 6.977768e-01 8.340878e-01 7 155774559 155774647 89 + 2.035 2.109 0.247
ENSG00000184863 E037 121.6994546 0.0003507261 4.029719e-01 6.307273e-01 7 155774993 155775097 105 + 2.054 2.113 0.199
ENSG00000184863 E038 2618.6852852 0.0067976741 2.688375e-07 8.958948e-06 7 155775098 155781485 6388 + 3.293 3.502 0.695