ENSG00000184787

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000345496 ENSG00000184787 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE2G2 protein_coding protein_coding 102.6068 82.76834 119.1069 7.550069 4.842652 0.5250527 6.503895 6.749289 5.454199 1.4082580 0.6182039 -0.30686148 0.06776250 0.08466667 0.04623333 -0.03843333 0.59557611 0.01954904 FALSE TRUE
ENST00000462569 ENSG00000184787 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE2G2 protein_coding retained_intron 102.6068 82.76834 119.1069 7.550069 4.842652 0.5250527 16.858322 10.291844 26.113250 2.6441096 0.9651238 1.34243185 0.15334583 0.12320000 0.21956667 0.09636667 0.19133642 0.01954904   FALSE
ENST00000481546 ENSG00000184787 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE2G2 protein_coding retained_intron 102.6068 82.76834 119.1069 7.550069 4.842652 0.5250527 10.644475 7.161124 14.815778 1.9138003 0.5825306 1.04783667 0.09912500 0.08613333 0.12516667 0.03903333 0.60745495 0.01954904 FALSE TRUE
ENST00000497630 ENSG00000184787 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE2G2 protein_coding processed_transcript 102.6068 82.76834 119.1069 7.550069 4.842652 0.5250527 9.729460 3.706477 14.308772 0.3583995 2.2076602 1.94590038 0.08552917 0.04646667 0.11913333 0.07266667 0.01954904 0.01954904 FALSE TRUE
ENST00000497664 ENSG00000184787 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE2G2 protein_coding processed_transcript 102.6068 82.76834 119.1069 7.550069 4.842652 0.5250527 5.256722 4.429813 3.683938 2.3640646 0.3929361 -0.26533958 0.05122083 0.04910000 0.03110000 -0.01800000 1.00000000 0.01954904 FALSE FALSE
MSTRG.21466.2 ENSG00000184787 HEK293_OSMI2_6hA HEK293_TMG_6hB UBE2G2 protein_coding   102.6068 82.76834 119.1069 7.550069 4.842652 0.5250527 48.489638 45.875429 48.782809 5.0420238 3.1221398 0.08863245 0.49440833 0.55453333 0.40890000 -0.14563333 0.09972383 0.01954904 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000184787 E001 2.6880771 0.1446176497 7.728568e-01 0.8803921349 21 44768580 44769039 460 - 0.537 0.606 0.314
ENSG00000184787 E002 3174.8896424 0.0041575477 4.441447e-05 0.0007526041 21 44769040 44770930 1891 - 3.444 3.557 0.373
ENSG00000184787 E003 251.1823681 0.0004775068 4.729655e-01 0.6821325441 21 44770931 44770971 41 - 2.377 2.412 0.118
ENSG00000184787 E004 927.5208610 0.0003620535 3.301190e-01 0.5690715201 21 44770972 44771278 307 - 2.961 2.967 0.021
ENSG00000184787 E005 400.5119846 0.0017405993 1.968992e-01 0.4256583495 21 44771279 44771294 16 - 2.607 2.595 -0.040
ENSG00000184787 E006 800.7767475 0.0023516817 3.442571e-01 0.5818576709 21 44771295 44771489 195 - 2.904 2.902 -0.007
ENSG00000184787 E007 272.6162489 0.0020919854 8.312853e-01 0.9145367607 21 44773547 44773547 1 - 2.423 2.448 0.082
ENSG00000184787 E008 579.1800537 0.0015567047 7.189824e-01 0.8475441696 21 44773548 44773687 140 - 2.756 2.767 0.038
ENSG00000184787 E009 224.5624859 0.0185623399 1.789796e-02 0.0887078154 21 44773688 44774530 843 - 2.406 2.281 -0.416
ENSG00000184787 E010 52.1952731 0.0577093445 2.666597e-01 0.5061661959 21 44774531 44774566 36 - 1.752 1.690 -0.211
ENSG00000184787 E011 99.0369769 0.0333436957 1.061124e-02 0.0607242903 21 44774567 44774720 154 - 2.077 1.887 -0.637
ENSG00000184787 E012 58.7440851 0.0253322941 1.183894e-02 0.0657872794 21 44774721 44774741 21 - 1.850 1.666 -0.624
ENSG00000184787 E013 80.3705362 0.0163208676 5.750940e-03 0.0384989677 21 44774742 44774820 79 - 1.979 1.810 -0.566
ENSG00000184787 E014 241.3257592 0.0492425204 2.637164e-02 0.1163974804 21 44774821 44775436 616 - 2.457 2.281 -0.589
ENSG00000184787 E015 136.0484900 0.0378944285 1.837966e-04 0.0024924453 21 44776834 44777253 420 - 2.257 1.940 -1.060
ENSG00000184787 E016 44.5604537 0.0257034902 4.526700e-04 0.0052459248 21 44777254 44777298 45 - 1.769 1.475 -1.002
ENSG00000184787 E017 481.9807593 0.0002919344 9.340211e-02 0.2700442322 21 44777299 44777376 78 - 2.684 2.672 -0.040
ENSG00000184787 E018 397.9063394 0.0001521710 1.046117e-01 0.2899727632 21 44777377 44777417 41 - 2.601 2.588 -0.041
ENSG00000184787 E019 2.4745515 0.0359685471 6.949272e-01 0.8322551927 21 44779144 44779216 73 - 0.491 0.579 0.413
ENSG00000184787 E020 0.7962354 0.0168166540 5.771371e-01   21 44785666 44785791 126 - 0.204 0.310 0.796
ENSG00000184787 E021 374.6320884 0.0001735375 5.811852e-02 0.1985569960 21 44787920 44787965 46 - 2.578 2.560 -0.061
ENSG00000184787 E022 322.3481111 0.0006947804 8.256680e-01 0.9113159211 21 44788060 44788095 36 - 2.497 2.511 0.046
ENSG00000184787 E023 10.4601348 0.0401306915 3.684332e-01 0.6027684326 21 44799391 44799480 90 - 1.104 0.989 -0.421
ENSG00000184787 E024 37.8605335 0.0073429696 4.029720e-01 0.6307273070 21 44799990 44801283 1294 - 1.543 1.626 0.285
ENSG00000184787 E025 16.8889053 0.0089535163 7.028610e-01 0.8373797051 21 44801284 44801398 115 - 1.228 1.279 0.178
ENSG00000184787 E026 278.1058147 0.0002438464 9.539118e-01 0.9788918780 21 44801706 44801826 121 - 2.431 2.450 0.062