ENSG00000184677

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374651 ENSG00000184677 HEK293_OSMI2_6hA HEK293_TMG_6hB ZBTB40 protein_coding protein_coding 9.724651 13.46179 10.51648 0.4008634 0.3131829 -0.3559193 0.8174320 0.9019399 0.091293 0.0615964 0.05173837 -3.1704043 0.09069167 0.06713333 0.0088000 -0.05833333 0.00402451 0.00402451 FALSE TRUE
ENST00000375647 ENSG00000184677 HEK293_OSMI2_6hA HEK293_TMG_6hB ZBTB40 protein_coding protein_coding 9.724651 13.46179 10.51648 0.4008634 0.3131829 -0.3559193 7.4748195 10.7849229 8.995566 0.2906648 0.28979711 -0.2614641 0.75975417 0.80203333 0.8562667 0.05423333 0.71760144 0.00402451 FALSE TRUE
MSTRG.506.3 ENSG00000184677 HEK293_OSMI2_6hA HEK293_TMG_6hB ZBTB40 protein_coding   9.724651 13.46179 10.51648 0.4008634 0.3131829 -0.3559193 0.6405754 0.8031489 0.000000 0.4035996 0.00000000 -6.3454476 0.06872083 0.05840000 0.0000000 -0.05840000 0.29029379 0.00402451 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000184677 E001 0.0000000       1 22428838 22428851 14 +      
ENSG00000184677 E002 0.2852693 0.2435245011 1.534615e-01   1 22428852 22428859 8 + 0.243 0.000 -11.133
ENSG00000184677 E003 0.2852693 0.2435245011 1.534615e-01   1 22428860 22428861 2 + 0.243 0.000 -13.009
ENSG00000184677 E004 0.5587721 0.4184582410 3.390330e-01   1 22428862 22428870 9 + 0.324 0.103 -2.054
ENSG00000184677 E005 2.6598126 0.1371864110 5.816231e-01 7.581796e-01 1 22428871 22428886 16 + 0.606 0.557 -0.221
ENSG00000184677 E006 15.8188685 0.0261381109 4.995010e-01 7.004355e-01 1 22428887 22429014 128 + 1.153 1.275 0.430
ENSG00000184677 E007 0.1308682 0.0311095918 7.113246e-01   1 22451851 22451861 11 + 0.000 0.105 12.143
ENSG00000184677 E008 5.2602069 0.1054433348 4.383835e-02 1.647071e-01 1 22451862 22451866 5 + 0.956 0.608 -1.395
ENSG00000184677 E009 34.2040376 0.0083692653 9.472903e-07 2.709190e-05 1 22451867 22452004 138 + 1.693 1.378 -1.079
ENSG00000184677 E010 2.6927564 0.0596072663 5.360790e-01 7.263712e-01 1 22452659 22452946 288 + 0.607 0.538 -0.309
ENSG00000184677 E011 190.0568225 0.0003294203 3.629854e-13 4.047490e-11 1 22489880 22490645 766 + 2.354 2.210 -0.479
ENSG00000184677 E012 67.9315953 0.0007192852 1.908876e-02 9.277138e-02 1 22491400 22491533 134 + 1.868 1.811 -0.192
ENSG00000184677 E013 58.1818416 0.0006322970 2.194472e-02 1.023900e-01 1 22501492 22501554 63 + 1.800 1.737 -0.211
ENSG00000184677 E014 76.5080525 0.0007236735 1.688316e-02 8.502563e-02 1 22501555 22501684 130 + 1.914 1.861 -0.180
ENSG00000184677 E015 53.2808894 0.0009867589 1.488681e-02 7.766173e-02 1 22502299 22502340 42 + 1.767 1.691 -0.257
ENSG00000184677 E016 71.4481594 0.0034921331 4.533653e-02 1.684325e-01 1 22502341 22502441 101 + 1.884 1.830 -0.182
ENSG00000184677 E017 104.1151214 0.0004747828 6.763785e-04 7.237391e-03 1 22506049 22506241 193 + 2.058 1.984 -0.249
ENSG00000184677 E018 86.4349046 0.0004273336 9.307502e-06 1.972087e-04 1 22508001 22508137 137 + 2.003 1.879 -0.418
ENSG00000184677 E019 98.8095899 0.0004767795 2.157076e-05 4.073403e-04 1 22508530 22508731 202 + 2.054 1.947 -0.360
ENSG00000184677 E020 95.0180594 0.0004879797 2.837785e-04 3.564506e-03 1 22509100 22509233 134 + 2.026 1.937 -0.296
ENSG00000184677 E021 95.8079506 0.0045399351 1.044897e-01 2.897527e-01 1 22511179 22511347 169 + 1.994 1.964 -0.101
ENSG00000184677 E022 170.6210731 0.0036940621 5.461502e-02 1.904693e-01 1 22511676 22512134 459 + 2.243 2.215 -0.094
ENSG00000184677 E023 101.2084657 0.0004070502 2.075114e-01 4.388350e-01 1 22512924 22513130 207 + 2.003 2.003 0.001
ENSG00000184677 E024 103.9350622 0.0004239252 8.613835e-01 9.311263e-01 1 22517300 22517464 165 + 1.985 2.036 0.173
ENSG00000184677 E025 111.2953482 0.0023783986 5.429043e-01 7.311573e-01 1 22520061 22520275 215 + 2.034 2.056 0.071
ENSG00000184677 E026 106.6336787 0.0005215460 6.478380e-01 8.021066e-01 1 22521496 22521658 163 + 2.008 2.038 0.099
ENSG00000184677 E027 73.0636917 0.0006254942 6.427496e-01 7.986836e-01 1 22522377 22522463 87 + 1.849 1.874 0.084
ENSG00000184677 E028 126.2564082 0.0006413901 9.108135e-01 9.575334e-01 1 22524218 22524444 227 + 2.070 2.112 0.141
ENSG00000184677 E029 163.0386298 0.0003244524 2.633416e-01 5.025391e-01 1 22526202 22526490 289 + 2.159 2.236 0.259
ENSG00000184677 E030 425.3642730 0.0002399248 2.278776e-03 1.891255e-02 1 22526491 22527585 1095 + 2.560 2.660 0.333
ENSG00000184677 E031 1222.9914996 0.0050173559 4.582466e-07 1.434221e-05 1 22527586 22531157 3572 + 2.972 3.144 0.571
ENSG00000184677 E032 0.2027342 0.0391734890 7.094078e-01   1 22552059 22552109 51 + 0.000 0.105 12.030