ENSG00000184508

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330334 ENSG00000184508 HEK293_OSMI2_6hA HEK293_TMG_6hB HDDC3 protein_coding protein_coding 48.67834 62.305 23.02186 12.46674 0.1987605 -1.435949 13.397431 15.965724 6.685619 2.5746359 0.51256926 -1.2545920 0.28265000 0.26173333 0.29043333 0.02870000 0.85620079 0.04518978 FALSE TRUE
ENST00000394272 ENSG00000184508 HEK293_OSMI2_6hA HEK293_TMG_6hB HDDC3 protein_coding protein_coding 48.67834 62.305 23.02186 12.46674 0.1987605 -1.435949 4.519101 5.228452 2.445936 0.8639980 0.11626368 -1.0928673 0.09217500 0.08550000 0.10626667 0.02076667 0.60834835 0.04518978 FALSE TRUE
ENST00000494993 ENSG00000184508 HEK293_OSMI2_6hA HEK293_TMG_6hB HDDC3 protein_coding retained_intron 48.67834 62.305 23.02186 12.46674 0.1987605 -1.435949 11.337557 13.287996 7.180742 2.7887732 0.45281256 -0.8869963 0.24576667 0.21216667 0.31183333 0.09966667 0.04518978 0.04518978   FALSE
ENST00000559834 ENSG00000184508 HEK293_OSMI2_6hA HEK293_TMG_6hB HDDC3 protein_coding retained_intron 48.67834 62.305 23.02186 12.46674 0.1987605 -1.435949 2.603572 2.518792 1.924083 0.1283969 0.08120905 -0.3867983 0.06184583 0.04540000 0.08366667 0.03826667 0.33167313 0.04518978   FALSE
ENST00000559898 ENSG00000184508 HEK293_OSMI2_6hA HEK293_TMG_6hB HDDC3 protein_coding protein_coding 48.67834 62.305 23.02186 12.46674 0.1987605 -1.435949 3.220995 4.034286 2.458420 0.2762791 0.05222896 -0.7122967 0.07859167 0.06996667 0.10683333 0.03686667 0.43227981 0.04518978 FALSE TRUE
ENST00000646620 ENSG00000184508 HEK293_OSMI2_6hA HEK293_TMG_6hB HDDC3 protein_coding protein_coding 48.67834 62.305 23.02186 12.46674 0.1987605 -1.435949 11.919690 18.688095 1.748804 5.5285545 1.00760674 -3.4102247 0.20762917 0.28410000 0.07573333 -0.20836667 0.51719676 0.04518978 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000184508 E001 26.816976 0.001304688 0.14715385 0.35825155 15 90929968 90930311 344 - 1.395 1.365 -0.102
ENSG00000184508 E002 47.019588 0.012279521 0.03044728 0.12868711 15 90930312 90930917 606 - 1.670 1.584 -0.292
ENSG00000184508 E003 10.405003 0.003199645 0.30923066 0.54970563 15 90930918 90930924 7 - 1.022 0.980 -0.154
ENSG00000184508 E004 207.269525 0.325958555 0.28941873 0.52994181 15 90930925 90931098 174 - 2.074 2.277 0.679
ENSG00000184508 E005 201.851673 0.816138781 0.36839634 0.60273584 15 90931099 90931150 52 - 2.029 2.271 0.811
ENSG00000184508 E006 479.064547 1.228726084 0.45943677 0.67274036 15 90931151 90931336 186 - 2.436 2.639 0.679
ENSG00000184508 E007 315.793661 1.045714237 0.43428300 0.65445548 15 90931337 90931405 69 - 2.256 2.459 0.679
ENSG00000184508 E008 34.632388 0.146562529 0.61216318 0.77829642 15 90931406 90931556 151 - 1.415 1.491 0.262
ENSG00000184508 E009 17.923960 0.006192607 0.19979580 0.42941612 15 90931557 90931703 147 - 1.247 1.199 -0.169
ENSG00000184508 E010 585.104421 0.010993922 0.30043601 0.54089416 15 90931704 90931944 241 - 2.638 2.702 0.212
ENSG00000184508 E011 20.339233 0.062156901 0.03424336 0.13951450 15 90931945 90932054 110 - 1.405 1.199 -0.721
ENSG00000184508 E012 298.305126 0.049646496 0.20842981 0.43995690 15 90932055 90932110 56 - 2.402 2.395 -0.022
ENSG00000184508 E013 73.192081 0.079697766 0.01201436 0.06650525 15 90932111 90932385 275 - 1.974 1.721 -0.851
ENSG00000184508 E014 19.526244 0.094976625 0.13772552 0.34403346 15 90932386 90932428 43 - 1.345 1.202 -0.503
ENSG00000184508 E015 244.596578 0.056281553 0.41904983 0.64290601 15 90932429 90932601 173 - 2.284 2.318 0.113
ENSG00000184508 E016 4.524244 0.006080365 0.01439114 0.07584712 15 90932602 90932755 154 - 0.203 0.757 2.984
ENSG00000184508 E017 3.815413 0.008051178 0.44087179 0.65938035 15 90932756 90932806 51 - 0.445 0.653 0.968
ENSG00000184508 E018 13.793465 0.345871581 0.41013581 0.63611341 15 90932807 90934984 2178 - 1.199 1.059 -0.502
ENSG00000184508 E019 6.470328 0.087154060 0.31103866 0.55142581 15 90934985 90935196 212 - 0.599 0.857 1.056