ENSG00000184445

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000423927 ENSG00000184445 HEK293_OSMI2_6hA HEK293_TMG_6hB KNTC1 protein_coding protein_coding 11.70526 7.984237 14.46029 1.391869 0.2563765 0.8560619 1.6806178 1.3913009 1.848946 0.4154454 0.07591041 0.4077183 0.14024167 0.16743333 0.1278667 -0.03956667 6.532238e-01 1.694534e-05 FALSE FALSE
MSTRG.8222.1 ENSG00000184445 HEK293_OSMI2_6hA HEK293_TMG_6hB KNTC1 protein_coding   11.70526 7.984237 14.46029 1.391869 0.2563765 0.8560619 4.8501557 1.2719632 8.547490 0.3793932 0.34441487 2.7388328 0.34686667 0.15683333 0.5917000 0.43486667 1.694534e-05 1.694534e-05 FALSE TRUE
MSTRG.8222.6 ENSG00000184445 HEK293_OSMI2_6hA HEK293_TMG_6hB KNTC1 protein_coding   11.70526 7.984237 14.46029 1.391869 0.2563765 0.8560619 0.2653936 0.4006466 0.000000 0.1906424 0.00000000 -5.3598254 0.03534583 0.05993333 0.0000000 -0.05993333 1.738021e-03 1.694534e-05 FALSE TRUE
MSTRG.8222.7 ENSG00000184445 HEK293_OSMI2_6hA HEK293_TMG_6hB KNTC1 protein_coding   11.70526 7.984237 14.46029 1.391869 0.2563765 0.8560619 2.6134416 2.9781434 1.909040 0.3140400 0.25146749 -0.6388648 0.26415000 0.38240000 0.1320333 -0.25036667 4.645588e-05 1.694534e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000184445 E001 1.6581343 0.3474545159 6.318088e-01 7.915812e-01 12 122527198 122527245 48 + 0.446 0.299 -0.856
ENSG00000184445 E002 1.6581343 0.3474545159 6.318088e-01 7.915812e-01 12 122527246 122527247 2 + 0.446 0.299 -0.856
ENSG00000184445 E003 1.6581343 0.3474545159 6.318088e-01 7.915812e-01 12 122527248 122527248 1 + 0.446 0.299 -0.856
ENSG00000184445 E004 26.4030662 0.0033580445 3.865979e-04 4.601431e-03 12 122527249 122527351 103 + 1.461 1.158 -1.060
ENSG00000184445 E005 0.9103477 0.0167435089 5.659858e-03   12 122527456 122527680 225 + 0.080 0.553 3.672
ENSG00000184445 E006 0.1426347 0.0330096286 1.000000e+00   12 122529991 122530021 31 + 0.080 0.000 -7.797
ENSG00000184445 E007 42.3479735 0.0010970059 3.405947e-07 1.104317e-05 12 122530022 122530192 171 + 1.669 1.324 -1.184
ENSG00000184445 E008 32.9499397 0.0013350649 1.340548e-04 1.909545e-03 12 122534664 122534784 121 + 1.551 1.268 -0.980
ENSG00000184445 E009 31.9391153 0.0202085661 2.650484e-02 1.167881e-01 12 122538339 122538454 116 + 1.529 1.308 -0.764
ENSG00000184445 E010 31.0603318 0.0036226185 4.157144e-05 7.111888e-04 12 122539676 122539754 79 + 1.536 1.202 -1.162
ENSG00000184445 E011 23.7017001 0.0015088562 1.267124e-06 3.487919e-05 12 122542050 122542127 78 + 1.439 0.989 -1.595
ENSG00000184445 E012 15.7800043 0.0026825170 1.410544e-02 7.476833e-02 12 122543600 122543634 35 + 1.240 0.989 -0.903
ENSG00000184445 E013 25.0922856 0.0013371568 7.708314e-05 1.202949e-03 12 122544159 122544269 111 + 1.448 1.109 -1.191
ENSG00000184445 E014 28.9109809 0.0013053947 2.497321e-06 6.339350e-05 12 122546176 122546269 94 + 1.514 1.126 -1.357
ENSG00000184445 E015 25.8139150 0.0015211897 1.138238e-05 2.343238e-04 12 122546622 122546674 53 + 1.469 1.091 -1.328
ENSG00000184445 E016 34.6493576 0.0247684142 2.892486e-04 3.621162e-03 12 122547415 122547530 116 + 1.595 1.209 -1.338
ENSG00000184445 E017 25.6664127 0.1064302587 3.912866e-02 1.524910e-01 12 122547915 122547969 55 + 1.460 1.135 -1.138
ENSG00000184445 E018 17.2285532 0.0041812450 2.334751e-05 4.358039e-04 12 122549766 122549779 14 + 1.318 0.856 -1.680
ENSG00000184445 E019 29.3326400 0.0033971442 5.879332e-06 1.326662e-04 12 122549780 122549864 85 + 1.525 1.142 -1.337
ENSG00000184445 E020 23.2315033 0.0018847314 1.742081e-05 3.396618e-04 12 122551319 122551362 44 + 1.426 1.033 -1.390
ENSG00000184445 E021 29.7950579 0.0155524991 9.781822e-04 9.742410e-03 12 122551458 122551523 66 + 1.518 1.186 -1.153
ENSG00000184445 E022 31.4928319 0.0061115176 3.535599e-04 4.273495e-03 12 122551621 122551696 76 + 1.534 1.230 -1.057
ENSG00000184445 E023 35.8825449 0.0009655433 5.920928e-06 1.334098e-04 12 122557384 122557509 126 + 1.595 1.268 -1.131
ENSG00000184445 E024 31.9404330 0.0012062912 3.427672e-05 6.044626e-04 12 122557600 122557689 90 + 1.546 1.230 -1.095
ENSG00000184445 E025 22.6527368 0.0018932203 4.767759e-05 7.988902e-04 12 122561921 122561974 54 + 1.409 1.033 -1.331
ENSG00000184445 E026 23.8916428 0.0033206043 2.752034e-04 3.479701e-03 12 122562638 122562699 62 + 1.423 1.092 -1.166
ENSG00000184445 E027 27.5281185 0.0019127531 7.412358e-05 1.164779e-03 12 122568261 122568372 112 + 1.487 1.158 -1.147
ENSG00000184445 E028 32.2296286 0.0052411564 3.606702e-03 2.696816e-02 12 122569681 122569824 144 + 1.537 1.303 -0.809
ENSG00000184445 E029 25.4537995 0.0027412660 1.393750e-04 1.973081e-03 12 122570876 122570932 57 + 1.457 1.126 -1.161
ENSG00000184445 E030 29.0303386 0.0025257183 2.995317e-04 3.724637e-03 12 122571025 122571126 102 + 1.506 1.216 -1.007
ENSG00000184445 E031 35.7309431 0.0011600710 2.130101e-05 4.033677e-04 12 122572937 122573056 120 + 1.595 1.291 -1.049
ENSG00000184445 E032 43.5475964 0.0009167977 3.566966e-06 8.617911e-05 12 122573142 122573285 144 + 1.676 1.374 -1.034
ENSG00000184445 E033 37.6085657 0.0009871554 8.609884e-06 1.842667e-04 12 122574282 122574380 99 + 1.615 1.302 -1.075
ENSG00000184445 E034 38.1546951 0.0010561987 1.295014e-04 1.854795e-03 12 122575543 122575646 104 + 1.615 1.355 -0.893
ENSG00000184445 E035 43.5294186 0.0010733929 8.944408e-07 2.577577e-05 12 122575800 122575899 100 + 1.680 1.355 -1.115
ENSG00000184445 E036 40.8729636 0.0013836005 4.148608e-07 1.315401e-05 12 122576895 122577029 135 + 1.655 1.302 -1.214
ENSG00000184445 E037 35.1926873 0.0061917728 1.669640e-03 1.481035e-02 12 122577672 122577791 120 + 1.577 1.324 -0.870
ENSG00000184445 E038 31.9802551 0.0018369924 1.053709e-03 1.031973e-02 12 122579905 122579977 73 + 1.535 1.291 -0.845
ENSG00000184445 E039 29.5277932 0.0025643919 1.615080e-03 1.443089e-02 12 122580603 122580670 68 + 1.504 1.255 -0.861
ENSG00000184445 E040 54.4385849 0.0079124669 8.230024e-03 5.038201e-02 12 122582705 122582985 281 + 1.749 1.562 -0.636
ENSG00000184445 E041 39.6821872 0.0009640304 3.307563e-02 1.362755e-01 12 122584278 122584450 173 + 1.602 1.468 -0.460
ENSG00000184445 E042 30.5098590 0.0092826594 1.811014e-01 4.054097e-01 12 122584893 122584990 98 + 1.490 1.381 -0.373
ENSG00000184445 E043 37.8588513 0.0010375247 3.478264e-03 2.621325e-02 12 122585636 122585774 139 + 1.595 1.402 -0.664
ENSG00000184445 E044 28.7578562 0.0012161943 2.503342e-03 2.035357e-02 12 122586701 122586757 57 + 1.487 1.255 -0.803
ENSG00000184445 E045 50.0247306 0.0007318815 1.994160e-02 9.568215e-02 12 122587711 122587874 164 + 1.700 1.569 -0.444
ENSG00000184445 E046 45.0843816 0.0008285372 9.532610e-03 5.611210e-02 12 122588712 122588816 105 + 1.659 1.504 -0.530
ENSG00000184445 E047 47.3174288 0.0007573186 9.759617e-04 9.723265e-03 12 122590607 122590735 129 + 1.687 1.490 -0.673
ENSG00000184445 E048 46.3666113 0.0010273191 9.984798e-03 5.809800e-02 12 122591337 122591453 117 + 1.671 1.518 -0.522
ENSG00000184445 E049 23.5333088 0.0084291938 3.251836e-03 2.491480e-02 12 122592818 122593184 367 + 1.256 1.505 0.866
ENSG00000184445 E050 28.7345554 0.0086855598 3.533620e-07 1.139555e-05 12 122593416 122593912 497 + 1.273 1.680 1.401
ENSG00000184445 E051 24.3344626 0.0277816014 4.285469e-02 1.621666e-01 12 122593913 122594275 363 + 1.278 1.508 0.798
ENSG00000184445 E052 40.9496804 0.0010827582 3.253893e-01 5.646236e-01 12 122594276 122594385 110 + 1.565 1.625 0.205
ENSG00000184445 E053 6.1458583 0.0340226143 1.494432e-01 3.614608e-01 12 122597243 122597730 488 + 0.749 0.967 0.841
ENSG00000184445 E054 49.3754405 0.0007170813 4.125981e-01 6.380456e-01 12 122597731 122597938 208 + 1.648 1.694 0.158
ENSG00000184445 E055 32.0425842 0.0011287197 1.257116e-01 3.249994e-01 12 122601536 122601625 90 + 1.448 1.550 0.351
ENSG00000184445 E056 2.4055185 0.0096765512 1.401344e-01 3.477162e-01 12 122601851 122601951 101 + 0.417 0.664 1.161
ENSG00000184445 E057 2.3656007 0.4104795986 2.212448e-01 4.549935e-01 12 122602397 122602568 172 + 0.301 0.769 2.281
ENSG00000184445 E058 58.7911680 0.0017705914 4.593870e-02 1.698867e-01 12 122602569 122602740 172 + 1.704 1.809 0.353
ENSG00000184445 E059 2.5403308 0.0202155036 8.178225e-02 2.483550e-01 12 122602823 122602828 6 + 0.417 0.710 1.358
ENSG00000184445 E060 39.7388646 0.0010429656 7.946176e-02 2.437579e-01 12 122602829 122602887 59 + 1.535 1.641 0.361
ENSG00000184445 E061 2.0576062 0.1619669400 1.593744e-02 8.156660e-02 12 122602888 122603026 139 + 0.208 0.759 2.950
ENSG00000184445 E062 84.5288866 0.0031826144 1.950517e-03 1.673704e-02 12 122603027 122603243 217 + 1.844 1.991 0.494
ENSG00000184445 E063 53.1553357 0.0007176636 4.906740e-03 3.413252e-02 12 122604564 122604637 74 + 1.642 1.788 0.494
ENSG00000184445 E064 91.0862014 0.0004967541 1.923611e-04 2.590796e-03 12 122604877 122605087 211 + 1.871 2.020 0.500
ENSG00000184445 E065 46.7398064 0.0008588583 1.212908e-02 6.697003e-02 12 122605306 122605358 53 + 1.591 1.729 0.470
ENSG00000184445 E066 50.2066345 0.0009860953 1.938465e-05 3.723093e-04 12 122605359 122605415 57 + 1.588 1.813 0.761
ENSG00000184445 E067 0.5117739 0.0217681645 8.503605e-01   12 122609197 122609383 187 + 0.147 0.181 0.352
ENSG00000184445 E068 41.1901304 0.0011907962 3.796152e-05 6.593780e-04 12 122609384 122609430 47 + 1.496 1.733 0.810
ENSG00000184445 E069 43.8205042 0.0011299961 9.816651e-06 2.063234e-04 12 122610822 122610860 39 + 1.517 1.765 0.843
ENSG00000184445 E070 42.2107609 0.0008479816 1.759086e-04 2.402359e-03 12 122610861 122610900 40 + 1.520 1.733 0.725
ENSG00000184445 E071 0.9960209 0.2551821143 6.376980e-01   12 122610901 122611765 865 + 0.306 0.182 -0.976
ENSG00000184445 E072 1.0239076 0.0380202187 6.018588e-02   12 122612882 122613111 230 + 0.147 0.488 2.362
ENSG00000184445 E073 75.7916610 0.0006805156 2.335011e-10 1.531628e-08 12 122613112 122613230 119 + 1.746 2.015 0.907
ENSG00000184445 E074 0.3503582 0.0269410508 4.932590e-01   12 122613450 122613625 176 + 0.080 0.181 1.352
ENSG00000184445 E075 56.4122296 0.0009126363 8.043664e-08 3.055926e-06 12 122613626 122613703 78 + 1.621 1.885 0.895
ENSG00000184445 E076 51.3667446 0.0007336989 4.269979e-04 4.995802e-03 12 122613704 122613761 58 + 1.615 1.798 0.622
ENSG00000184445 E077 61.3493466 0.0005867553 1.017207e-07 3.767615e-06 12 122614991 122615086 96 + 1.667 1.916 0.841
ENSG00000184445 E078 44.8278768 0.0008394476 2.544197e-06 6.436217e-05 12 122615470 122615526 57 + 1.530 1.787 0.873
ENSG00000184445 E079 0.0000000       12 122617407 122617501 95 +      
ENSG00000184445 E080 51.1521877 0.0017953197 1.439115e-07 5.145153e-06 12 122618343 122618397 55 + 1.572 1.855 0.958
ENSG00000184445 E081 61.3155204 0.0008187229 2.810575e-05 5.096095e-04 12 122618482 122618545 64 + 1.684 1.885 0.681
ENSG00000184445 E082 0.8288081 0.0219200340 1.450770e-01   12 122620042 122620478 437 + 0.147 0.406 1.938
ENSG00000184445 E083 88.9932632 0.0005773728 1.260274e-10 8.739222e-09 12 122620479 122620608 130 + 1.820 2.074 0.854
ENSG00000184445 E084 60.8114775 0.0076781872 6.700421e-07 2.005438e-05 12 122621881 122621970 90 + 1.632 1.941 1.044
ENSG00000184445 E085 62.1731187 0.0109186227 1.099607e-05 2.278690e-04 12 122622462 122622607 146 + 1.644 1.948 1.024
ENSG00000184445 E086 43.1226538 0.0015256873 2.257506e-07 7.665997e-06 12 122624598 122624688 91 + 1.493 1.788 1.004
ENSG00000184445 E087 32.5298431 0.0011325695 1.880860e-08 8.309400e-07 12 122626205 122626396 192 + 1.350 1.703 1.208