ENSG00000184007

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000457805 ENSG00000184007 HEK293_OSMI2_6hA HEK293_TMG_6hB PTP4A2 protein_coding protein_coding 157.2186 78.83451 241.2196 18.22844 11.25713 1.613325 28.428967 3.184006 54.324646 1.861439 2.872597 4.0884334 0.15851250 0.03273333 0.22586667 0.193133333 3.224523e-01 2.826831e-53 FALSE TRUE
ENST00000528840 ENSG00000184007 HEK293_OSMI2_6hA HEK293_TMG_6hB PTP4A2 protein_coding processed_transcript 157.2186 78.83451 241.2196 18.22844 11.25713 1.613325 10.633684 0.000000 12.995036 0.000000 6.506487 10.3448546 0.05915000 0.00000000 0.05550000 0.055500000 3.957785e-01 2.826831e-53   FALSE
ENST00000529477 ENSG00000184007 HEK293_OSMI2_6hA HEK293_TMG_6hB PTP4A2 protein_coding processed_transcript 157.2186 78.83451 241.2196 18.22844 11.25713 1.613325 15.283671 0.000000 53.353458 0.000000 3.960195 12.3816364 0.07765833 0.00000000 0.22106667 0.221066667 2.826831e-53 2.826831e-53   FALSE
ENST00000602683 ENSG00000184007 HEK293_OSMI2_6hA HEK293_TMG_6hB PTP4A2 protein_coding protein_coding 157.2186 78.83451 241.2196 18.22844 11.25713 1.613325 19.288976 12.046228 24.890710 2.322116 1.327345 1.0464083 0.12518750 0.15793333 0.10323333 -0.054700000 9.752326e-02 2.826831e-53 FALSE TRUE
ENST00000602725 ENSG00000184007 HEK293_OSMI2_6hA HEK293_TMG_6hB PTP4A2 protein_coding protein_coding 157.2186 78.83451 241.2196 18.22844 11.25713 1.613325 31.735706 18.474545 58.180826 5.033318 3.972559 1.6544722 0.22407917 0.23163333 0.24070000 0.009066667 9.621266e-01 2.826831e-53 FALSE TRUE
ENST00000647444 ENSG00000184007 HEK293_OSMI2_6hA HEK293_TMG_6hB PTP4A2 protein_coding protein_coding 157.2186 78.83451 241.2196 18.22844 11.25713 1.613325 29.954887 10.697072 18.406607 2.053292 1.621321 0.7824434 0.18012917 0.13953333 0.07723333 -0.062300000 7.130902e-02 2.826831e-53 FALSE TRUE
MSTRG.747.5 ENSG00000184007 HEK293_OSMI2_6hA HEK293_TMG_6hB PTP4A2 protein_coding   157.2186 78.83451 241.2196 18.22844 11.25713 1.613325 9.615138 23.012748 7.031519 3.637150 7.031519 -1.7091014 0.09719583 0.31073333 0.02766667 -0.283066667 7.811300e-02 2.826831e-53 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000184007 E001 1692.1264847 2.050271585 0.641102377 0.79759367 1 31906421 31908262 1842 - 3.209 3.233 0.079
ENSG00000184007 E002 360.8734384 1.562369786 0.624720633 0.78717229 1 31908263 31908533 271 - 2.553 2.541 -0.042
ENSG00000184007 E003 170.6012600 1.325902471 0.666518815 0.81399790 1 31908534 31908585 52 - 2.246 2.188 -0.194
ENSG00000184007 E004 203.2748683 1.381885598 0.648651038 0.80265131 1 31908586 31908652 67 - 2.316 2.273 -0.143
ENSG00000184007 E005 123.6902270 1.204608438 0.633411098 0.79255375 1 31908653 31908657 5 - 2.103 2.058 -0.150
ENSG00000184007 E006 334.2648113 1.525712430 0.584722274 0.76015686 1 31908658 31908707 50 - 2.505 2.531 0.087
ENSG00000184007 E007 662.4450362 1.732660808 0.556910565 0.74113433 1 31908708 31908838 131 - 2.782 2.854 0.241
ENSG00000184007 E008 796.3238518 1.776603820 0.520016887 0.71499796 1 31908839 31908960 122 - 2.842 2.959 0.389
ENSG00000184007 E009 505.3368795 0.062204470 0.120259728 0.31626112 1 31910038 31910068 31 - 2.650 2.756 0.354
ENSG00000184007 E010 548.2956187 0.006378444 0.008038192 0.04948595 1 31910069 31910112 44 - 2.696 2.781 0.284
ENSG00000184007 E011 4.3176848 0.092636811 0.335693871 0.57417656 1 31910113 31911280 1168 - 0.638 0.822 0.752
ENSG00000184007 E012 959.9258412 0.009685453 0.976369206 0.98995397 1 31911696 31911826 131 - 2.969 2.979 0.032
ENSG00000184007 E013 1.5251554 0.014329413 0.698440587 0.83457851 1 31912981 31913023 43 - 0.358 0.420 0.346
ENSG00000184007 E014 0.9003845 0.016310215 0.265313766   1 31913787 31913843 57 - 0.358 0.148 -1.658
ENSG00000184007 E015 3.7934764 0.084953298 0.542781106 0.73107385 1 31915540 31915894 355 - 0.710 0.587 -0.529
ENSG00000184007 E016 544.6576702 0.030787209 0.332269854 0.57107210 1 31915895 31915987 93 - 2.751 2.686 -0.218
ENSG00000184007 E017 524.3405978 0.026230893 0.143364129 0.35250082 1 31918970 31918999 30 - 2.747 2.646 -0.338
ENSG00000184007 E018 774.4970548 0.029994838 0.259887471 0.49890448 1 31919000 31919093 94 - 2.907 2.833 -0.245
ENSG00000184007 E019 497.3963683 0.028658645 0.272685450 0.51252159 1 31919094 31919129 36 - 2.714 2.643 -0.238
ENSG00000184007 E020 554.4296082 0.030410740 0.486027324 0.69124926 1 31919130 31919228 99 - 2.749 2.711 -0.125
ENSG00000184007 E021 286.1310152 0.031385431 0.982656176 0.99310933 1 31919229 31919243 15 - 2.439 2.462 0.076
ENSG00000184007 E022 260.1920238 0.034134850 0.900374160 0.95205156 1 31919244 31919246 3 - 2.403 2.413 0.033
ENSG00000184007 E023 247.0226532 0.032628178 0.926026862 0.96512656 1 31919247 31919259 13 - 2.380 2.392 0.040
ENSG00000184007 E024 742.5862888 0.041220301 0.407168247 0.63386593 1 31919260 31919423 164 - 2.883 2.825 -0.192
ENSG00000184007 E025 761.2626354 0.038843475 0.279334145 0.51944595 1 31919424 31919562 139 - 2.903 2.819 -0.277
ENSG00000184007 E026 302.8269541 0.028543773 0.071398658 0.22758952 1 31919563 31919568 6 - 2.521 2.384 -0.457
ENSG00000184007 E027 399.1597720 0.038318544 0.163902299 0.38247699 1 31919569 31919658 90 - 2.636 2.514 -0.405
ENSG00000184007 E028 0.5365243 0.026299118 0.321894960   1 31924018 31924165 148 - 0.099 0.259 1.668
ENSG00000184007 E029 0.4820342 0.021768165 0.195434037   1 31930039 31930334 296 - 0.248 0.000 -12.755
ENSG00000184007 E030 4.0590713 0.064489152 0.225398073 0.45980416 1 31930933 31931142 210 - 0.584 0.803 0.917
ENSG00000184007 E031 0.1426347 0.030763712 0.751948225   1 31932672 31932700 29 - 0.099 0.000 -11.168
ENSG00000184007 E032 1.7194471 0.081342626 0.062145907 0.20762944 1 31935589 31935659 71 - 0.247 0.590 1.915
ENSG00000184007 E033 0.1723744 0.098770454 0.312670180   1 31937755 31937777 23 - 0.000 0.148 12.466
ENSG00000184007 E034 0.1723744 0.098770454 0.312670180   1 31937778 31937841 64 - 0.000 0.148 12.466
ENSG00000184007 E035 0.7614362 0.874423682 0.829707323   1 31937842 31937986 145 - 0.186 0.276 0.729
ENSG00000184007 E036 214.6620571 0.038506365 0.952982789 0.97845263 1 31937987 31938059 73 - 2.316 2.335 0.065
ENSG00000184007 E037 72.5419319 0.084840192 0.599931316 0.77017149 1 31938060 31938118 59 - 1.822 1.904 0.275
ENSG00000184007 E038 55.0500419 0.137814342 0.092601176 0.26858311 1 31938119 31938262 144 - 1.580 1.907 1.108
ENSG00000184007 E039 34.6310880 0.125199170 0.049855428 0.17930111 1 31938263 31938368 106 - 1.356 1.729 1.278
ENSG00000184007 E040 0.0000000       1 31942529 31942576 48 -      
ENSG00000184007 E041 0.3032425 0.025045493 0.101549384   1 31944593 31944856 264 - 0.000 0.258 13.462