ENSG00000184005

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328299 ENSG00000184005 HEK293_OSMI2_6hA HEK293_TMG_6hB ST6GALNAC3 protein_coding protein_coding 4.28785 2.115379 6.874864 0.6369623 0.5037474 1.695708 0.9734365 0.19738128 2.0642785 0.02457895 0.02389907 3.322252 0.19504583 0.1119333 0.30340000 0.19146667 5.305225e-03 1.091446e-07 FALSE TRUE
ENST00000464140 ENSG00000184005 HEK293_OSMI2_6hA HEK293_TMG_6hB ST6GALNAC3 protein_coding processed_transcript 4.28785 2.115379 6.874864 0.6369623 0.5037474 1.695708 0.2665870 0.00000000 0.2098299 0.00000000 0.07076894 4.458316 0.05685833 0.0000000 0.03226667 0.03226667 2.383479e-01 1.091446e-07 FALSE TRUE
ENST00000621530 ENSG00000184005 HEK293_OSMI2_6hA HEK293_TMG_6hB ST6GALNAC3 protein_coding protein_coding 4.28785 2.115379 6.874864 0.6369623 0.5037474 1.695708 1.0697600 0.06140115 2.6964874 0.06140115 0.82291447 5.244331 0.19590417 0.0719000 0.37826667 0.30636667 2.165312e-01 1.091446e-07 FALSE FALSE
MSTRG.1431.2 ENSG00000184005 HEK293_OSMI2_6hA HEK293_TMG_6hB ST6GALNAC3 protein_coding   4.28785 2.115379 6.874864 0.6369623 0.5037474 1.695708 1.2918168 1.85659673 0.3687721 0.67323275 0.09491554 -2.301008 0.42885833 0.8162000 0.05213333 -0.76406667 1.091446e-07 1.091446e-07   FALSE
MSTRG.1431.4 ENSG00000184005 HEK293_OSMI2_6hA HEK293_TMG_6hB ST6GALNAC3 protein_coding   4.28785 2.115379 6.874864 0.6369623 0.5037474 1.695708 0.6862493 0.00000000 1.5354956 0.00000000 0.39658112 7.271926 0.12335000 0.0000000 0.23393333 0.23393333 2.795972e-04 1.091446e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000184005 E001 7.0003994 0.0056512017 4.128249e-07 1.309925e-05 1 76074746 76074772 27 + 0.579 1.255 2.603
ENSG00000184005 E002 12.4383906 0.0065197246 2.508156e-09 1.350484e-07 1 76074773 76074884 112 + 0.803 1.458 2.371
ENSG00000184005 E003 4.7343227 0.1398945540 7.660331e-09 3.692593e-07 1 76152247 76152392 146 + 0.167 1.374 5.600
ENSG00000184005 E004 3.7219891 0.0107459145 2.450726e-15 3.907884e-13 1 76153378 76153528 151 + 0.130 1.275 5.673
ENSG00000184005 E005 0.0000000       1 76313800 76313804 5 +      
ENSG00000184005 E006 11.6503258 0.0192023088 9.400248e-01 9.722399e-01 1 76313805 76313912 108 + 0.931 0.956 0.092
ENSG00000184005 E007 16.3212556 0.0029453837 3.471588e-01 5.846676e-01 1 76313913 76313999 87 + 1.073 0.997 -0.281
ENSG00000184005 E008 43.7488028 0.0028639008 8.088257e-02 2.465753e-01 1 76412008 76412417 410 + 1.479 1.383 -0.331
ENSG00000184005 E009 0.1779838 0.0348979299 7.981139e-01   1 76412997 76413003 7 + 0.048 0.001 -6.286
ENSG00000184005 E010 1.1774014 0.0425782491 3.897664e-01   1 76576846 76577209 364 + 0.260 0.001 -8.876
ENSG00000184005 E011 16.7526059 0.0029170579 2.016647e-02 9.646857e-02 1 76627452 76627559 108 + 1.091 0.803 -1.080
ENSG00000184005 E012 55.7695482 0.0113215503 3.465503e-04 4.204259e-03 1 76628620 76629190 571 + 1.593 1.314 -0.964
ENSG00000184005 E013 125.3444598 0.0004898634 5.763340e-06 1.304301e-04 1 76629191 76634127 4937 + 1.926 1.784 -0.480
ENSG00000184005 E014 2.8535773 0.0813424604 5.848362e-01 7.602060e-01 1 76634128 76634603 476 + 0.423 0.567 0.707