ENSG00000183955

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000402868 ENSG00000183955 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT5A protein_coding protein_coding 51.23124 46.86963 50.95757 2.536372 2.094174 0.1206185 10.663601 12.286801 9.177544 1.3446282 1.1483155 -0.4205318 0.21353333 0.26176667 0.18266667 -0.07910000 5.102503e-01 1.491282e-09 FALSE TRUE
ENST00000437519 ENSG00000183955 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT5A protein_coding nonsense_mediated_decay 51.23124 46.86963 50.95757 2.536372 2.094174 0.1206185 22.301129 22.501646 20.542874 3.1325166 2.1814005 -0.1313314 0.45035833 0.47556667 0.40090000 -0.07466667 7.286676e-01 1.491282e-09 FALSE TRUE
ENST00000461103 ENSG00000183955 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT5A protein_coding retained_intron 51.23124 46.86963 50.95757 2.536372 2.094174 0.1206185 1.941278 2.432091 0.000000 0.9269555 0.0000000 -7.9319733 0.03518750 0.05023333 0.00000000 -0.05023333 1.491282e-09 1.491282e-09 FALSE FALSE
ENST00000478781 ENSG00000183955 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT5A protein_coding processed_transcript 51.23124 46.86963 50.95757 2.536372 2.094174 0.1206185 3.388512 2.230308 4.208388 1.1972768 0.3511656 0.9129945 0.05637083 0.04736667 0.08316667 0.03580000 8.176576e-01 1.491282e-09 FALSE FALSE
ENST00000485469 ENSG00000183955 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT5A protein_coding processed_transcript 51.23124 46.86963 50.95757 2.536372 2.094174 0.1206185 8.974115 2.183846 15.303812 2.1838461 1.6260207 2.8032992 0.15614583 0.05180000 0.29883333 0.24703333 1.386703e-01 1.491282e-09 FALSE FALSE
ENST00000537270 ENSG00000183955 HEK293_OSMI2_6hA HEK293_TMG_6hB KMT5A protein_coding processed_transcript 51.23124 46.86963 50.95757 2.536372 2.094174 0.1206185 2.322686 3.436114 1.407329 0.7507573 0.3034549 -1.2817958 0.05287500 0.07530000 0.02816667 -0.04713333 2.362906e-01 1.491282e-09   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000183955 E001 9.0375505 0.0082354299 6.776121e-01 0.821226520 12 123384132 123384165 34 + 1.005 0.982 -0.086
ENSG00000183955 E002 16.9940144 0.0019235555 1.870297e-01 0.413088231 12 123384166 123384172 7 + 1.172 1.310 0.485
ENSG00000183955 E003 33.2857099 0.0012375249 5.022116e-01 0.702298126 12 123384173 123384208 36 + 1.495 1.564 0.235
ENSG00000183955 E004 15.7120325 0.0901600157 3.438198e-01 0.581466124 12 123388442 123388757 316 + 1.097 1.290 0.686
ENSG00000183955 E005 0.9418051 0.4197985118 1.257880e-01   12 123388900 123388950 51 + 0.000 0.401 12.211
ENSG00000183955 E006 1.9537586 0.0776374585 2.323891e-03 0.019209060 12 123388951 123389008 58 + 0.000 0.623 13.866
ENSG00000183955 E007 26.2253352 0.0248566012 3.945690e-01 0.624008764 12 123389009 123389182 174 + 1.363 1.469 0.365
ENSG00000183955 E008 2.5906035 0.0257220105 1.600493e-04 0.002219323 12 123389271 123389432 162 + 0.000 0.725 14.740
ENSG00000183955 E009 19.2996492 0.0018378369 2.770954e-04 0.003499715 12 123389433 123389436 4 + 1.090 1.421 1.165
ENSG00000183955 E010 24.7452374 0.0016166837 9.852007e-05 0.001476697 12 123389437 123389482 46 + 1.203 1.521 1.106
ENSG00000183955 E011 49.8770262 0.0053982126 5.126443e-03 0.035276464 12 123389483 123389554 72 + 1.575 1.775 0.679
ENSG00000183955 E012 1.1715316 0.3901193128 8.057316e-01   12 123390042 123390150 109 + 0.322 0.337 0.095
ENSG00000183955 E013 176.0709891 0.0003150562 1.764532e-02 0.087797561 12 123390630 123390710 81 + 2.265 2.229 -0.122
ENSG00000183955 E014 247.8275111 0.0002526188 5.746046e-04 0.006350862 12 123390711 123390786 76 + 2.421 2.370 -0.169
ENSG00000183955 E015 3.5998822 0.0067834567 1.524789e-01 0.365931485 12 123390787 123391304 518 + 0.504 0.746 1.060
ENSG00000183955 E016 1.4330802 0.0130311074 2.127155e-01 0.444920444 12 123391380 123391430 51 + 0.238 0.477 1.452
ENSG00000183955 E017 464.7841196 0.0009528249 8.192643e-05 0.001266775 12 123395047 123395266 220 + 2.695 2.641 -0.180
ENSG00000183955 E018 353.1922121 0.0004192054 7.884662e-05 0.001226300 12 123396345 123396432 88 + 2.575 2.523 -0.173
ENSG00000183955 E019 276.6020959 0.0002128533 4.832945e-02 0.175763911 12 123403573 123403632 60 + 2.448 2.434 -0.049
ENSG00000183955 E020 350.2203482 0.0003736004 2.409098e-02 0.109352430 12 123404884 123405074 191 + 2.552 2.534 -0.059
ENSG00000183955 E021 1501.1651469 0.0020692703 9.897853e-05 0.001481738 12 123407493 123409638 2146 + 3.123 3.208 0.285