ENSG00000183506

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000476537 ENSG00000183506 HEK293_OSMI2_6hA HEK293_TMG_6hB PI4KAP2 transcribed_unitary_pseudogene retained_intron 20.25037 26.4001 19.00054 3.242639 0.4630092 -0.4742904 1.833438 2.236882 1.735819 1.1686100 0.79747765 -0.364020025 0.08818750 0.07566667 0.09046667 0.01480000 0.9400498967 0.0003848274   FALSE
ENST00000477296 ENSG00000183506 HEK293_OSMI2_6hA HEK293_TMG_6hB PI4KAP2 transcribed_unitary_pseudogene retained_intron 20.25037 26.4001 19.00054 3.242639 0.4630092 -0.4742904 3.239595 3.906569 3.540075 0.7973576 0.09690476 -0.141740721 0.15742500 0.14570000 0.18650000 0.04080000 0.5692970859 0.0003848274 TRUE FALSE
ENST00000480319 ENSG00000183506 HEK293_OSMI2_6hA HEK293_TMG_6hB PI4KAP2 transcribed_unitary_pseudogene retained_intron 20.25037 26.4001 19.00054 3.242639 0.4630092 -0.4742904 5.689854 7.135906 7.183272 1.7208355 0.23850295 0.009531188 0.28010833 0.26330000 0.37850000 0.11520000 0.2848128164 0.0003848274 FALSE TRUE
MSTRG.21712.14 ENSG00000183506 HEK293_OSMI2_6hA HEK293_TMG_6hB PI4KAP2 transcribed_unitary_pseudogene   20.25037 26.4001 19.00054 3.242639 0.4630092 -0.4742904 0.457887 1.274161 0.000000 0.5312995 0.00000000 -7.004682792 0.02348333 0.05516667 0.00000000 -0.05516667 0.0003848274 0.0003848274 FALSE TRUE
MSTRG.21712.20 ENSG00000183506 HEK293_OSMI2_6hA HEK293_TMG_6hB PI4KAP2 transcribed_unitary_pseudogene   20.25037 26.4001 19.00054 3.242639 0.4630092 -0.4742904 3.287340 4.472245 2.516863 0.6990341 0.38328210 -0.826873866 0.16183750 0.16786667 0.13283333 -0.03503333 0.7292467067 0.0003848274 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000183506 E001 0.3447487 0.2256985202 0.4917823652   22 21472540 21472541 2 - 0.000 0.168 9.470
ENSG00000183506 E002 0.3447487 0.2256985202 0.4917823652   22 21472542 21472682 141 - 0.000 0.168 11.528
ENSG00000183506 E003 0.0000000       22 21473000 21473008 9 -      
ENSG00000183506 E004 0.0000000       22 21473009 21473010 2 -      
ENSG00000183506 E005 0.0000000       22 21473011 21473019 9 -      
ENSG00000183506 E006 0.0000000       22 21473020 21473020 1 -      
ENSG00000183506 E007 0.1723744 0.0306699668 0.8514540601   22 21473021 21473022 2 - 0.000 0.091 11.241
ENSG00000183506 E008 0.1723744 0.0306699668 0.8514540601   22 21473023 21473034 12 - 0.000 0.091 11.241
ENSG00000183506 E009 0.1723744 0.0306699668 0.8514540601   22 21473035 21473058 24 - 0.000 0.091 11.241
ENSG00000183506 E010 0.1723744 0.0306699668 0.8514540601   22 21473059 21473075 17 - 0.000 0.091 11.241
ENSG00000183506 E011 0.1723744 0.0306699668 0.8514540601   22 21473076 21473098 23 - 0.000 0.091 11.241
ENSG00000183506 E012 0.0000000       22 21473099 21473100 2 -      
ENSG00000183506 E013 0.0000000       22 21473101 21473135 35 -      
ENSG00000183506 E014 12.3420709 0.0028714989 0.3930623537 0.622845995 22 21473136 21473405 270 - 1.157 1.062 -0.342
ENSG00000183506 E015 20.6788206 0.0045438472 0.4863313763 0.691484802 22 21474597 21474680 84 - 1.349 1.281 -0.240
ENSG00000183506 E016 18.7004945 0.0037358012 0.5864420799 0.761237470 22 21474681 21474800 120 - 1.242 1.280 0.132
ENSG00000183506 E017 21.3939855 0.0596377756 0.1945140537 0.422746134 22 21475211 21475300 90 - 1.438 1.245 -0.672
ENSG00000183506 E018 9.6725933 0.0096173498 0.8830653004 0.942866475 22 21475301 21475991 691 - 0.996 1.006 0.039
ENSG00000183506 E019 9.1405507 0.7129166909 0.0759929388 0.236751951 22 21475992 21476001 10 - 1.217 0.775 -1.642
ENSG00000183506 E020 26.0105113 0.0460165312 0.0087983270 0.052939252 22 21476002 21476160 159 - 1.587 1.262 -1.123
ENSG00000183506 E021 0.6847684 0.0186756670 0.1087702868   22 21476161 21476223 63 - 0.368 0.091 -2.512
ENSG00000183506 E022 17.2115670 0.0021758365 0.3026876159 0.543272094 22 21476224 21476643 420 - 1.183 1.263 0.282
ENSG00000183506 E023 35.2373452 0.0013743274 0.8831077470 0.942882155 22 21476644 21476741 98 - 1.542 1.540 -0.007
ENSG00000183506 E024 38.1123501 0.0010621966 0.3493352456 0.586657563 22 21476742 21476764 23 - 1.613 1.548 -0.222
ENSG00000183506 E025 56.3087770 0.0039641508 0.0005271416 0.005925388 22 21476765 21477217 453 - 1.851 1.656 -0.661
ENSG00000183506 E026 7.3927814 0.0079517265 0.8298708374 0.913707479 22 21477380 21477412 33 - 0.885 0.904 0.072
ENSG00000183506 E027 27.8760151 0.0063108191 0.6320549278 0.791724796 22 21477413 21477789 377 - 1.463 1.421 -0.146
ENSG00000183506 E028 57.0141691 0.0008111917 0.4267900928 0.648600138 22 21477790 21477915 126 - 1.721 1.750 0.096
ENSG00000183506 E029 27.1211085 0.0015488016 0.0995379858 0.280924201 22 21477997 21478101 105 - 1.350 1.456 0.370
ENSG00000183506 E030 1.0354865 0.1927715438 0.8909798411   22 21478102 21478161 60 - 0.274 0.294 0.135
ENSG00000183506 E031 1.7294959 0.1470990390 0.8945581861 0.948992109 22 21478162 21478584 423 - 0.442 0.421 -0.110
ENSG00000183506 E032 60.4711814 0.0106672362 0.0282473523 0.122010677 22 21478585 21478694 110 - 1.674 1.808 0.455
ENSG00000183506 E033 100.0214596 0.0014409775 0.4078632688 0.634355973 22 21479759 21479829 71 - 1.969 1.991 0.072
ENSG00000183506 E034 138.0547649 0.0005074998 0.7634448278 0.874738089 22 21479930 21480002 73 - 2.122 2.119 -0.007
ENSG00000183506 E035 97.4380638 0.0004440743 0.5438467444 0.731805355 22 21483020 21483090 71 - 1.990 1.956 -0.113
ENSG00000183506 E036 103.1376624 0.0004050816 0.0438764311 0.164806405 22 21484005 21484134 130 - 1.950 2.012 0.207
ENSG00000183506 E037 88.2427259 0.0005427382 0.2664886807 0.505980493 22 21486800 21486927 128 - 1.904 1.936 0.107
ENSG00000183506 E038 5.9485548 0.0050074176 0.8943110594 0.948848490 22 21486928 21486975 48 - 0.832 0.805 -0.105
ENSG00000183506 E039 59.1711557 0.0007309198 0.0271818048 0.118836773 22 21487565 21487672 108 - 1.691 1.788 0.327
ENSG00000183506 E040 61.4890613 0.0007913390 0.0949079300 0.272830137 22 21487872 21488023 152 - 1.729 1.797 0.232
ENSG00000183506 E041 25.0861365 0.0014286920 0.6181554181 0.782531091 22 21488224 21488337 114 - 1.375 1.400 0.086
ENSG00000183506 E042 18.9366414 0.0020563885 0.8960457268 0.949822565 22 21488338 21488381 44 - 1.285 1.263 -0.076
ENSG00000183506 E043 12.9622835 0.0061118139 0.9258235097 0.965077531 22 21488382 21488410 29 - 1.130 1.112 -0.065
ENSG00000183506 E044 20.9901123 0.0420039084 0.1857988609 0.411617094 22 21488411 21488792 382 - 1.408 1.267 -0.491
ENSG00000183506 E045 56.5108750 0.0108974268 0.0159819614 0.081747677 22 21488793 21490611 1819 - 1.837 1.675 -0.545
ENSG00000183506 E046 1.1124618 0.0143057317 0.0283140836   22 21491976 21491993 18 - 0.000 0.421 14.011
ENSG00000183506 E047 13.6785012 0.0159637257 0.1715278285 0.392536794 22 21491994 21492094 101 - 1.051 1.189 0.494
ENSG00000183506 E048 0.1308682 0.0312403711 0.8513527645   22 21494880 21495023 144 - 0.000 0.091 11.234
ENSG00000183506 E049 0.0000000       22 21514130 21514133 4 -      
ENSG00000183506 E050 0.0000000       22 21514134 21514255 122 -      
ENSG00000183506 E051 4.5216837 0.0072724247 0.1025280830 0.286271853 22 21517325 21517533 209 - 0.565 0.804 1.006