ENSG00000183250

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330551 ENSG00000183250 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01547 lncRNA lncRNA 7.573523 13.01154 2.881114 1.701651 0.1729226 -2.171203 0.6190103 1.606108 0.1679928 0.38364689 0.16799284 -3.1826329 0.07120417 0.12710000 0.05833333 -0.06876667 5.205017e-01 3.183928e-05 FALSE TRUE
ENST00000397841 ENSG00000183250 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01547 lncRNA lncRNA 7.573523 13.01154 2.881114 1.701651 0.1729226 -2.171203 3.4484484 6.026229 1.5205458 0.71650760 0.18226069 -1.9796013 0.45958333 0.46453333 0.52530000 0.06076667 7.714361e-01 3.183928e-05 FALSE TRUE
ENST00000654166 ENSG00000183250 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01547 lncRNA lncRNA 7.573523 13.01154 2.881114 1.701651 0.1729226 -2.171203 0.5274604 0.000000 0.0000000 0.00000000 0.00000000 0.0000000 0.07485000 0.00000000 0.00000000 0.00000000   3.183928e-05 FALSE TRUE
ENST00000660377 ENSG00000183250 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01547 lncRNA lncRNA 7.573523 13.01154 2.881114 1.701651 0.1729226 -2.171203 0.8442739 1.168830 0.0000000 0.88342809 0.00000000 -6.8812114 0.09358750 0.07590000 0.00000000 -0.07590000 5.821550e-01 3.183928e-05 FALSE TRUE
ENST00000663249 ENSG00000183250 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01547 lncRNA lncRNA 7.573523 13.01154 2.881114 1.701651 0.1729226 -2.171203 0.4311353 1.261102 0.3635309 0.23665858 0.18433846 -1.7667808 0.06157917 0.10426667 0.12623333 0.02196667 1.000000e+00 3.183928e-05 FALSE TRUE
ENST00000667826 ENSG00000183250 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01547 lncRNA lncRNA 7.573523 13.01154 2.881114 1.701651 0.1729226 -2.171203 0.9683334 1.206956 0.6576920 0.11757527 0.06528548 -0.8660223 0.15068750 0.09453333 0.22783333 0.13330000 9.230576e-03 3.183928e-05 FALSE TRUE
MSTRG.21476.13 ENSG00000183250 HEK293_OSMI2_6hA HEK293_TMG_6hB LINC01547 lncRNA   7.573523 13.01154 2.881114 1.701651 0.1729226 -2.171203 0.3220833 1.076729 0.0000000 0.02403645 0.00000000 -6.7638478 0.03218333 0.08503333 0.00000000 -0.08503333 3.183928e-05 3.183928e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000183250 E001 50.865773 0.0008719138 0.0513746019 0.183009020 21 44932814 44933306 493 - 1.484 1.619 0.462
ENSG00000183250 E002 16.048922 0.0021829898 0.6234419886 0.786188759 21 44933307 44933314 8 - 1.156 1.109 -0.169
ENSG00000183250 E003 149.682949 0.0015162645 0.8967773603 0.950192710 21 44933315 44934073 759 - 2.054 2.064 0.034
ENSG00000183250 E004 52.761166 0.0100736295 0.6334049575 0.792551908 21 44934074 44934228 155 - 1.640 1.612 -0.095
ENSG00000183250 E005 48.924750 0.0008177535 0.0327205948 0.135275448 21 44934229 44934368 140 - 1.681 1.558 -0.421
ENSG00000183250 E006 29.255379 0.0014663991 0.0471291930 0.172845777 21 44934369 44934724 356 - 1.484 1.337 -0.508
ENSG00000183250 E007 8.678544 0.0126760929 0.0691881550 0.223171191 21 44934725 44934729 5 - 1.062 0.830 -0.868
ENSG00000183250 E008 37.393237 0.0013189225 0.4538654658 0.668620320 21 44934730 44934933 204 - 1.419 1.482 0.214
ENSG00000183250 E009 58.516803 0.0020339583 0.2018668796 0.431981742 21 44934934 44935004 71 - 1.590 1.676 0.294
ENSG00000183250 E010 65.703251 0.0007290915 0.0663628768 0.216881315 21 44935005 44935093 89 - 1.613 1.724 0.379
ENSG00000183250 E011 35.368980 0.0016147815 0.4059553356 0.633014442 21 44935094 44935096 3 - 1.383 1.452 0.237
ENSG00000183250 E012 106.769465 0.0004356511 0.0230589851 0.106143334 21 44935627 44935890 264 - 1.826 1.933 0.360
ENSG00000183250 E013 14.889738 0.0109687819 0.0184454307 0.090517782 21 44937539 44937682 144 - 1.284 1.029 -0.912
ENSG00000183250 E014 22.924646 0.0029112203 0.0013936731 0.012852444 21 44937683 44938443 761 - 1.464 1.200 -0.920
ENSG00000183250 E015 20.631787 0.0021209655 0.9931730598 0.998269541 21 44938444 44938607 164 - 1.216 1.219 0.012
ENSG00000183250 E016 21.761369 0.0024336187 0.0221815825 0.103215226 21 44938608 44938760 153 - 1.395 1.200 -0.686
ENSG00000183250 E017 15.036339 0.0031761694 0.0002048747 0.002728583 21 44938761 44938835 75 - 1.357 1.002 -1.267
ENSG00000183250 E018 26.130726 0.0091291685 0.0667632705 0.217815282 21 44938836 44939050 215 - 1.442 1.279 -0.566
ENSG00000183250 E019 35.517816 0.0026540201 0.4949015338 0.697356068 21 44939051 44939592 542 - 1.484 1.435 -0.167
ENSG00000183250 E020 64.791472 0.0006044830 0.0100985568 0.058561752 21 44939593 44939769 177 - 1.566 1.725 0.542
ENSG00000183250 E021 40.591565 0.1413226661 0.1308618618 0.333158743 21 44939770 44939941 172 - 1.290 1.533 0.841