ENSG00000182985

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000537058 ENSG00000182985 HEK293_OSMI2_6hA HEK293_TMG_6hB CADM1 protein_coding protein_coding 34.65432 14.14975 51.81072 1.911352 2.541005 1.871733 3.8732169 0.2662830 6.036869 0.14165619 0.3625143 4.451970 0.07594167 0.02050000 0.1165000 0.09600000 1.887029e-01 2.52593e-20 FALSE TRUE
ENST00000542447 ENSG00000182985 HEK293_OSMI2_6hA HEK293_TMG_6hB CADM1 protein_coding protein_coding 34.65432 14.14975 51.81072 1.911352 2.541005 1.871733 14.8182083 5.7852929 22.297397 0.89270301 0.3114252 1.944569 0.43519583 0.40660000 0.4319333 0.02533333 8.776589e-01 2.52593e-20 FALSE TRUE
ENST00000545094 ENSG00000182985 HEK293_OSMI2_6hA HEK293_TMG_6hB CADM1 protein_coding protein_coding 34.65432 14.14975 51.81072 1.911352 2.541005 1.871733 3.8275115 0.8961854 6.889655 0.89618545 3.4744833 2.928646 0.07427917 0.05076667 0.1276000 0.07683333 6.908829e-01 2.52593e-20 FALSE FALSE
ENST00000616271 ENSG00000182985 HEK293_OSMI2_6hA HEK293_TMG_6hB CADM1 protein_coding protein_coding 34.65432 14.14975 51.81072 1.911352 2.541005 1.871733 0.6176432 1.4726312 0.000000 0.09980235 0.0000000 -7.212016 0.03817500 0.10846667 0.0000000 -0.10846667 2.525930e-20 2.52593e-20 FALSE TRUE
MSTRG.6350.10 ENSG00000182985 HEK293_OSMI2_6hA HEK293_TMG_6hB CADM1 protein_coding   34.65432 14.14975 51.81072 1.911352 2.541005 1.871733 10.1507632 4.9175492 14.040511 0.71636581 0.7063859 1.511680 0.32682083 0.35113333 0.2715667 -0.07956667 6.212683e-01 2.52593e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000182985 E001 0.0000000       11 115169218 115169235 18 -      
ENSG00000182985 E002 0.1308682 0.0310825325 1.455036e-01   11 115169236 115169588 353 - 0.000 0.195 11.567
ENSG00000182985 E003 1.2485298 0.0135972278 9.560851e-01   11 115169589 115169626 38 - 0.322 0.329 0.044
ENSG00000182985 E004 0.5470056 0.3120915692 3.589303e-01   11 115169627 115173624 3998 - 0.134 0.321 1.604
ENSG00000182985 E005 253.9205347 0.0002769989 1.565670e-01 3.716670e-01 11 115173625 115174306 682 - 2.333 2.363 0.102
ENSG00000182985 E006 512.5078692 0.0020273896 3.559429e-05 6.240169e-04 11 115174307 115175340 1034 - 2.671 2.557 -0.381
ENSG00000182985 E007 487.4515159 0.0001391197 2.874939e-15 4.545911e-13 11 115175341 115176326 986 - 2.659 2.501 -0.526
ENSG00000182985 E008 43.7993073 0.0008515399 1.503943e-02 7.823203e-02 11 115176327 115176329 3 - 1.624 1.460 -0.563
ENSG00000182985 E009 102.6470908 0.0004054081 1.152996e-02 6.451572e-02 11 115176330 115176407 78 - 1.979 1.867 -0.377
ENSG00000182985 E010 106.5137311 0.0006904852 4.446632e-01 6.618988e-01 11 115176408 115176466 59 - 1.977 1.941 -0.124
ENSG00000182985 E011 174.2282923 0.0008443621 4.579496e-01 6.717253e-01 11 115176467 115176592 126 - 2.177 2.196 0.064
ENSG00000182985 E012 140.1190495 0.0004340854 2.169916e-03 1.820390e-02 11 115178644 115178775 132 - 2.061 2.158 0.325
ENSG00000182985 E013 4.6840273 0.0446628950 4.099747e-04 4.827230e-03 11 115178776 115179111 336 - 0.478 1.034 2.288
ENSG00000182985 E014 0.7381610 0.0172671820 9.325064e-02   11 115190609 115190887 279 - 0.136 0.431 2.212
ENSG00000182985 E015 1.7067707 0.0468524065 1.016551e-02 5.883518e-02 11 115190888 115190941 54 - 0.239 0.695 2.432
ENSG00000182985 E016 0.4646582 0.0229748887 1.232445e-01   11 115190942 115191046 105 - 0.073 0.329 2.627
ENSG00000182985 E017 0.8866948 0.0172671820 9.488492e-03   11 115193838 115194110 273 - 0.073 0.515 3.631
ENSG00000182985 E018 9.5386053 0.0032714455 5.478724e-02 1.908619e-01 11 115198406 115198438 33 - 0.901 1.111 0.775
ENSG00000182985 E019 0.2735028 0.0261832626 4.036579e-01   11 115198439 115198440 2 - 0.073 0.195 1.628
ENSG00000182985 E020 0.0000000       11 115207302 115207307 6 -      
ENSG00000182985 E021 87.5719663 0.0005396056 2.141096e-04 2.831233e-03 11 115209574 115209657 84 - 1.844 1.991 0.497
ENSG00000182985 E022 0.1779838 0.0343138566 1.000000e+00   11 115214490 115214607 118 - 0.073 0.000 -12.343
ENSG00000182985 E023 114.1375285 0.0004409435 1.484502e-02 7.748656e-02 11 115214608 115214698 91 - 1.974 2.059 0.285
ENSG00000182985 E024 141.6113434 0.0003555443 1.728671e-01 3.942946e-01 11 115214699 115214780 82 - 2.081 2.121 0.135
ENSG00000182985 E025 127.7635573 0.0004581171 6.986672e-01 8.347589e-01 11 115217892 115217939 48 - 2.044 2.052 0.027
ENSG00000182985 E026 123.2103582 0.0003394768 9.780473e-01 9.907834e-01 11 115217940 115217991 52 - 2.032 2.028 -0.016
ENSG00000182985 E027 0.1426347 0.0315242936 1.000000e+00   11 115217992 115218144 153 - 0.073 0.000 -12.379
ENSG00000182985 E028 119.2379068 0.0004511235 9.604316e-02 2.747883e-01 11 115229113 115229155 43 - 2.003 2.059 0.186
ENSG00000182985 E029 112.1493470 0.0015560973 6.072043e-02 2.044314e-01 11 115229156 115229188 33 - 1.971 2.044 0.243
ENSG00000182985 E030 125.8934708 0.0004726773 1.086082e-01 2.967628e-01 11 115229189 115229219 31 - 2.028 2.080 0.174
ENSG00000182985 E031 198.7122677 0.0002518706 1.276783e-01 3.281877e-01 11 115229220 115229271 52 - 2.227 2.264 0.126
ENSG00000182985 E032 252.5799027 0.0002073532 2.081010e-02 9.870775e-02 11 115231353 115231439 87 - 2.327 2.379 0.174
ENSG00000182985 E033 210.0752360 0.0002965040 7.087594e-01 8.410085e-01 11 115231440 115231490 51 - 2.263 2.247 -0.055
ENSG00000182985 E034 277.0760466 0.0001873429 4.997477e-01 7.005674e-01 11 115238500 115238652 153 - 2.378 2.388 0.035
ENSG00000182985 E035 204.3279395 0.0003445026 3.261339e-01 5.653177e-01 11 115240274 115240420 147 - 2.245 2.267 0.074
ENSG00000182985 E036 0.3393995 0.0274424043 7.596371e-01   11 115240421 115240422 2 - 0.136 0.000 -13.435
ENSG00000182985 E037 0.1614157 0.0334695520 1.000000e+00   11 115240797 115240980 184 - 0.073 0.000 -12.353
ENSG00000182985 E038 0.0000000       11 115256832 115256891 60 -      
ENSG00000182985 E039 0.0000000       11 115287403 115287477 75 -      
ENSG00000182985 E040 0.0000000       11 115377307 115377362 56 -      
ENSG00000182985 E041 0.1614157 0.0334695520 1.000000e+00   11 115399084 115399513 430 - 0.073 0.000 -12.353
ENSG00000182985 E042 0.4842470 0.8054269936 8.369776e-01   11 115445761 115445836 76 - 0.192 0.000 -12.552
ENSG00000182985 E043 0.1614157 0.0334695520 1.000000e+00   11 115490814 115490858 45 - 0.073 0.000 -12.353
ENSG00000182985 E044 100.2514205 0.0005392542 1.429228e-02 7.549481e-02 11 115504271 115504523 253 - 1.920 2.011 0.306
ENSG00000182985 E045 0.6600180 0.0193874923 2.980856e-01   11 115504883 115504957 75 - 0.239 0.000 -14.557