ENSG00000182621

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338037 ENSG00000182621 HEK293_OSMI2_6hA HEK293_TMG_6hB PLCB1 protein_coding protein_coding 2.715791 2.441632 3.283089 1.117656 0.3150347 0.4256992 0.10736888 0.04843450 0.0000000 0.03109345 0.00000000 -2.5468203 0.04698750 0.105533333 0.00000000 -0.10553333 0.59878505 0.03953205 FALSE TRUE
ENST00000404098 ENSG00000182621 HEK293_OSMI2_6hA HEK293_TMG_6hB PLCB1 protein_coding protein_coding 2.715791 2.441632 3.283089 1.117656 0.3150347 0.4256992 0.03723631 0.06771772 0.0461425 0.05162904 0.02618279 -0.4691502 0.04442083 0.164366667 0.01316667 -0.15120000 0.97162305 0.03953205 FALSE TRUE
ENST00000612075 ENSG00000182621 HEK293_OSMI2_6hA HEK293_TMG_6hB PLCB1 protein_coding protein_coding 2.715791 2.441632 3.283089 1.117656 0.3150347 0.4256992 0.06588645 0.00000000 0.2149029 0.00000000 0.07633103 4.4912302 0.03950417 0.000000000 0.06660000 0.06660000 0.07109332 0.03953205 FALSE TRUE
ENST00000626966 ENSG00000182621 HEK293_OSMI2_6hA HEK293_TMG_6hB PLCB1 protein_coding protein_coding 2.715791 2.441632 3.283089 1.117656 0.3150347 0.4256992 0.22990387 0.02789117 0.7879951 0.02789117 0.42275876 4.3964462 0.07745417 0.009966667 0.22740000 0.21743333 0.57850664 0.03953205 FALSE TRUE
ENST00000628900 ENSG00000182621 HEK293_OSMI2_6hA HEK293_TMG_6hB PLCB1 protein_coding processed_transcript 2.715791 2.441632 3.283089 1.117656 0.3150347 0.4256992 0.17506046 0.00000000 0.1678005 0.00000000 0.16780052 4.1521877 0.07295417 0.000000000 0.05590000 0.05590000 0.94934079 0.03953205 FALSE TRUE
ENST00000629992 ENSG00000182621 HEK293_OSMI2_6hA HEK293_TMG_6hB PLCB1 protein_coding protein_coding 2.715791 2.441632 3.283089 1.117656 0.3150347 0.4256992 0.27162134 0.03984205 0.4409202 0.02626827 0.02354516 3.1774369 0.10655833 0.039166667 0.13770000 0.09853333 0.03953205 0.03953205 TRUE TRUE
ENST00000637422 ENSG00000182621 HEK293_OSMI2_6hA HEK293_TMG_6hB PLCB1 protein_coding protein_coding 2.715791 2.441632 3.283089 1.117656 0.3150347 0.4256992 0.40747899 1.67276065 0.0000000 0.88793076 0.00000000 -7.3946862 0.09834583 0.478866667 0.00000000 -0.47886667 0.07448024 0.03953205   FALSE
ENST00000637935 ENSG00000182621 HEK293_OSMI2_6hA HEK293_TMG_6hB PLCB1 protein_coding protein_coding 2.715791 2.441632 3.283089 1.117656 0.3150347 0.4256992 0.09687818 0.18005020 0.2738582 0.18005020 0.27385820 0.5787899 0.05417083 0.043133333 0.07000000 0.02686667 0.97447779 0.03953205   FALSE
MSTRG.20338.3 ENSG00000182621 HEK293_OSMI2_6hA HEK293_TMG_6hB PLCB1 protein_coding   2.715791 2.441632 3.283089 1.117656 0.3150347 0.4256992 0.60363519 0.16843479 1.0896382 0.16843479 0.34851537 2.6235601 0.19253750 0.060166667 0.35366667 0.29350000 0.34958133 0.03953205 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000182621 E001 0.0000000       20 8077251 8077304 54 +      
ENSG00000182621 E002 0.0000000       20 8114453 8114458 6 +      
ENSG00000182621 E003 0.8274031 0.017381563 1.000000000   20 8114459 8114506 48 + 0.210 0.223 0.113
ENSG00000182621 E004 1.8847775 0.027733956 0.770796966 0.87913266 20 8114507 8114573 67 + 0.406 0.369 -0.208
ENSG00000182621 E005 0.2027342 0.038057620 0.103483881   20 8132138 8132265 128 + 0.000 0.223 15.009
ENSG00000182621 E006 0.3336024 0.024441170 0.020171784   20 8132266 8132269 4 + 0.000 0.369 15.955
ENSG00000182621 E007 0.3336024 0.024441170 0.020171784   20 8132270 8132314 45 + 0.000 0.369 15.955
ENSG00000182621 E008 0.5059767 0.021768165 0.003701631   20 8132315 8132515 201 + 0.000 0.479 16.478
ENSG00000182621 E009 0.1723744 0.117657602 0.107333431   20 8132516 8132525 10 + 0.000 0.223 14.817
ENSG00000182621 E010 1.5059418 0.226298842 0.157503791 0.37295750 20 8132526 8132648 123 + 0.249 0.575 1.833
ENSG00000182621 E011 2.5870164 0.473537415 0.469548090 0.67970324 20 8132649 8132750 102 + 0.417 0.654 1.122
ENSG00000182621 E012 0.0000000       20 8141871 8141948 78 +      
ENSG00000182621 E013 2.9189240 0.014345623 0.718834592 0.84747005 20 8150294 8150299 6 + 0.523 0.479 -0.214
ENSG00000182621 E014 3.8114160 0.071032158 0.782641442 0.88619238 20 8150300 8150324 25 + 0.582 0.641 0.257
ENSG00000182621 E015 5.3413730 0.033460551 0.163516532 0.38197043 20 8150325 8150371 47 + 0.647 0.889 0.972
ENSG00000182621 E016 0.0000000       20 8150372 8150383 12 +      
ENSG00000182621 E017 0.0000000       20 8305674 8305685 12 +      
ENSG00000182621 E018 0.0000000       20 8305686 8305714 29 +      
ENSG00000182621 E019 0.0000000       20 8305715 8305933 219 +      
ENSG00000182621 E020 0.0000000       20 8306366 8306377 12 +      
ENSG00000182621 E021 0.0000000       20 8371080 8371381 302 +      
ENSG00000182621 E022 5.4499461 0.005108752 0.017132025 0.08593236 20 8371382 8371450 69 + 0.629 0.987 1.418
ENSG00000182621 E023 0.1779838 0.037201356 1.000000000   20 8371451 8372166 716 + 0.063 0.000 -12.406
ENSG00000182621 E024 0.0000000       20 8600715 8600725 11 +      
ENSG00000182621 E025 2.1567367 0.021380223 0.564837839 0.74667190 20 8600726 8600781 56 + 0.457 0.369 -0.478
ENSG00000182621 E026 0.0000000       20 8623876 8623921 46 +      
ENSG00000182621 E027 0.1426347 0.033721062 1.000000000   20 8625263 8625312 50 + 0.063 0.000 -12.405
ENSG00000182621 E028 0.0000000       20 8628288 8628293 6 +      
ENSG00000182621 E029 9.6847264 0.004435542 0.455335968 0.66975483 20 8628294 8628431 138 + 0.919 1.043 0.461
ENSG00000182621 E030 0.0000000       20 8628432 8628617 186 +      
ENSG00000182621 E031 8.7486328 0.003934712 0.830295763 0.91395060 20 8646102 8646181 80 + 0.894 0.956 0.234
ENSG00000182621 E032 7.7325433 0.004153406 0.491735628 0.69516127 20 8647900 8647953 54 + 0.867 0.803 -0.248
ENSG00000182621 E033 5.4353849 0.005771760 0.712654293 0.84342011 20 8649374 8649390 17 + 0.728 0.701 -0.113
ENSG00000182621 E034 4.7230896 0.005563001 0.327735889 0.56681237 20 8649391 8649393 3 + 0.702 0.566 -0.592
ENSG00000182621 E035 7.1580109 0.003843277 0.105740815 0.29189880 20 8649394 8649449 56 + 0.858 0.639 -0.890
ENSG00000182621 E036 0.9520415 0.328296777 0.051854392   20 8649450 8649989 540 + 0.117 0.567 3.124
ENSG00000182621 E037 2.6696943 0.009052428 0.357976446 0.59413643 20 8651413 8651627 215 + 0.522 0.369 -0.799
ENSG00000182621 E038 12.6445619 0.002516468 0.249748777 0.48758430 20 8651628 8653531 1904 + 1.057 0.956 -0.372
ENSG00000182621 E039 6.0900377 0.004736915 0.260678507 0.49968692 20 8657184 8657284 101 + 0.787 0.639 -0.612
ENSG00000182621 E040 7.3419641 0.003867627 0.206865404 0.43799251 20 8658538 8658620 83 + 0.858 0.701 -0.627
ENSG00000182621 E041 8.8898446 0.004016719 0.718269831 0.84713779 20 8658621 8658704 84 + 0.902 0.887 -0.058
ENSG00000182621 E042 9.0960457 0.017747342 0.673677328 0.81873360 20 8684932 8685078 147 + 0.918 0.887 -0.115
ENSG00000182621 E043 6.8178583 0.026752380 0.492085936 0.69541075 20 8697626 8697783 158 + 0.785 0.921 0.526
ENSG00000182621 E044 5.0212254 0.042419011 0.954302341 0.97904022 20 8708670 8708752 83 + 0.700 0.751 0.209
ENSG00000182621 E045 0.0000000       20 8715862 8716263 402 +      
ENSG00000182621 E046 6.1178566 0.004676258 0.125768250 0.32509386 20 8716264 8716348 85 + 0.715 0.956 0.940
ENSG00000182621 E047 6.6322193 0.004708095 0.050599566 0.18109500 20 8717671 8717848 178 + 0.728 1.016 1.109
ENSG00000182621 E048 4.7588484 0.006616675 0.216433092 0.44921069 20 8722354 8722421 68 + 0.630 0.846 0.884
ENSG00000182621 E049 6.0177236 0.005140239 0.600765405 0.77072955 20 8724656 8724752 97 + 0.740 0.847 0.423
ENSG00000182621 E050 5.4053867 0.011344726 0.093971585 0.27110664 20 8727309 8727393 85 + 0.753 0.479 -1.212
ENSG00000182621 E051 10.5491079 0.003208908 0.043893981 0.16483587 20 8729050 8729174 125 + 1.000 0.755 -0.940
ENSG00000182621 E052 0.0000000       20 8729175 8729899 725 +      
ENSG00000182621 E053 0.0000000       20 8732107 8732170 64 +      
ENSG00000182621 E054 13.2684205 0.004101665 0.069260109 0.22330625 20 8733238 8733392 155 + 1.081 0.887 -0.717
ENSG00000182621 E055 12.8276576 0.002788707 0.235295300 0.47123715 20 8737028 8737192 165 + 1.063 0.956 -0.392
ENSG00000182621 E056 8.7536291 0.022419145 0.299068369 0.53947875 20 8739261 8739360 100 + 0.925 0.802 -0.474
ENSG00000182621 E057 8.8433982 0.010038278 0.727031229 0.85244046 20 8740344 8740448 105 + 0.902 0.887 -0.059
ENSG00000182621 E058 10.3583461 0.003605463 0.779768614 0.88456908 20 8741464 8741573 110 + 0.958 0.957 -0.004
ENSG00000182621 E059 0.0000000       20 8750804 8750915 112 +      
ENSG00000182621 E060 0.2027342 0.038057620 0.103483881   20 8751122 8752348 1227 + 0.000 0.223 15.009
ENSG00000182621 E061 13.6237613 0.015650369 0.204685421 0.43552169 20 8757046 8757178 133 + 1.090 0.958 -0.487
ENSG00000182621 E062 8.3031020 0.025836134 0.905928215 0.95506716 20 8760407 8760460 54 + 0.867 0.923 0.212
ENSG00000182621 E063 6.1816125 0.007082415 0.439503135 0.65828902 20 8765139 8765168 30 + 0.787 0.701 -0.350
ENSG00000182621 E064 9.2638103 0.008331748 0.195527141 0.42400974 20 8765169 8765259 91 + 0.950 0.803 -0.561
ENSG00000182621 E065 8.7106434 0.005743411 0.179319299 0.40304597 20 8765260 8765358 99 + 0.919 0.756 -0.633
ENSG00000182621 E066 8.6262054 0.018378867 0.451222897 0.66651033 20 8774539 8774719 181 + 0.875 1.013 0.519
ENSG00000182621 E067 5.0661779 0.072350819 0.571210861 0.75118862 20 8788449 8788525 77 + 0.674 0.837 0.656
ENSG00000182621 E068 5.1894131 0.007590857 0.446673610 0.66319792 20 8788633 8788722 90 + 0.729 0.638 -0.381
ENSG00000182621 E069 4.7427282 0.030889746 0.589149465 0.76308219 20 8789518 8789545 28 + 0.690 0.635 -0.234
ENSG00000182621 E070 4.6847713 0.201893452 0.430845536 0.65177703 20 8789546 8789575 30 + 0.698 0.552 -0.638
ENSG00000182621 E071 4.1957226 0.066594466 0.274369067 0.51432426 20 8790175 8790195 21 + 0.664 0.475 -0.866
ENSG00000182621 E072 3.9684102 0.018994481 0.576372643 0.75469815 20 8790196 8790221 26 + 0.631 0.564 -0.295
ENSG00000182621 E073 5.4841659 0.006239897 0.194405577 0.42261855 20 8790222 8790261 40 + 0.753 0.566 -0.800
ENSG00000182621 E074 0.3336024 0.024441170 0.020171784   20 8792085 8792140 56 + 0.000 0.369 15.955
ENSG00000182621 E075 0.0000000       20 8792587 8792624 38 +      
ENSG00000182621 E076 0.5008152 0.052121648 0.657183667   20 8792625 8792790 166 + 0.166 0.000 -13.786
ENSG00000182621 E077 1.1010935 0.015378759 0.717997637   20 8802056 8802173 118 + 0.286 0.223 -0.473
ENSG00000182621 E078 0.0000000       20 8802174 8802493 320 +      
ENSG00000182621 E079 0.0000000       20 8880900 8880993 94 +      
ENSG00000182621 E080 3.2154123 0.021256039 0.058622494 0.19968777 20 8881622 8881627 6 + 0.597 0.223 -2.143
ENSG00000182621 E081 80.7178913 0.028122626 0.184894631 0.41035797 20 8881628 8884903 3276 + 1.775 1.935 0.539
ENSG00000182621 E082 0.1723744 0.117657602 0.107333431   20 8962196 8962307 112 + 0.000 0.223 14.817
ENSG00000182621 E083 0.0000000       20 8962308 8962336 29 +      
ENSG00000182621 E084 0.3040503 0.027442404 1.000000000   20 8962337 8962485 149 + 0.117 0.000 -13.292
ENSG00000182621 E085 0.7992560 0.243539045 0.931996282   20 8962486 8962892 407 + 0.209 0.224 0.124
ENSG00000182621 E086 0.0000000       20 8962893 8963010 118 +      
ENSG00000182621 E087 0.1614157 0.037917701 1.000000000   20 8965090 8965095 6 + 0.063 0.000 -12.405
ENSG00000182621 E088 0.2922838 0.025323853 0.311490165   20 8965096 8965151 56 + 0.063 0.222 2.107
ENSG00000182621 E089 0.4868358 0.175006502 0.595422243   20 8965152 8965435 284 + 0.119 0.221 1.076
ENSG00000182621 E090 1.3793980 0.013310759 0.364545202   20 8967220 8968360 1141 + 0.286 0.478 1.109