ENSG00000182612

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000571707 ENSG00000182612 HEK293_OSMI2_6hA HEK293_TMG_6hB TSPAN10 protein_coding retained_intron 3.81236 5.658755 1.77458 0.6210826 0.06095739 -1.667448 0.2074905 0.2345161 0.06636982 0.06426439 0.03407612 -1.6788551 0.05625833 0.04173333 0.03616667 -0.005566667 0.99754156 0.04959796 FALSE  
ENST00000571914 ENSG00000182612 HEK293_OSMI2_6hA HEK293_TMG_6hB TSPAN10 protein_coding processed_transcript 3.81236 5.658755 1.77458 0.6210826 0.06095739 -1.667448 0.2237778 0.2362326 0.21158437 0.06609355 0.03540953 -0.1521658 0.06916667 0.04483333 0.11896667 0.074133333 0.33110722 0.04959796    
ENST00000611590 ENSG00000182612 HEK293_OSMI2_6hA HEK293_TMG_6hB TSPAN10 protein_coding protein_coding 3.81236 5.658755 1.77458 0.6210826 0.06095739 -1.667448 3.1434657 4.7832943 1.41886868 0.54315210 0.01275431 -1.7461442 0.81383333 0.84590000 0.80153333 -0.044366667 0.77945066 0.04959796 FALSE  
ENST00000696048 ENSG00000182612 HEK293_OSMI2_6hA HEK293_TMG_6hB TSPAN10 protein_coding protein_coding 3.81236 5.658755 1.77458 0.6210826 0.06095739 -1.667448 0.1580029 0.3480168 0.00000000 0.11370873 0.00000000 -5.1619555 0.03597083 0.05860000 0.00000000 -0.058600000 0.04959796 0.04959796 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000182612 E001 0.0000000       17 81637171 81637171 1 +      
ENSG00000182612 E002 0.0000000       17 81637172 81637195 24 +      
ENSG00000182612 E003 0.3336024 0.027442404 1.000000000   17 81637196 81637201 6 + 0.000 0.119 8.719
ENSG00000182612 E004 34.8086546 0.001235122 0.024278324 0.10995887 17 81637202 81637406 205 + 1.564 1.419 -0.498
ENSG00000182612 E005 7.7295295 0.028079287 0.007159231 0.04537591 17 81637518 81639177 1660 + 1.110 0.738 -1.410
ENSG00000182612 E006 1.8930388 0.012224740 0.058884546 0.20023018 17 81642290 81642306 17 + 0.000 0.438 12.678
ENSG00000182612 E007 21.9819201 0.001896248 0.349501405 0.58679734 17 81642307 81642322 16 + 1.191 1.278 0.306
ENSG00000182612 E008 21.3963227 0.002297863 0.754173779 0.86923268 17 81642323 81642335 13 + 1.227 1.256 0.103
ENSG00000182612 E009 36.4611914 0.001031581 0.509787042 0.70782507 17 81642336 81642448 113 + 1.505 1.463 -0.145
ENSG00000182612 E010 85.9288640 0.001094094 0.841709833 0.92044322 17 81644992 81645629 638 + 1.830 1.840 0.032
ENSG00000182612 E011 2.5716502 0.010378188 0.946079687 0.97538317 17 81645630 81646581 952 + 0.474 0.462 -0.064
ENSG00000182612 E012 1.2802947 0.013057398 0.053417268   17 81647457 81647724 268 + 0.561 0.212 -2.066
ENSG00000182612 E013 0.3088520 0.025933025 0.295842568   17 81647725 81647900 176 + 0.220 0.063 -2.069
ENSG00000182612 E014 52.5713872 0.001291968 0.002705709 0.02160179 17 81647901 81648754 854 + 1.478 1.661 0.627