ENSG00000182504

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341893 ENSG00000182504 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP97 protein_coding protein_coding 4.895765 0.7637092 10.82849 0.105179 0.117151 3.808229 3.0895757 0.74455502 7.1751514 0.10069923 0.10854398 3.251321 0.6758750 0.97540000 0.66286667 -0.31253333 3.288026e-05 3.288026e-05 FALSE TRUE
ENST00000494050 ENSG00000182504 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP97 protein_coding protein_coding 4.895765 0.7637092 10.82849 0.105179 0.117151 3.808229 1.2555650 0.01326837 2.5793168 0.01326837 0.29058265 6.798057 0.1511042 0.01426667 0.23823333 0.22396667 2.809995e-03 3.288026e-05 FALSE TRUE
MSTRG.23373.3 ENSG00000182504 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP97 protein_coding   4.895765 0.7637092 10.82849 0.105179 0.117151 3.808229 0.2450066 0.00000000 0.2944667 0.00000000 0.06005744 4.928213 0.1301000 0.00000000 0.02716667 0.02716667 4.860113e-01 3.288026e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000182504 E001 1.196182 0.2248922890 7.764388e-01   3 101724593 101724613 21 + 0.236 0.001 -8.488
ENSG00000182504 E002 10.150244 0.0030274304 1.447089e-02 7.613513e-02 3 101724614 101724654 41 + 0.859 0.309 -2.588
ENSG00000182504 E003 10.292879 0.0029542317 1.327584e-02 7.155237e-02 3 101724655 101724657 3 + 0.865 0.309 -2.611
ENSG00000182504 E004 13.636571 0.0023511119 1.383057e-02 7.366084e-02 3 101724658 101724719 62 + 0.970 0.487 -2.009
ENSG00000182504 E005 28.352413 0.0023236534 1.199897e-01 3.158246e-01 3 101726594 101726736 143 + 1.248 1.055 -0.689
ENSG00000182504 E006 26.581133 0.0014344010 4.545233e-01 6.691444e-01 3 101727383 101727469 87 + 1.217 1.128 -0.316
ENSG00000182504 E007 30.807720 0.0029560855 5.754470e-01 7.539635e-01 3 101727470 101727541 72 + 1.280 1.218 -0.218
ENSG00000182504 E008 1.429534 0.0129977036 4.735338e-01 6.824653e-01 3 101728814 101728835 22 + 0.280 0.000 -11.037
ENSG00000182504 E009 34.727184 0.0050860557 1.939073e-01 4.220309e-01 3 101728836 101728937 102 + 1.336 1.190 -0.512
ENSG00000182504 E010 43.237199 0.0010911004 2.565368e-01 4.953141e-01 3 101731840 101731953 114 + 1.423 1.315 -0.375
ENSG00000182504 E011 51.084322 0.0021309704 2.221000e-01 4.559972e-01 3 101732488 101732610 123 + 1.487 1.376 -0.383
ENSG00000182504 E012 29.234290 0.0013481616 5.994121e-01 7.698308e-01 3 101732611 101732654 44 + 1.250 1.191 -0.210
ENSG00000182504 E013 50.331254 0.0035054476 8.528675e-02 2.551540e-01 3 101755430 101755594 165 + 1.483 1.316 -0.580
ENSG00000182504 E014 22.153347 0.0015091433 9.364018e-02 2.704971e-01 3 101757063 101757072 10 + 1.151 0.917 -0.860
ENSG00000182504 E015 50.424840 0.0058253166 2.690445e-01 5.088193e-01 3 101757073 101757196 124 + 1.483 1.376 -0.371
ENSG00000182504 E016 53.680054 0.0030267914 1.239851e-01 3.220435e-01 3 101757634 101757810 177 + 1.515 1.376 -0.480
ENSG00000182504 E017 123.538002 0.0005792773 7.162201e-02 2.280759e-01 3 101757811 101758423 613 + 1.864 1.763 -0.342
ENSG00000182504 E018 1.136443 0.0140050192 6.259260e-01   3 101758424 101759512 1089 + 0.205 0.309 0.782
ENSG00000182504 E019 28.290912 0.0016763351 7.439746e-01 8.629836e-01 3 101762485 101762560 76 + 1.235 1.270 0.122
ENSG00000182504 E020 0.975027 0.0156339368 5.221364e-01   3 101763109 101763186 78 + 0.177 0.309 1.045
ENSG00000182504 E021 203.205691 0.0029006234 9.882749e-01 9.959341e-01 3 101764847 101766445 1599 + 2.071 2.068 -0.010
ENSG00000182504 E022 376.310623 0.0002683141 2.055383e-12 2.002589e-10 3 101766446 101770562 4117 + 2.317 2.481 0.546