ENSG00000182473

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000332065 ENSG00000182473 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC7 protein_coding protein_coding 70.70827 103.903 40.77623 8.628965 1.795812 -1.349222 44.074553 69.491924 24.553979 7.4993079 1.2038269 -1.5005086244 0.61480833 0.6658667 0.6019000 -0.06396667 0.468217656 0.003273863 FALSE  
ENST00000589210 ENSG00000182473 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC7 protein_coding protein_coding 70.70827 103.903 40.77623 8.628965 1.795812 -1.349222 11.151413 17.421567 4.253623 3.6205333 0.5532851 -2.0315506262 0.14852083 0.1640000 0.1035667 -0.06043333 0.428607490 0.003273863 FALSE  
ENST00000634349 ENSG00000182473 HEK293_OSMI2_6hA HEK293_TMG_6hB EXOC7 protein_coding protein_coding 70.70827 103.903 40.77623 8.628965 1.795812 -1.349222 4.304985 3.529243 3.526957 0.3080865 0.3834165 -0.0009320837 0.07204167 0.0340000 0.0877000 0.05370000 0.003273863 0.003273863 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000182473 E001 13.4961959 0.0027665600 0.0148773283 0.077621817 17 76081016 76081016 1 - 0.782 1.168 1.440
ENSG00000182473 E002 13.6989301 0.0032189603 0.0132505898 0.071443468 17 76081017 76081017 1 - 0.782 1.173 1.460
ENSG00000182473 E003 501.1935457 1.2759255915 0.4471443008 0.663602641 17 76081018 76081246 229 - 2.435 2.684 0.829
ENSG00000182473 E004 2332.9042425 1.7609959910 0.4387744021 0.657810556 17 76081247 76082390 1144 - 3.041 3.361 1.063
ENSG00000182473 E005 247.6529602 0.9785974994 0.3667454724 0.601303103 17 76082391 76082391 1 - 2.101 2.383 0.945
ENSG00000182473 E006 1250.1692261 1.5791830723 0.4624389367 0.674819272 17 76082392 76082891 500 - 2.810 3.084 0.909
ENSG00000182473 E007 1289.3078791 1.6115333837 0.4968702946 0.698804993 17 76082892 76083518 627 - 2.851 3.092 0.801
ENSG00000182473 E008 319.3678878 1.1406400924 0.4733939973 0.682385401 17 76083519 76083575 57 - 2.279 2.481 0.672
ENSG00000182473 E009 173.6800709 0.9022824810 0.4436989130 0.661152960 17 76083576 76083576 1 - 2.019 2.217 0.663
ENSG00000182473 E010 384.5953364 1.1765045044 0.4303421841 0.651356901 17 76083577 76083647 71 - 2.319 2.569 0.834
ENSG00000182473 E011 493.6586352 0.0098105428 0.0796001695 0.244056073 17 76083648 76083750 103 - 2.498 2.664 0.553
ENSG00000182473 E012 609.8861781 0.0088444056 0.9972654101 1.000000000 17 76084006 76084139 134 - 2.639 2.743 0.345
ENSG00000182473 E013 382.0971096 0.0305816066 0.2889611008 0.529531796 17 76084248 76084289 42 - 2.507 2.520 0.045
ENSG00000182473 E014 7.8520743 0.0612038465 0.0948820206 0.272771353 17 76084290 76084516 227 - 1.023 0.832 -0.720
ENSG00000182473 E015 462.7196904 0.0315905084 0.3506116064 0.587783836 17 76084517 76084580 64 - 2.582 2.606 0.080
ENSG00000182473 E016 7.8360698 0.0735719637 0.0846186031 0.253988918 17 76084581 76084716 136 - 1.023 0.832 -0.723
ENSG00000182473 E017 5.0957357 0.1316087156 0.0481750484 0.175427379 17 76085110 76085313 204 - 0.949 0.633 -1.261
ENSG00000182473 E018 360.2437662 0.0178994627 0.2594145542 0.498371640 17 76085314 76085368 55 - 2.470 2.498 0.093
ENSG00000182473 E019 322.7526417 0.0183348327 0.2136427915 0.445928957 17 76085369 76085409 41 - 2.431 2.448 0.059
ENSG00000182473 E020 413.5217488 0.0110163903 0.1340447709 0.338164554 17 76085677 76085797 121 - 2.536 2.557 0.070
ENSG00000182473 E021 277.2315495 0.0004007773 0.0005107645 0.005775707 17 76086080 76086145 66 - 2.382 2.381 -0.003
ENSG00000182473 E022 1.9809385 0.3782015514 0.3439220255 0.581546421 17 76086854 76086892 39 - 0.513 0.400 -0.579
ENSG00000182473 E023 4.2900854 0.0067890357 0.0082859274 0.050640059 17 76087277 76087653 377 - 0.889 0.577 -1.279
ENSG00000182473 E024 311.1515511 0.0120433746 0.1340541498 0.338183191 17 76087654 76087720 67 - 2.416 2.433 0.057
ENSG00000182473 E025 29.8715840 0.1588205934 0.2480990426 0.485947504 17 76087721 76088059 339 - 1.483 1.408 -0.258
ENSG00000182473 E026 335.1433489 0.0141086020 0.0993948224 0.280698555 17 76088060 76088122 63 - 2.459 2.462 0.010
ENSG00000182473 E027 50.1376632 0.1326405489 0.0584973078 0.199399726 17 76088123 76088463 341 - 1.797 1.581 -0.735
ENSG00000182473 E028 441.0034912 0.0305691466 0.1126884656 0.303630465 17 76088464 76088562 99 - 2.603 2.571 -0.105
ENSG00000182473 E029 493.1014162 0.0388003168 0.1501435938 0.362581737 17 76088771 76088923 153 - 2.652 2.619 -0.110
ENSG00000182473 E030 486.6715783 0.0142945205 0.0928221318 0.268974990 17 76089175 76089320 146 - 2.620 2.623 0.012
ENSG00000182473 E031 63.7533556 0.1292343808 0.3240166517 0.563328454 17 76089321 76089808 488 - 1.757 1.743 -0.047
ENSG00000182473 E032 68.4103110 0.4057070642 0.4480375400 0.664244317 17 76090329 76090397 69 - 1.665 1.807 0.482
ENSG00000182473 E033 21.0433943 0.2509764495 0.9041189265 0.953965111 17 76090398 76090481 84 - 1.238 1.295 0.200
ENSG00000182473 E034 119.4364307 0.5590455594 0.4076648663 0.634243593 17 76091143 76091235 93 - 1.882 2.051 0.564
ENSG00000182473 E035 158.4458647 0.1139279069 0.0046155501 0.032556345 17 76092315 76094413 2099 - 2.365 2.028 -1.125
ENSG00000182473 E036 408.9374454 0.0099378745 0.0598593364 0.202457198 17 76094414 76094510 97 - 2.543 2.548 0.015
ENSG00000182473 E037 364.3011588 0.0264215848 0.0936511941 0.270519752 17 76094511 76094581 71 - 2.520 2.489 -0.105
ENSG00000182473 E038 430.3300666 0.0224762944 0.0283482631 0.122336529 17 76097796 76097913 118 - 2.612 2.553 -0.197
ENSG00000182473 E039 362.2754835 0.0176099359 0.0182292649 0.089783903 17 76097914 76097988 75 - 2.534 2.480 -0.181
ENSG00000182473 E040 270.6994335 0.0135796366 0.0047896403 0.033474262 17 76097989 76098018 30 - 2.420 2.350 -0.233
ENSG00000182473 E041 5.8835952 0.0053220366 0.0007175680 0.007591549 17 76101012 76101270 259 - 1.023 0.655 -1.439
ENSG00000182473 E042 424.4953296 0.0186380215 0.0026878942 0.021497964 17 76101271 76101376 106 - 2.636 2.536 -0.334
ENSG00000182473 E043 504.0329647 0.0182326594 0.0223740961 0.103815194 17 76101679 76101863 185 - 2.672 2.625 -0.157
ENSG00000182473 E044 2.1070776 0.0103697183 0.0113301137 0.063722931 17 76103084 76103360 277 - 0.693 0.325 -1.823
ENSG00000182473 E045 308.3240912 0.0060377556 0.0020239729 0.017217549 17 76103361 76103426 66 - 2.452 2.417 -0.119
ENSG00000182473 E046 1.5905021 0.0121989077 0.0092775753 0.055006039 17 76103427 76103523 97 - 0.640 0.241 -2.183
ENSG00000182473 E047 260.9896491 0.0035873768 0.0116586414 0.065068537 17 76103633 76103677 45 - 2.354 2.354 0.000
ENSG00000182473 E048 203.9184118 0.0026574085 0.0033204732 0.025323007 17 76103678 76103787 110 - 2.261 2.245 -0.055
ENSG00000182473 E049 0.9419927 0.2592075597 1.0000000000   17 76120331 76120454 124 - 0.194 0.250 0.470
ENSG00000182473 E050 1.0728609 0.0403860404 0.7991987011   17 76120864 76120978 115 - 0.194 0.286 0.731
ENSG00000182473 E051 0.2735028 0.0257860379 0.3341910639   17 76121428 76121576 149 - 0.193 0.074 -1.602