ENSG00000182400

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330149 ENSG00000182400 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC6B protein_coding protein_coding 9.56907 2.653019 15.81075 0.4739705 0.5641197 2.570683 6.0134164 1.46832992 10.1863853 0.30099500 0.5240149 2.786018 0.65939583 0.55226667 0.64353333 0.09126667 0.59798973 0.02470986 FALSE  
ENST00000347691 ENSG00000182400 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC6B protein_coding protein_coding 9.56907 2.653019 15.81075 0.4739705 0.5641197 2.570683 1.7135982 1.01935113 3.2771681 0.31721737 0.3434880 1.675110 0.18187500 0.37480000 0.20846667 -0.16633333 0.36175493 0.02470986 FALSE  
ENST00000555269 ENSG00000182400 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC6B protein_coding nonsense_mediated_decay 9.56907 2.653019 15.81075 0.4739705 0.5641197 2.570683 0.6384549 0.06143641 0.9424125 0.06143641 0.3255842 3.736855 0.05289167 0.01966667 0.05833333 0.03866667 0.62780228 0.02470986    
MSTRG.9437.6 ENSG00000182400 HEK293_OSMI2_6hA HEK293_TMG_6hB TRAPPC6B protein_coding   9.56907 2.653019 15.81075 0.4739705 0.5641197 2.570683 0.3979265 0.00000000 0.7936716 0.00000000 0.2411145 6.328534 0.02946250 0.00000000 0.05136667 0.05136667 0.02470986 0.02470986    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000182400 E001 1.4757248 0.015692051 0.968051865 0.98589569 14 39143212 39143279 68 - 0.318 0.405 0.515
ENSG00000182400 E002 0.4458772 0.021768165 0.077550402   14 39147811 39147811 1 - 0.055 0.405 3.515
ENSG00000182400 E003 0.4458772 0.021768165 0.077550402   14 39147812 39147813 2 - 0.055 0.405 3.515
ENSG00000182400 E004 112.5455859 1.157560072 0.346179485 0.58372150 14 39147814 39148381 568 - 1.838 2.188 1.173
ENSG00000182400 E005 163.8402970 1.325898461 0.384578276 0.61614593 14 39148382 39149324 943 - 2.005 2.334 1.098
ENSG00000182400 E006 51.7683269 0.665706051 0.345694207 0.58329436 14 39149325 39149500 176 - 1.525 1.808 0.961
ENSG00000182400 E007 58.1337196 0.694682944 0.362014833 0.59735120 14 39149501 39149987 487 - 1.582 1.834 0.856
ENSG00000182400 E008 9.9716316 0.284827643 0.570363517 0.75049177 14 39149988 39149989 2 - 0.875 1.068 0.719
ENSG00000182400 E009 40.8134257 0.574227299 0.374451167 0.60770099 14 39149990 39150117 128 - 1.441 1.659 0.747
ENSG00000182400 E010 70.7047099 0.786521223 0.525418171 0.71876986 14 39150118 39150381 264 - 1.692 1.821 0.436
ENSG00000182400 E011 50.0699270 0.021297186 0.088589799 0.26116805 14 39151746 39151796 51 - 1.568 1.567 -0.006
ENSG00000182400 E012 46.8610274 0.052505309 0.063467915 0.21051801 14 39151797 39151810 14 - 1.547 1.489 -0.201
ENSG00000182400 E013 51.0324862 0.036749770 0.028573793 0.12306587 14 39151811 39151839 29 - 1.586 1.517 -0.236
ENSG00000182400 E014 52.5512468 0.043488016 0.004522354 0.03206144 14 39154211 39154294 84 - 1.610 1.446 -0.561
ENSG00000182400 E015 71.5299925 0.082757108 0.094371548 0.27186069 14 39158285 39158402 118 - 1.725 1.679 -0.155
ENSG00000182400 E016 8.0651944 0.364376302 0.748227430 0.86564451 14 39158403 39159449 1047 - 0.799 0.981 0.698
ENSG00000182400 E017 4.6954747 0.006470334 0.179458898 0.40327855 14 39159450 39159482 33 - 0.583 0.900 1.294
ENSG00000182400 E018 57.2285982 0.106945557 0.137250012 0.34332315 14 39159483 39159550 68 - 1.630 1.583 -0.162
ENSG00000182400 E019 34.1935170 0.076865173 0.034084567 0.13909272 14 39170015 39170017 3 - 1.425 1.282 -0.498
ENSG00000182400 E020 95.3002423 0.100320774 0.341300442 0.57925909 14 39170018 39170532 515 - 1.832 1.890 0.196