ENSG00000182240

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328735 ENSG00000182240 HEK293_OSMI2_6hA HEK293_TMG_6hB BACE2 protein_coding protein_coding 23.84152 30.63765 13.21474 3.47822 0.5309912 -1.212538 3.0745254 4.0413854 1.0306182 0.4865813 0.11976401 -1.9609746 0.12406667 0.13213333 0.07893333 -0.05320000 2.266868e-01 3.469001e-05 FALSE  
ENST00000330333 ENSG00000182240 HEK293_OSMI2_6hA HEK293_TMG_6hB BACE2 protein_coding protein_coding 23.84152 30.63765 13.21474 3.47822 0.5309912 -1.212538 0.8410592 0.5315904 0.9537911 0.1036672 0.08885862 0.8315183 0.04569583 0.01710000 0.07256667 0.05546667 3.469001e-05 3.469001e-05 FALSE  
ENST00000465326 ENSG00000182240 HEK293_OSMI2_6hA HEK293_TMG_6hB BACE2 protein_coding processed_transcript 23.84152 30.63765 13.21474 3.47822 0.5309912 -1.212538 9.5978053 12.8543202 6.4419729 1.1015595 0.77991710 -0.9955629 0.42217917 0.42230000 0.48493333 0.06263333 7.518095e-01 3.469001e-05 FALSE  
ENST00000466122 ENSG00000182240 HEK293_OSMI2_6hA HEK293_TMG_6hB BACE2 protein_coding processed_transcript 23.84152 30.63765 13.21474 3.47822 0.5309912 -1.212538 2.1855748 2.1876883 0.0000000 1.1565378 0.00000000 -7.7798430 0.07284167 0.07826667 0.00000000 -0.07826667 3.913678e-01 3.469001e-05 FALSE  
ENST00000487994 ENSG00000182240 HEK293_OSMI2_6hA HEK293_TMG_6hB BACE2 protein_coding processed_transcript 23.84152 30.63765 13.21474 3.47822 0.5309912 -1.212538 6.7148706 8.1552799 4.5097830 0.7307152 0.30035349 -0.8532488 0.28402083 0.26770000 0.34253333 0.07483333 4.635187e-01 3.469001e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000182240 E001 3.0923464 0.1263873183 3.288428e-01 5.678035e-01 21 41167801 41168159 359 + 0.408 0.624 1.040
ENSG00000182240 E002 3.3650413 0.0220562356 4.958353e-02 1.786145e-01 21 41168160 41168200 41 + 0.309 0.682 1.875
ENSG00000182240 E003 3.1621195 0.0691426050 2.203824e-02 1.027087e-01 21 41168201 41168213 13 + 0.181 0.679 2.862
ENSG00000182240 E004 81.3879175 0.0004607776 1.274169e-01 3.277614e-01 21 41168214 41168575 362 + 1.811 1.880 0.230
ENSG00000182240 E005 3.0552617 0.0082287301 1.620382e-02 8.253696e-02 21 41225476 41225695 220 + 0.181 0.645 2.722
ENSG00000182240 E006 70.1080182 0.0015111856 1.971571e-01 4.260405e-01 21 41226266 41226302 37 + 1.838 1.777 -0.205
ENSG00000182240 E007 89.9413988 0.0056853001 3.382864e-01 5.764996e-01 21 41226303 41226354 52 + 1.937 1.890 -0.159
ENSG00000182240 E008 0.0000000       21 41230118 41230223 106 +      
ENSG00000182240 E009 0.3150090 0.0277603343 4.900978e-01   21 41236628 41236664 37 + 0.181 0.080 -1.365
ENSG00000182240 E010 217.0870868 0.0020661290 5.922990e-01 7.651446e-01 21 41237513 41237729 217 + 2.297 2.282 -0.050
ENSG00000182240 E011 0.4756169 0.0344276838 3.593819e-01   21 41241745 41241818 74 + 0.001 0.205 8.571
ENSG00000182240 E012 179.5864019 0.0003378474 5.718579e-01 7.515971e-01 21 41241819 41241939 121 + 2.190 2.208 0.058
ENSG00000182240 E013 80.6489846 0.0004878098 3.121303e-01 5.524679e-01 21 41241940 41241947 8 + 1.825 1.870 0.153
ENSG00000182240 E014 147.3713896 0.0002908470 1.435258e-01 3.526777e-01 21 41243376 41243510 135 + 2.084 2.132 0.161
ENSG00000182240 E015 124.6191648 0.0005318028 1.707174e-02 8.572525e-02 21 41245962 41246063 102 + 1.984 2.072 0.294
ENSG00000182240 E016 0.4231520 0.1409115120 8.098482e-01   21 41246064 41246271 208 + 0.181 0.144 -0.395
ENSG00000182240 E017 166.0794193 0.0006585604 1.198291e-01 3.155731e-01 21 41250752 41250901 150 + 2.136 2.186 0.169
ENSG00000182240 E018 0.0000000       21 41252465 41252524 60 +      
ENSG00000182240 E019 175.4444178 0.0028849960 1.013784e-01 2.843192e-01 21 41257158 41257326 169 + 2.150 2.214 0.216
ENSG00000182240 E020 440.8364870 0.0022024573 6.833855e-03 4.386204e-02 21 41275371 41276744 1374 + 2.541 2.612 0.240
ENSG00000182240 E021 54.1655935 0.0058317047 6.730908e-23 2.741158e-20 21 41276745 41279693 2949 + 2.020 1.442 -1.959
ENSG00000182240 E022 64.3607677 0.0007294559 6.481230e-20 1.900971e-17 21 41279694 41282530 2837 + 2.013 1.604 -1.381