ENSG00000182197

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000684189 ENSG00000182197 HEK293_OSMI2_6hA HEK293_TMG_6hB EXT1 protein_coding processed_transcript 19.87755 21.37138 20.65068 1.309272 1.246185 -0.04946729 2.487056 3.580184 0.000000 0.5248474 0.0000000 -8.48791401 0.1204083 0.1657667 0.0000000 -0.16576667 1.877877e-23 1.877877e-23 FALSE TRUE
MSTRG.32017.3 ENSG00000182197 HEK293_OSMI2_6hA HEK293_TMG_6hB EXT1 protein_coding   19.87755 21.37138 20.65068 1.309272 1.246185 -0.04946729 3.483363 3.659343 4.137149 0.3028358 0.2179342 0.17659817 0.1760167 0.1714000 0.2027000 0.03130000 7.984394e-01 1.877877e-23 TRUE TRUE
MSTRG.32017.6 ENSG00000182197 HEK293_OSMI2_6hA HEK293_TMG_6hB EXT1 protein_coding   19.87755 21.37138 20.65068 1.309272 1.246185 -0.04946729 5.139545 5.059945 7.085268 0.2428546 0.9154895 0.48488717 0.2580125 0.2378333 0.3403000 0.10246667 2.155338e-01 1.877877e-23 FALSE TRUE
MSTRG.32017.7 ENSG00000182197 HEK293_OSMI2_6hA HEK293_TMG_6hB EXT1 protein_coding   19.87755 21.37138 20.65068 1.309272 1.246185 -0.04946729 7.293952 8.249508 8.184177 0.4083182 0.1156221 -0.01145671 0.3684792 0.3868667 0.3989333 0.01206667 9.690915e-01 1.877877e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000182197 E001 0.1779838 0.0327792461 0.3841512963   8 117764854 117764900 47 - 0.136 0.000 -9.554
ENSG00000182197 E002 31.9455116 0.0412987801 0.1595255216 0.376056394 8 117794490 117797934 3445 - 1.592 1.437 -0.532
ENSG00000182197 E003 2.2918387 0.0092838593 0.1301634324 0.332087246 8 117797935 117798060 126 - 0.634 0.383 -1.221
ENSG00000182197 E004 1.7025190 0.0117157448 0.6945857379 0.832045778 8 117798061 117798091 31 - 0.453 0.384 -0.374
ENSG00000182197 E005 0.9408952 0.0153943821 0.6103857100   8 117798092 117798149 58 - 0.239 0.329 0.625
ENSG00000182197 E006 1.5953037 0.0111773497 0.6933480902 0.831256381 8 117798150 117798206 57 - 0.453 0.383 -0.375
ENSG00000182197 E007 7.6156008 0.0118549019 0.0334738963 0.137406335 8 117798207 117799088 882 - 1.066 0.805 -0.983
ENSG00000182197 E008 15.4340077 0.0021607468 0.5329125107 0.724122270 8 117799089 117799413 325 - 1.175 1.227 0.186
ENSG00000182197 E009 14.8055824 0.0022709946 0.3705744797 0.604390653 8 117799414 117799420 7 - 1.142 1.220 0.278
ENSG00000182197 E010 102.3057565 0.0011310236 0.2392719786 0.475728630 8 117799421 117799572 152 - 1.980 2.023 0.144
ENSG00000182197 E011 76.0670915 0.0053259435 0.5767390072 0.754945030 8 117799573 117799586 14 - 1.860 1.889 0.097
ENSG00000182197 E012 98.8310068 0.0040520758 0.2573797594 0.496123800 8 117799587 117799645 59 - 1.961 2.012 0.174
ENSG00000182197 E013 151.2302979 0.0018341714 0.0037478412 0.027732882 8 117799646 117799756 111 - 2.114 2.214 0.334
ENSG00000182197 E014 142.1238224 0.0004138848 0.0053728662 0.036558869 8 117799757 117799819 63 - 2.101 2.184 0.278
ENSG00000182197 E015 148.5825140 0.0003849879 0.0084947831 0.051580719 8 117799820 117799897 78 - 2.122 2.199 0.256
ENSG00000182197 E016 205.4769454 0.0002685730 0.0070760200 0.044970215 8 117804722 117804893 172 - 2.271 2.336 0.219
ENSG00000182197 E017 9.7500802 0.0158096981 0.1192189124 0.314575185 8 117804894 117806902 2009 - 1.129 0.949 -0.660
ENSG00000182197 E018 184.6674217 0.0004568234 0.9039271820 0.953858217 8 117807217 117807377 161 - 2.264 2.266 0.004
ENSG00000182197 E019 146.7925062 0.0004084754 0.3853031695 0.616719669 8 117812872 117812961 90 - 2.152 2.176 0.079
ENSG00000182197 E020 137.2035364 0.0003908370 0.0465525895 0.171434466 8 117818435 117818530 96 - 2.103 2.162 0.199
ENSG00000182197 E021 127.8318644 0.0025505485 0.0179991984 0.089027724 8 117819676 117819794 119 - 2.050 2.142 0.307
ENSG00000182197 E022 136.8435872 0.0004633005 0.8744358636 0.938431780 8 117822465 117822597 133 - 2.137 2.130 -0.023
ENSG00000182197 E023 135.8065154 0.0071568293 0.1621515322 0.379978745 8 117830230 117830349 120 - 2.170 2.097 -0.244
ENSG00000182197 E024 0.2027342 0.0342431638 0.6087165883   8 117831599 117831653 55 - 0.000 0.109 8.774
ENSG00000182197 E025 122.6064633 0.0039378805 0.2407631533 0.477441334 8 117835444 117835551 108 - 2.116 2.063 -0.178
ENSG00000182197 E026 130.7078447 0.0025688189 0.1114190466 0.301359657 8 117837108 117837201 94 - 2.150 2.087 -0.212
ENSG00000182197 E027 0.0000000       8 118016807 118017235 429 -      
ENSG00000182197 E028 220.9698293 0.0005338189 0.0013062589 0.012210756 8 118110085 118110329 245 - 2.387 2.305 -0.275
ENSG00000182197 E029 134.2167335 0.0004089142 0.0205952958 0.098011907 8 118110330 118110487 158 - 2.165 2.091 -0.248
ENSG00000182197 E030 238.0971512 0.0002358427 0.0007617344 0.007959637 8 118110488 118110965 478 - 2.416 2.336 -0.264
ENSG00000182197 E031 57.0419212 0.0014985939 0.6548535905 0.806652895 8 118110966 118110973 8 - 1.769 1.744 -0.082
ENSG00000182197 E032 67.8073716 0.0007156599 0.5510431054 0.737069306 8 118110974 118111009 36 - 1.846 1.817 -0.095
ENSG00000182197 E033 180.3404940 0.0002885197 0.4214155320 0.644669494 8 118111010 118111397 388 - 2.266 2.243 -0.078
ENSG00000182197 E034 85.8469291 0.0006326590 0.6685178680 0.815235602 8 118111398 118111826 429 - 1.945 1.926 -0.063
ENSG00000182197 E035 0.7389688 0.0182217683 0.1013176929   8 118111852 118111907 56 - 0.392 0.108 -2.375