ENSG00000182179

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333486 ENSG00000182179 HEK293_OSMI2_6hA HEK293_TMG_6hB UBA7 protein_coding protein_coding 1.631185 1.478525 1.988354 0.6305487 0.60216 0.4249287 0.36090447 0.52920327 0.19722202 0.12355837 0.00778480 -1.3796519 0.26377500 0.43766667 0.11430000 -0.32336667 0.04854327 0.04854327 FALSE TRUE
ENST00000460516 ENSG00000182179 HEK293_OSMI2_6hA HEK293_TMG_6hB UBA7 protein_coding retained_intron 1.631185 1.478525 1.988354 0.6305487 0.60216 0.4249287 0.10586939 0.03092805 0.17909050 0.03092805 0.13415743 2.2079151 0.06354583 0.01150000 0.07000000 0.05850000 0.71212738 0.04854327 FALSE FALSE
ENST00000460703 ENSG00000182179 HEK293_OSMI2_6hA HEK293_TMG_6hB UBA7 protein_coding retained_intron 1.631185 1.478525 1.988354 0.6305487 0.60216 0.4249287 0.29609105 0.31511736 0.35744406 0.20272748 0.05116225 0.1765640 0.18606667 0.17123333 0.19556667 0.02433333 1.00000000 0.04854327 FALSE FALSE
ENST00000473992 ENSG00000182179 HEK293_OSMI2_6hA HEK293_TMG_6hB UBA7 protein_coding retained_intron 1.631185 1.478525 1.988354 0.6305487 0.60216 0.4249287 0.13546857 0.23391978 0.10958857 0.14014314 0.10958857 -1.0283273 0.06998750 0.12120000 0.03433333 -0.08686667 0.62159800 0.04854327 TRUE FALSE
ENST00000478688 ENSG00000182179 HEK293_OSMI2_6hA HEK293_TMG_6hB UBA7 protein_coding retained_intron 1.631185 1.478525 1.988354 0.6305487 0.60216 0.4249287 0.10035939 0.02157807 0.17705541 0.02157807 0.05921746 2.5664708 0.06114583 0.03830000 0.11773333 0.07943333 0.53457488 0.04854327 FALSE TRUE
ENST00000478875 ENSG00000182179 HEK293_OSMI2_6hA HEK293_TMG_6hB UBA7 protein_coding retained_intron 1.631185 1.478525 1.988354 0.6305487 0.60216 0.4249287 0.08273449 0.07747888 0.29251738 0.07747888 0.19208276 1.7900114 0.03423750 0.02883333 0.12410000 0.09526667 0.76116541 0.04854327   FALSE
ENST00000483751 ENSG00000182179 HEK293_OSMI2_6hA HEK293_TMG_6hB UBA7 protein_coding retained_intron 1.631185 1.478525 1.988354 0.6305487 0.60216 0.4249287 0.14115567 0.10049600 0.08880437 0.01519460 0.08880437 -0.1613475 0.09857917 0.08920000 0.06170000 -0.02750000 0.71350806 0.04854327 FALSE TRUE
ENST00000489826 ENSG00000182179 HEK293_OSMI2_6hA HEK293_TMG_6hB UBA7 protein_coding retained_intron 1.631185 1.478525 1.988354 0.6305487 0.60216 0.4249287 0.10437273 0.00000000 0.16788368 0.00000000 0.16788368 4.1528622 0.06039167 0.00000000 0.11666667 0.11666667 0.93069845 0.04854327 FALSE TRUE
ENST00000494212 ENSG00000182179 HEK293_OSMI2_6hA HEK293_TMG_6hB UBA7 protein_coding processed_transcript 1.631185 1.478525 1.988354 0.6305487 0.60216 0.4249287 0.13343936 0.05696280 0.14841415 0.05696280 0.09552498 1.2422694 0.06462500 0.04806667 0.06370000 0.01563333 0.87901189 0.04854327 FALSE TRUE
ENST00000497908 ENSG00000182179 HEK293_OSMI2_6hA HEK293_TMG_6hB UBA7 protein_coding retained_intron 1.631185 1.478525 1.988354 0.6305487 0.60216 0.4249287 0.11993037 0.11284091 0.17075737 0.07789519 0.11675756 0.5572634 0.06604167 0.05396667 0.07070000 0.01673333 1.00000000 0.04854327   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000182179 E001 0.0000000       3 49805209 49805223 15 -      
ENSG00000182179 E002 2.8047733 0.012897251 0.5917498548 0.764936255 3 49805224 49805437 214 - 0.612 0.526 -0.389
ENSG00000182179 E003 3.6805567 0.008055894 0.1837232060 0.408741376 3 49805897 49805997 101 - 0.506 0.720 0.943
ENSG00000182179 E004 0.6951069 0.067711134 0.7275300292   3 49805998 49806072 75 - 0.159 0.233 0.687
ENSG00000182179 E005 4.3775689 0.006862077 0.4059536972 0.633014442 3 49806073 49806136 64 - 0.612 0.740 0.540
ENSG00000182179 E006 3.1232126 0.008667792 0.4340560394 0.654279850 3 49806137 49806165 29 - 0.506 0.634 0.582
ENSG00000182179 E007 0.6592102 0.023141305 0.5404815964   3 49806166 49806290 125 - 0.275 0.168 -0.906
ENSG00000182179 E008 8.3443090 0.023671510 0.2941359816 0.534710543 3 49807736 49807927 192 - 0.857 0.988 0.494
ENSG00000182179 E009 5.2074924 0.007973910 0.6985369495 0.834654627 3 49808020 49808041 22 - 0.734 0.792 0.234
ENSG00000182179 E010 7.4025563 0.004430625 0.4114862819 0.637198714 3 49808042 49808112 71 - 0.828 0.932 0.398
ENSG00000182179 E011 6.8981096 0.009676886 0.4459836238 0.662707213 3 49808386 49808468 83 - 0.799 0.896 0.376
ENSG00000182179 E012 3.6946611 0.028778686 0.7211045414 0.848855485 3 49808976 49809007 32 - 0.612 0.659 0.207
ENSG00000182179 E013 6.8094877 0.021275675 0.2754987883 0.515578087 3 49809008 49809159 152 - 0.768 0.910 0.553
ENSG00000182179 E014 1.1632183 0.438669246 0.5412019090   3 49809160 49809183 24 - 0.440 0.237 -1.272
ENSG00000182179 E015 2.7994081 0.030655905 0.3303824949 0.569335768 3 49809184 49809389 206 - 0.656 0.496 -0.726
ENSG00000182179 E016 4.3927887 0.008540187 0.7097554983 0.841656253 3 49809390 49809464 75 - 0.733 0.680 -0.220
ENSG00000182179 E017 1.3607344 0.016001490 0.0221315218   3 49809465 49809541 77 - 0.562 0.168 -2.489
ENSG00000182179 E018 3.9543020 0.164598787 0.5038875370 0.703496204 3 49809542 49809574 33 - 0.619 0.688 0.293
ENSG00000182179 E019 6.2958923 0.043135084 0.6269031118 0.788453918 3 49809575 49809725 151 - 0.801 0.855 0.213
ENSG00000182179 E020 4.2626040 0.007898136 0.6646221752 0.812772789 3 49809815 49809879 65 - 0.656 0.720 0.267
ENSG00000182179 E021 0.1308682 0.042025557 0.7949781015   3 49809880 49809887 8 - 0.000 0.092 8.513
ENSG00000182179 E022 1.9458342 0.248393639 0.4460722684 0.662787793 3 49809978 49809978 1 - 0.361 0.499 0.734
ENSG00000182179 E023 5.5557422 0.019640214 0.0095180750 0.056046742 3 49809979 49810183 205 - 0.506 0.906 1.677
ENSG00000182179 E024 2.4590285 0.187834417 0.4563769080 0.670554251 3 49810184 49810262 79 - 0.616 0.461 -0.727
ENSG00000182179 E025 4.9558775 0.014855174 0.4053790138 0.632611491 3 49810263 49810428 166 - 0.829 0.719 -0.440
ENSG00000182179 E026 2.8297114 0.009296953 0.5779562305 0.755792683 3 49810460 49810516 57 - 0.612 0.527 -0.387
ENSG00000182179 E027 1.9026079 0.013924564 0.4624892185 0.674831543 3 49810517 49810525 9 - 0.506 0.384 -0.637
ENSG00000182179 E028 4.8596031 0.006115226 0.9867372198 0.995224783 3 49810526 49810672 147 - 0.734 0.740 0.025
ENSG00000182179 E029 4.3721471 0.017059277 0.4589253049 0.672455908 3 49810752 49810832 81 - 0.612 0.741 0.543
ENSG00000182179 E030 5.1846634 0.031264573 0.4805901384 0.687491172 3 49810984 49811091 108 - 0.832 0.721 -0.442
ENSG00000182179 E031 6.0402558 0.121040301 0.4222850483 0.645365479 3 49811092 49811272 181 - 0.860 0.801 -0.229
ENSG00000182179 E032 4.1032991 0.007471150 0.4188294341 0.642733985 3 49811273 49811369 97 - 0.767 0.657 -0.457
ENSG00000182179 E033 4.5811518 0.007366160 0.0266066846 0.117088028 3 49811370 49811455 86 - 0.906 0.609 -1.202
ENSG00000182179 E034 4.4573211 0.022300126 0.0002951072 0.003679859 3 49811456 49811869 414 - 0.991 0.461 -2.221
ENSG00000182179 E035 3.5635032 0.009571499 0.3188001526 0.558566400 3 49811870 49812016 147 - 0.733 0.584 -0.637
ENSG00000182179 E036 2.4846297 0.527821884 0.5420347159 0.730525782 3 49812109 49812206 98 - 0.269 0.619 1.883
ENSG00000182179 E037 2.1101413 0.565909900 0.7899028871 0.890504862 3 49812408 49812447 40 - 0.357 0.534 0.928
ENSG00000182179 E038 2.4914796 0.176685468 0.9396263033 0.972034513 3 49812448 49812543 96 - 0.502 0.535 0.161
ENSG00000182179 E039 1.2972228 0.076465952 0.5428894844   3 49812648 49812738 91 - 0.274 0.384 0.697
ENSG00000182179 E040 2.8843915 0.216123118 0.4552796733 0.669729828 3 49813062 49813168 107 - 0.437 0.647 0.986
ENSG00000182179 E041 3.8969806 0.017818016 0.8657997115 0.933641754 3 49813249 49813383 135 - 0.696 0.678 -0.078
ENSG00000182179 E042 4.4016698 0.006437082 0.5121188877 0.709546610 3 49813479 49813647 169 - 0.768 0.679 -0.363
ENSG00000182179 E043 3.5145996 0.007950729 0.8748091920 0.938648547 3 49813732 49813953 222 - 0.656 0.633 -0.098