ENSG00000182095

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000328270 ENSG00000182095 HEK293_OSMI2_6hA HEK293_TMG_6hB TNRC18 protein_coding protein_coding 18.30287 25.31293 14.7979 2.109567 0.4339575 -0.7740774 3.019539 5.398437 2.275969 0.3037625 0.2911879 -1.2424061 0.1567875 0.2156 0.1533667 -0.06223333 0.467597368 0.009974048 FALSE FALSE
ENST00000430969 ENSG00000182095 HEK293_OSMI2_6hA HEK293_TMG_6hB TNRC18 protein_coding protein_coding 18.30287 25.31293 14.7979 2.109567 0.4339575 -0.7740774 5.374006 7.555910 3.534986 1.1392892 0.4558725 -1.0937335 0.2913792 0.2965 0.2395333 -0.05696667 0.744847850 0.009974048 FALSE TRUE
ENST00000440081 ENSG00000182095 HEK293_OSMI2_6hA HEK293_TMG_6hB TNRC18 protein_coding protein_coding 18.30287 25.31293 14.7979 2.109567 0.4339575 -0.7740774 5.619547 6.095633 5.351873 0.3663789 0.2064458 -0.1874038 0.3155083 0.2421 0.3615333 0.11943333 0.009974048 0.009974048 FALSE FALSE
MSTRG.29435.1 ENSG00000182095 HEK293_OSMI2_6hA HEK293_TMG_6hB TNRC18 protein_coding   18.30287 25.31293 14.7979 2.109567 0.4339575 -0.7740774 1.548461 2.228732 1.658269 0.7684968 0.3607776 -0.4243299 0.0759625 0.0860 0.1114667 0.02546667 0.842756547 0.009974048 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000182095 E001 0.0000000       7 5306294 5306638 345 -      
ENSG00000182095 E002 0.0000000       7 5306639 5306789 151 -      
ENSG00000182095 E003 3.0975757 0.0529863220 2.311321e-01 0.4664640291 7 5306790 5306810 21 - 0.395 0.623 1.109
ENSG00000182095 E004 84.7838266 0.0163387508 2.493983e-02 0.1120354045 7 5306811 5307299 489 - 1.770 1.937 0.563
ENSG00000182095 E005 268.2739810 0.0009732145 3.362364e-01 0.5746788006 7 5307300 5307944 645 - 2.376 2.402 0.087
ENSG00000182095 E006 55.0198256 0.0009643872 9.928813e-01 0.9980713969 7 5307945 5307956 12 - 1.716 1.717 0.004
ENSG00000182095 E007 71.7358530 0.0005245282 1.006311e-01 0.2829242397 7 5307957 5308007 51 - 1.770 1.848 0.262
ENSG00000182095 E008 52.4633636 0.0007268151 1.170372e-02 0.0652514888 7 5308008 5308024 17 - 1.587 1.728 0.479
ENSG00000182095 E009 206.3393539 0.0003282883 4.621698e-06 0.0001075460 7 5308025 5308312 288 - 2.186 2.318 0.439
ENSG00000182095 E010 110.8423866 0.0004436880 1.746786e-04 0.0023885862 7 5308875 5308949 75 - 1.904 2.050 0.490
ENSG00000182095 E011 189.5935575 0.0002761771 2.697441e-02 0.1182374772 7 5309132 5309368 237 - 2.196 2.260 0.215
ENSG00000182095 E012 207.9864563 0.0030596623 1.116698e-02 0.0630706848 7 5312503 5313110 608 - 2.210 2.308 0.327
ENSG00000182095 E013 278.9628132 0.0004499412 1.135883e-03 0.0109359446 7 5313111 5313859 749 - 2.352 2.433 0.271
ENSG00000182095 E014 53.2133306 0.0007939294 8.716211e-01 0.9368377948 7 5313860 5313863 4 - 1.703 1.696 -0.024
ENSG00000182095 E015 1.3269625 0.0135550482 2.514052e-01   7 5314980 5314983 4 - 0.175 0.393 1.573
ENSG00000182095 E016 138.7478649 0.0003709256 8.087978e-01 0.9014817296 7 5314984 5315148 165 - 2.103 2.112 0.029
ENSG00000182095 E017 127.8699140 0.0016029192 2.694475e-01 0.5092696874 7 5315956 5316072 117 - 2.101 2.057 -0.148
ENSG00000182095 E018 0.2852693 0.2900531534 9.449876e-02   7 5320140 5320317 178 - 0.295 0.000 -11.574
ENSG00000182095 E019 120.6913522 0.0007415819 8.639962e-02 0.2572207451 7 5320318 5320426 109 - 2.088 2.025 -0.208
ENSG00000182095 E020 100.7293081 0.0084287719 8.403560e-01 0.9196239568 7 5320532 5320607 76 - 1.978 1.959 -0.064
ENSG00000182095 E021 0.5668842 0.4364212458 8.810636e-01   7 5320608 5320662 55 - 0.175 0.159 -0.164
ENSG00000182095 E022 108.1220259 0.0009355116 7.767310e-01 0.8827447707 7 5321073 5321190 118 - 2.007 1.996 -0.038
ENSG00000182095 E023 53.4086095 0.0049888468 4.972744e-01 0.6990962229 7 5324214 5324221 8 - 1.729 1.692 -0.126
ENSG00000182095 E024 61.1617270 0.0010889361 8.750462e-01 0.9387216929 7 5324222 5324246 25 - 1.752 1.762 0.034
ENSG00000182095 E025 104.1087468 0.0028752142 8.358217e-01 0.9170725907 7 5324247 5324355 109 - 1.988 1.978 -0.035
ENSG00000182095 E026 96.9963261 0.0005603881 4.573002e-01 0.6712766154 7 5325096 5325248 153 - 1.971 1.943 -0.095
ENSG00000182095 E027 2.6419862 0.0498375107 6.950305e-01 0.8323206984 7 5325249 5325574 326 - 0.476 0.547 0.344
ENSG00000182095 E028 8.8193363 0.0059785735 4.270259e-01 0.6487553047 7 5329937 5329969 33 - 1.017 0.923 -0.352
ENSG00000182095 E029 116.0132522 0.0004973755 3.135124e-05 0.0005610007 7 5332622 5333049 428 - 1.910 2.071 0.540
ENSG00000182095 E030 126.2316735 0.0004351149 1.349299e-02 0.0723530360 7 5345562 5345810 249 - 2.002 2.092 0.300
ENSG00000182095 E031 173.4968708 0.0033652402 8.735247e-02 0.2588955920 7 5351819 5352001 183 - 2.249 2.178 -0.237
ENSG00000182095 E032 142.9732146 0.0028179938 7.008077e-02 0.2249650703 7 5352002 5352094 93 - 2.168 2.092 -0.254
ENSG00000182095 E033 253.5963549 0.0002715035 2.311152e-05 0.0004324446 7 5356916 5357276 361 - 2.436 2.335 -0.336
ENSG00000182095 E034 147.5770794 0.0015258369 1.830294e-03 0.0159169440 7 5359398 5359569 172 - 2.211 2.102 -0.365
ENSG00000182095 E035 96.3713805 0.0046711349 1.747758e-02 0.0872164676 7 5361594 5361722 129 - 2.032 1.915 -0.394
ENSG00000182095 E036 131.1202941 0.0035857124 8.261183e-01 0.9115541499 7 5361897 5362033 137 - 2.091 2.082 -0.030
ENSG00000182095 E037 133.2828144 0.0005781266 7.804513e-01 0.8850362356 7 5362650 5362825 176 - 2.098 2.089 -0.030
ENSG00000182095 E038 378.0276156 0.0005280202 5.453329e-03 0.0369842453 7 5370375 5371364 990 - 2.583 2.524 -0.195
ENSG00000182095 E039 77.0189314 0.0040750756 6.260624e-01 0.7879918238 7 5374055 5374481 427 - 1.874 1.852 -0.074
ENSG00000182095 E040 29.1674781 0.0023817558 3.480898e-01 0.5855562117 7 5374482 5374484 3 - 1.494 1.431 -0.219
ENSG00000182095 E041 46.3896376 0.0013720449 6.172171e-01 0.7819121323 7 5376034 5376113 80 - 1.663 1.637 -0.091
ENSG00000182095 E042 69.7623873 0.0006124483 8.292841e-01 0.9133949676 7 5376114 5376224 111 - 1.822 1.813 -0.030
ENSG00000182095 E043 90.0394226 0.0006416947 9.465771e-01 0.9755971087 7 5376847 5376993 147 - 1.923 1.920 -0.009
ENSG00000182095 E044 97.5252912 0.0005358220 3.991282e-01 0.6275160473 7 5377371 5377576 206 - 1.978 1.945 -0.110
ENSG00000182095 E045 92.8718904 0.0019884516 9.971304e-02 0.2812371155 7 5377922 5378024 103 - 1.983 1.910 -0.244
ENSG00000182095 E046 266.2909201 0.0002312809 6.275464e-01 0.7889224117 7 5387672 5389304 1633 - 2.397 2.387 -0.035
ENSG00000182095 E047 27.4514769 0.0014670451 5.942215e-02 0.2015146111 7 5389305 5389336 32 - 1.508 1.378 -0.448
ENSG00000182095 E048 1.7772088 0.4129691745 3.188453e-01 0.5585992454 7 5389450 5390484 1035 - 0.177 0.489 2.055
ENSG00000182095 E049 65.2595244 0.0007184503 4.766673e-03 0.0333640278 7 5390485 5390628 144 - 1.874 1.745 -0.436
ENSG00000182095 E050 58.7537698 0.0064053608 1.606524e-01 0.3777533121 7 5394440 5394595 156 - 1.801 1.716 -0.289
ENSG00000182095 E051 0.5649788 0.0244375199 1.998538e-01   7 5407150 5407394 245 - 0.000 0.264 11.731
ENSG00000182095 E052 31.5408532 0.0164193441 1.394945e-01 0.3467212098 7 5421060 5421489 430 - 1.376 1.513 0.473
ENSG00000182095 E053 4.5363559 0.0125838490 5.738146e-01 0.7528637887 7 5421830 5422032 203 - 0.775 0.697 -0.318
ENSG00000182095 E054 23.5859009 0.2888244854 2.589197e-01 0.4977588499 7 5423441 5423834 394 - 1.188 1.406 0.765
ENSG00000182095 E055 1.0295171 0.0180219977 3.119546e-01   7 5425291 5425414 124 - 0.395 0.213 -1.233