ENSG00000182087

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356663 ENSG00000182087 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM259 protein_coding protein_coding 152.0845 224.8131 114.6268 18.98202 2.228534 -0.9717207 88.89641 137.180339 57.368171 19.229157 1.3967336 -1.2576050 0.5768458 0.60493333 0.50046667 -0.10446667 0.41337407 0.00197618 FALSE  
ENST00000586285 ENSG00000182087 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM259 protein_coding protein_coding 152.0845 224.8131 114.6268 18.98202 2.228534 -0.9717207 17.77609 24.880513 16.688344 1.504278 0.9786015 -0.5758909 0.1196208 0.11120000 0.14586667 0.03466667 0.36130788 0.00197618 FALSE  
ENST00000589055 ENSG00000182087 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM259 protein_coding retained_intron 152.0845 224.8131 114.6268 18.98202 2.228534 -0.9717207 14.86142 17.830063 14.798759 4.348896 0.6495980 -0.2686700 0.1038333 0.08193333 0.12916667 0.04723333 0.52222025 0.00197618 TRUE  
ENST00000607316 ENSG00000182087 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM259 protein_coding retained_intron 152.0845 224.8131 114.6268 18.98202 2.228534 -0.9717207 3.93652 5.370646 8.777097 1.072421 0.5948706 0.7076072 0.0284375 0.02440000 0.07646667 0.05206667 0.00197618 0.00197618 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000182087 E001 2.661458 0.0088831812 3.503133e-01 5.875246e-01 19 1009185 1009377 193 - 0.616 0.504 -0.513
ENSG00000182087 E002 4.525463 0.0290365392 4.224371e-02 1.605445e-01 19 1009378 1009647 270 - 0.889 0.622 -1.083
ENSG00000182087 E003 3.392604 0.0201944074 1.268783e-01 3.268142e-01 19 1009648 1009649 2 - 0.754 0.555 -0.855
ENSG00000182087 E004 3.422344 0.0171824412 2.631522e-01 5.023696e-01 19 1009650 1009650 1 - 0.713 0.578 -0.579
ENSG00000182087 E005 7.202902 0.0044482250 8.828906e-01 9.427885e-01 19 1009651 1009651 1 - 0.828 0.901 0.281
ENSG00000182087 E006 9.466628 0.0040007402 5.719445e-01 7.516587e-01 19 1009652 1009652 1 - 0.891 1.015 0.465
ENSG00000182087 E007 36.772906 0.2959080028 2.752163e-01 5.152471e-01 19 1009653 1009699 47 - 1.335 1.583 0.854
ENSG00000182087 E008 187.389209 1.0996240845 4.251459e-01 6.473613e-01 19 1009700 1009719 20 - 2.024 2.281 0.860
ENSG00000182087 E009 888.604803 0.0053142275 2.930241e-06 7.286899e-05 19 1009720 1009861 142 - 2.719 2.952 0.776
ENSG00000182087 E010 1978.330544 0.0058098085 5.106405e-05 8.474150e-04 19 1009862 1010176 315 - 3.092 3.292 0.664
ENSG00000182087 E011 2302.172453 0.1331544908 5.167669e-02 1.836883e-01 19 1010177 1010694 518 - 3.059 3.378 1.060
ENSG00000182087 E012 1159.992938 0.1260652745 6.815518e-02 2.209360e-01 19 1010695 1010895 201 - 2.775 3.078 1.006
ENSG00000182087 E013 15.046084 0.0592971198 8.955843e-01 9.495077e-01 19 1010896 1010990 95 - 1.129 1.168 0.137
ENSG00000182087 E014 38.154734 0.0329755636 8.063857e-01 8.999593e-01 19 1010991 1011095 105 - 1.517 1.551 0.117
ENSG00000182087 E015 974.187556 0.0271487973 2.440932e-01 4.811501e-01 19 1011096 1011195 100 - 2.839 2.971 0.439
ENSG00000182087 E016 111.445078 0.0244791070 4.218197e-02 1.603929e-01 19 1011196 1011366 171 - 2.077 1.970 -0.357
ENSG00000182087 E017 1106.182970 0.0005608888 1.521142e-01 3.654697e-01 19 1011367 1011499 133 - 2.969 3.006 0.121
ENSG00000182087 E018 33.366038 0.0085125598 7.091797e-01 8.412206e-01 19 1011500 1011579 80 - 1.424 1.513 0.306
ENSG00000182087 E019 632.303352 0.0103562781 1.533273e-01 3.671117e-01 19 1011580 1011612 33 - 2.763 2.747 -0.052
ENSG00000182087 E020 495.052917 0.0041826573 9.900571e-02 2.800380e-01 19 1011613 1011663 51 - 2.646 2.646 -0.001
ENSG00000182087 E021 62.773214 0.0552336168 8.674586e-01 9.345435e-01 19 1011664 1011740 77 - 1.688 1.778 0.303
ENSG00000182087 E022 686.651357 0.0031533790 6.953367e-03 4.441592e-02 19 1011741 1011798 58 - 2.805 2.781 -0.081
ENSG00000182087 E023 8.172811 0.0849773815 4.337710e-01 6.540587e-01 19 1011852 1011865 14 - 0.976 0.885 -0.342
ENSG00000182087 E024 9.108647 0.0991704162 5.507513e-01 7.368705e-01 19 1011866 1011891 26 - 1.002 0.931 -0.263
ENSG00000182087 E025 996.788627 0.0056548147 4.886872e-03 3.401243e-02 19 1011892 1011992 101 - 2.983 2.935 -0.157
ENSG00000182087 E026 909.990923 0.0030986408 9.838733e-05 1.475003e-03 19 1012066 1012112 47 - 2.949 2.894 -0.182
ENSG00000182087 E027 966.059553 0.0029359444 5.780268e-05 9.443852e-04 19 1012113 1012188 76 - 2.975 2.920 -0.184
ENSG00000182087 E028 251.677108 0.0650236113 5.583576e-02 1.932539e-01 19 1012189 1012462 274 - 2.457 2.306 -0.505
ENSG00000182087 E029 985.302131 0.0048647296 1.362772e-02 7.288354e-02 19 1012463 1012540 78 - 2.964 2.936 -0.095
ENSG00000182087 E030 761.935645 0.0037601080 7.749656e-03 4.813012e-02 19 1012541 1012573 33 - 2.853 2.825 -0.093
ENSG00000182087 E031 1048.777211 0.0024699113 3.037071e-04 3.766438e-03 19 1013241 1013340 100 - 2.997 2.961 -0.119
ENSG00000182087 E032 31.790350 0.0087876360 2.232729e-02 1.036773e-01 19 1013341 1013358 18 - 1.555 1.433 -0.421
ENSG00000182087 E033 17.333817 0.0959183844 1.542617e-01 3.683530e-01 19 1013359 1013639 281 - 1.321 1.165 -0.551
ENSG00000182087 E034 1068.274566 0.0032361452 1.659174e-05 3.258539e-04 19 1014192 1014317 126 - 3.027 2.960 -0.223
ENSG00000182087 E035 1092.544260 0.0068339617 6.636605e-04 7.127352e-03 19 1014318 1014473 156 - 3.045 2.965 -0.266
ENSG00000182087 E036 4.347279 0.1883860676 5.800787e-01 7.572201e-01 19 1017279 1017420 142 - 0.711 0.682 -0.124
ENSG00000182087 E037 755.251542 0.0067862604 1.809177e-02 8.932689e-02 19 1020772 1021179 408 - 2.858 2.817 -0.136