ENSG00000181666

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392153 ENSG00000181666 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF875 protein_coding protein_coding 9.582084 11.28265 9.0918 1.189454 0.1593377 -0.3111609 0.7201173 1.12078744 0.9197167 0.64494715 0.59696066 -0.28246475 0.09007500 0.114466667 0.10320000 -0.01126667 1.000000000 0.002232587 FALSE  
ENST00000544914 ENSG00000181666 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF875 protein_coding protein_coding 9.582084 11.28265 9.0918 1.189454 0.1593377 -0.3111609 0.5767639 0.82592135 0.2928109 0.17529771 0.15030751 -1.46495027 0.06408333 0.077800000 0.03176667 -0.04603333 0.675095644 0.002232587 FALSE  
ENST00000588820 ENSG00000181666 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF875 protein_coding retained_intron 9.582084 11.28265 9.0918 1.189454 0.1593377 -0.3111609 0.9254923 0.55843834 1.2478162 0.41314521 0.66034562 1.14584534 0.08081250 0.045966667 0.13513333 0.08916667 0.864036515 0.002232587 FALSE  
ENST00000589188 ENSG00000181666 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF875 protein_coding protein_coding 9.582084 11.28265 9.0918 1.189454 0.1593377 -0.3111609 0.1446529 0.09579081 0.6382482 0.05048471 0.26339507 2.61533203 0.01627500 0.007766667 0.06926667 0.06150000 0.115356121 0.002232587    
ENST00000589218 ENSG00000181666 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF875 protein_coding processed_transcript 9.582084 11.28265 9.0918 1.189454 0.1593377 -0.3111609 0.6917976 0.61010545 0.2790930 0.33828158 0.09430832 -1.10097968 0.07078333 0.048600000 0.03086667 -0.01773333 1.000000000 0.002232587    
ENST00000590166 ENSG00000181666 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF875 protein_coding protein_coding 9.582084 11.28265 9.0918 1.189454 0.1593377 -0.3111609 0.6562623 1.06567125 0.6452995 0.24467449 0.12298908 -0.71501087 0.05932500 0.092800000 0.07070000 -0.02210000 0.806370730 0.002232587    
MSTRG.17066.12 ENSG00000181666 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF875 protein_coding   9.582084 11.28265 9.0918 1.189454 0.1593377 -0.3111609 0.6262231 0.75280248 0.6294234 0.10375710 0.10516393 -0.25453806 0.06373333 0.067433333 0.06893333 0.00150000 1.000000000 0.002232587    
MSTRG.17066.19 ENSG00000181666 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF875 protein_coding   9.582084 11.28265 9.0918 1.189454 0.1593377 -0.3111609 0.2475568 0.58215747 0.0000000 0.21685181 0.00000000 -5.88790898 0.02590417 0.055400000 0.00000000 -0.05540000 0.008659243 0.002232587 FALSE  
MSTRG.17066.21 ENSG00000181666 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF875 protein_coding   9.582084 11.28265 9.0918 1.189454 0.1593377 -0.3111609 0.8335433 1.42982569 1.3379678 0.67110788 0.19891012 -0.09510809 0.07975000 0.116133333 0.14670000 0.03056667 0.880587775 0.002232587 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

No results under this category.

Splicing

All exons whithin this gene region are shown and numbering below.

No results under this category.

Transcripts

All isoforms whithin this gene region are shown below.

No results under this category.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000181666 E001 0.0000000       19 37312837 37312877 41 +      
ENSG00000181666 E002 0.0000000       19 37312878 37313312 435 +      
ENSG00000181666 E003 0.0000000       19 37316995 37317142 148 +      
ENSG00000181666 E004 0.1308682 0.033646333 1.00000000   19 37317887 37317899 13 +      
ENSG00000181666 E005 0.5767453 0.020369737 0.70144858   19 37317900 37317903 4 +      
ENSG00000181666 E006 0.5767453 0.020369737 0.70144858   19 37317904 37317904 1 +      
ENSG00000181666 E007 2.3987259 0.008916486 0.21992483 0.45341008 19 37317905 37317910 6 +      
ENSG00000181666 E008 2.7019684 0.008258463 0.12632677 0.32598687 19 37317911 37317914 4 +      
ENSG00000181666 E009 3.2247009 0.007286834 0.16022567 0.37714594 19 37317915 37317916 2 +      
ENSG00000181666 E010 3.5583033 0.006639480 0.09419796 0.27153567 19 37317917 37317918 2 +      
ENSG00000181666 E011 6.3718833 0.011774756 0.78927302 0.89004755 19 37317919 37317930 12 +      
ENSG00000181666 E012 15.4745133 0.002761205 0.81381526 0.90456883 19 37317931 37318038 108 +      
ENSG00000181666 E013 11.9450405 0.098183292 0.83225365 0.91511744 19 37318039 37318079 41 +      
ENSG00000181666 E014 21.5145231 0.003598955 0.77863623 0.88392811 19 37318080 37318186 107 +      
ENSG00000181666 E015 10.5060468 0.030642080 0.22758981 0.46247528 19 37322185 37322232 48 +      
ENSG00000181666 E016 12.6382508 0.009459050 0.14604335 0.35643585 19 37323533 37323570 38 +      
ENSG00000181666 E017 16.9002281 0.043053950 0.02703591 0.11841539 19 37324208 37324265 58 +      
ENSG00000181666 E018 11.3959847 0.039276877 0.01537017 0.07947291 19 37324796 37324936 141 +      
ENSG00000181666 E019 7.1100082 0.054597089 0.11076863 0.30026116 19 37324937 37325077 141 +      
ENSG00000181666 E020 3.8323218 0.008619154 0.09074575 0.26513060 19 37325078 37325101 24 +      
ENSG00000181666 E021 4.5457324 0.007290971 0.04375440 0.16448993 19 37325102 37325128 27 +      
ENSG00000181666 E022 3.6947467 0.009612043 0.09133619 0.26614686 19 37325129 37325153 25 +      
ENSG00000181666 E023 9.2766152 0.036528907 0.26744167 0.50709093 19 37325154 37325274 121 +      
ENSG00000181666 E024 20.2055916 0.113414739 0.90877497 0.95645613 19 37328579 37329024 446 +      
ENSG00000181666 E025 6.8519691 0.232619400 0.62889325 0.78974829 19 37329025 37329064 40 +      
ENSG00000181666 E026 6.1195375 0.078277905 0.22609437 0.46070438 19 37329065 37329105 41 +      
ENSG00000181666 E027 8.3455585 0.047081787 0.01033596 0.05956982 19 37329172 37329245 74 +      
ENSG00000181666 E028 0.4929928 0.023065816 0.26104185   19 37334624 37334639 16 +      
ENSG00000181666 E029 0.4929928 0.023065816 0.26104185   19 37334640 37334648 9 +      
ENSG00000181666 E030 0.4929928 0.023065816 0.26104185   19 37334649 37334655 7 +      
ENSG00000181666 E031 0.4929928 0.023065816 0.26104185   19 37334656 37334656 1 +      
ENSG00000181666 E032 0.4929928 0.023065816 0.26104185   19 37334657 37334657 1 +      
ENSG00000181666 E033 2.6125068 0.075629031 0.24784634 0.48566551 19 37334658 37334670 13 +      
ENSG00000181666 E034 2.7904907 0.149718785 0.21705933 0.44992208 19 37334671 37334677 7 +      
ENSG00000181666 E035 5.6438259 0.066867408 0.89068012 0.94701367 19 37334678 37334711 34 +      
ENSG00000181666 E036 5.9490936 0.102421793 0.75233578 0.86812064 19 37334712 37334727 16 +      
ENSG00000181666 E037 7.0681604 0.056380198 0.94798106 0.97624699 19 37334728 37334782 55 +      
ENSG00000181666 E038 2.8055812 0.186625019 0.21796688 0.45101056 19 37334783 37335168 386 +      
ENSG00000181666 E039 4.7516415 0.054169762 0.46465462 0.67633229 19 37335169 37335199 31 +      
ENSG00000181666 E040 6.8925955 0.096724156 0.96846592 0.98607703 19 37335200 37335257 58 +      
ENSG00000181666 E041 5.9030116 0.074347886 0.30073872 0.54121560 19 37344610 37344774 165 +      
ENSG00000181666 E042 6.4762900 0.105901758 0.14846891 0.36007373 19 37344775 37344933 159 +      
ENSG00000181666 E043 4.6779330 0.089689407 0.65384079 0.80599222 19 37344934 37345021 88 +      
ENSG00000181666 E044 2.8805878 0.008517935 0.18533920 0.41100624 19 37346297 37346355 59 +      
ENSG00000181666 E045 2.1194413 0.019603438 0.78804805 0.88939752 19 37346356 37346422 67 +      
ENSG00000181666 E046 2.3514379 0.009527072 0.92420166 0.96448534 19 37346423 37346492 70 +      
ENSG00000181666 E047 2.5790536 0.501207528 0.85420500 0.92719685 19 37346493 37346675 183 +      
ENSG00000181666 E048 4.1025437 0.134813705 0.92948353 0.96675373 19 37346772 37346887 116 +      
ENSG00000181666 E049 7.4727123 0.004806568 0.56517528 0.74684494 19 37346888 37347052 165 +      
ENSG00000181666 E050 6.4548391 0.016809444 0.62997547 0.79040970 19 37347053 37347189 137 +      
ENSG00000181666 E051 14.5792882 0.039961653 0.36567075 0.60049546 19 37347190 37347206 17 +      
ENSG00000181666 E052 12.5919275 0.012537282 0.44737895 0.66378324 19 37347207 37347231 25 +      
ENSG00000181666 E053 17.9922433 0.001923499 0.27998701 0.52007627 19 37347232 37347316 85 +      
ENSG00000181666 E054 1.4503836 0.400713500 0.70320158 0.83764573 19 37347563 37347776 214 +      
ENSG00000181666 E055 26.2523655 0.001762008 0.88612649 0.94462051 19 37347777 37347872 96 +      
ENSG00000181666 E056 1.6369120 0.073977716 0.13831882 0.34498692 19 37357962 37358039 78 +      
ENSG00000181666 E057 0.2027342 0.048441644 1.00000000   19 37358541 37358546 6 +      
ENSG00000181666 E058 0.2027342 0.048441644 1.00000000   19 37358547 37358661 115 +      
ENSG00000181666 E059 3.2157675 0.007887066 0.15739090 0.37282014 19 37359426 37359546 121 +      
ENSG00000181666 E060 2.9345150 0.067699656 0.34759434 0.58500667 19 37359547 37359776 230 +      
ENSG00000181666 E061 0.7558267 0.127658201 0.72706382   19 37361968 37362105 138 +      
ENSG00000181666 E062 3.6536500 0.007318178 0.68794978 0.82779270 19 37362106 37362108 3 +      
ENSG00000181666 E063 319.2946634 0.231286561 0.42530401 0.64747302 19 37362109 37364455 2347 +      
ENSG00000181666 E064 0.5823548 0.112389263 0.52655495   19 37369179 37369365 187 +