ENSG00000181555

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409792 ENSG00000181555 HEK293_OSMI2_6hA HEK293_TMG_6hB SETD2 protein_coding protein_coding 20.30656 20.16245 26.11929 5.431591 0.7056797 0.3732812 7.9955247 2.9881277 15.7767577 0.7025785 0.9393671 2.3965811 0.34915417 0.15846667 0.603300000 0.44483333 9.064819e-11 7.500003e-32 FALSE TRUE
ENST00000685005 ENSG00000181555 HEK293_OSMI2_6hA HEK293_TMG_6hB SETD2 protein_coding protein_coding 20.30656 20.16245 26.11929 5.431591 0.7056797 0.3732812 1.7398118 1.7336704 2.8478803 0.5258474 0.8191202 0.7128181 0.07834583 0.08556667 0.110866667 0.02530000 9.345713e-01 7.500003e-32 FALSE TRUE
ENST00000686773 ENSG00000181555 HEK293_OSMI2_6hA HEK293_TMG_6hB SETD2 protein_coding nonsense_mediated_decay 20.30656 20.16245 26.11929 5.431591 0.7056797 0.3732812 0.9373977 0.2851141 1.8326867 0.2851141 0.0593849 2.6424662 0.04582083 0.01110000 0.070400000 0.05930000 1.891010e-01 7.500003e-32 TRUE TRUE
ENST00000687657 ENSG00000181555 HEK293_OSMI2_6hA HEK293_TMG_6hB SETD2 protein_coding retained_intron 20.30656 20.16245 26.11929 5.431591 0.7056797 0.3732812 1.9127822 2.5184318 0.2105398 0.5870772 0.1259329 -3.5191322 0.12110833 0.13276667 0.008166667 -0.12460000 5.203215e-03 7.500003e-32 FALSE TRUE
ENST00000690157 ENSG00000181555 HEK293_OSMI2_6hA HEK293_TMG_6hB SETD2 protein_coding protein_coding 20.30656 20.16245 26.11929 5.431591 0.7056797 0.3732812 0.7354818 2.4497844 0.2383665 1.0465144 0.1220651 -3.3079893 0.03990000 0.10650000 0.009200000 -0.09730000 8.331084e-02 7.500003e-32 FALSE TRUE
ENST00000691544 ENSG00000181555 HEK293_OSMI2_6hA HEK293_TMG_6hB SETD2 protein_coding protein_coding 20.30656 20.16245 26.11929 5.431591 0.7056797 0.3732812 2.9166354 6.3743080 0.0000000 2.0224058 0.0000000 -9.3183864 0.16501667 0.30230000 0.000000000 -0.30230000 7.500003e-32 7.500003e-32 FALSE TRUE
ENST00000692362 ENSG00000181555 HEK293_OSMI2_6hA HEK293_TMG_6hB SETD2 protein_coding retained_intron 20.30656 20.16245 26.11929 5.431591 0.7056797 0.3732812 0.8691124 1.7261691 0.0000000 0.4019353 0.0000000 -7.4397637 0.04780000 0.08876667 0.000000000 -0.08876667 4.339218e-19 7.500003e-32 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000181555 E001 0.1426347 0.0340185854 7.607232e-01   3 47016428 47016428 1 - 0.100 0.000 -9.794
ENSG00000181555 E002 0.2735028 0.0252321462 7.638253e-01   3 47016429 47016435 7 - 0.100 0.146 0.622
ENSG00000181555 E003 1.2142104 0.0247030377 5.304257e-02   3 47016436 47016442 7 - 0.182 0.531 2.206
ENSG00000181555 E004 1.4169446 0.0234353944 2.604240e-02 1.154485e-01 3 47016443 47016444 2 - 0.182 0.580 2.431
ENSG00000181555 E005 102.6496457 0.0010539925 8.869385e-16 1.498732e-13 3 47016445 47016688 244 - 1.857 2.165 1.033
ENSG00000181555 E006 541.1136631 0.0005695409 3.873638e-32 3.737686e-29 3 47016689 47017254 566 - 2.626 2.845 0.728
ENSG00000181555 E007 264.2627801 0.0023001344 1.308488e-07 4.732938e-06 3 47017638 47017739 102 - 2.343 2.511 0.560
ENSG00000181555 E008 222.5088486 0.0002846628 6.880796e-09 3.345467e-07 3 47019760 47019840 81 - 2.280 2.429 0.499
ENSG00000181555 E009 0.7145081 0.0225303720 6.777203e-01   3 47028228 47028308 81 - 0.182 0.256 0.625
ENSG00000181555 E010 0.9513064 0.0742798625 2.365497e-01   3 47037665 47037665 1 - 0.183 0.413 1.602
ENSG00000181555 E011 201.7832464 0.0018074089 4.710947e-04 5.412904e-03 3 47037666 47037777 112 - 2.251 2.371 0.402
ENSG00000181555 E012 2.9397621 0.0091185109 1.435517e-02 7.571160e-02 3 47041360 47041483 124 - 0.408 0.792 1.737
ENSG00000181555 E013 196.0084209 0.0002588084 5.943675e-09 2.924023e-07 3 47042561 47042700 140 - 2.218 2.376 0.527
ENSG00000181555 E014 190.6381716 0.0002446789 1.835224e-12 1.798403e-10 3 47046487 47046621 135 - 2.189 2.380 0.639
ENSG00000181555 E015 1.1386556 0.0911844110 1.940819e-01   3 47046622 47047027 406 - 0.409 0.147 -1.961
ENSG00000181555 E016 451.7074281 0.0010234045 1.309401e-09 7.484562e-08 3 47056821 47057490 670 - 2.586 2.727 0.470
ENSG00000181555 E017 0.0000000       3 47061401 47061494 94 -      
ENSG00000181555 E018 0.1723744 0.1246040203 3.208299e-01   3 47062160 47062162 3 - 0.000 0.147 11.242
ENSG00000181555 E019 209.1366083 0.0002530559 3.141175e-03 2.425185e-02 3 47062163 47062346 184 - 2.283 2.366 0.276
ENSG00000181555 E020 0.8628224 0.1846077713 3.218095e-01   3 47064555 47064630 76 - 0.357 0.145 -1.688
ENSG00000181555 E021 112.2110987 0.0011942245 8.169935e-01 9.064344e-01 3 47067070 47067118 49 - 2.044 2.062 0.062
ENSG00000181555 E022 1.1472137 0.0151500894 8.688309e-01   3 47067119 47067397 279 - 0.310 0.343 0.209
ENSG00000181555 E023 1.4810038 0.0127580262 7.736526e-01 8.809013e-01 3 47073005 47073147 143 - 0.362 0.415 0.302
ENSG00000181555 E024 3.8400267 0.0098462174 5.474144e-01 7.344195e-01 3 47079512 47079611 100 - 0.641 0.733 0.385
ENSG00000181555 E025 1.7594959 0.1228257537 7.020775e-01 8.368968e-01 3 47079612 47079739 128 - 0.409 0.476 0.345
ENSG00000181555 E026 16.6090666 0.0644660348 9.115782e-01 9.579502e-01 3 47079740 47080800 1061 - 1.241 1.209 -0.113
ENSG00000181555 E027 10.2164131 0.0029979190 5.314571e-01 7.230356e-01 3 47080801 47080898 98 - 1.067 1.009 -0.212
ENSG00000181555 E028 5.2680181 0.0048118625 9.551295e-01 9.794865e-01 3 47080899 47080915 17 - 0.792 0.793 0.001
ENSG00000181555 E029 16.1620001 0.0168614332 3.741372e-01 6.074409e-01 3 47080916 47081083 168 - 1.257 1.167 -0.318
ENSG00000181555 E030 444.5727168 0.0001528125 3.005424e-01 5.410056e-01 3 47083720 47084382 663 - 2.631 2.657 0.087
ENSG00000181555 E031 124.8727393 0.0082563182 4.475208e-01 6.639235e-01 3 47086195 47086314 120 - 2.076 2.112 0.122
ENSG00000181555 E032 3.7759128 0.0198746553 7.192353e-01 8.476775e-01 3 47086315 47086698 384 - 0.642 0.700 0.242
ENSG00000181555 E033 110.1685438 0.0040873231 8.663099e-01 9.339428e-01 3 47088113 47088183 71 - 2.033 2.043 0.033
ENSG00000181555 E034 117.7237325 0.0048119682 3.598263e-01 5.956378e-01 3 47088184 47088247 64 - 2.082 2.039 -0.143
ENSG00000181555 E035 194.1776061 0.0034152724 7.019221e-01 8.367917e-01 3 47097955 47098081 127 - 2.284 2.275 -0.029
ENSG00000181555 E036 2.7693085 0.0609166992 8.059487e-01 8.996879e-01 3 47098082 47099940 1859 - 0.588 0.532 -0.255
ENSG00000181555 E037 180.5706368 0.0020640226 2.894536e-02 1.241969e-01 3 47101458 47101555 98 - 2.275 2.207 -0.228
ENSG00000181555 E038 142.7030717 0.0002947436 6.315387e-02 2.097947e-01 3 47103346 47103423 78 - 2.168 2.120 -0.162
ENSG00000181555 E039 151.0817473 0.0004037103 3.485145e-01 5.859509e-01 3 47105997 47106120 124 - 2.185 2.166 -0.064
ENSG00000181555 E040 148.6509335 0.0031834686 8.013035e-01 8.970821e-01 3 47113876 47114004 129 - 2.169 2.173 0.014
ENSG00000181555 E041 131.0713622 0.0009346446 5.983823e-01 7.691507e-01 3 47116623 47116754 132 - 2.119 2.112 -0.024
ENSG00000181555 E042 0.0000000       3 47116755 47117013 259 -      
ENSG00000181555 E043 0.0000000       3 47119452 47119780 329 -      
ENSG00000181555 E044 173.2734497 0.0003025818 2.446971e-02 1.105614e-01 3 47120182 47120482 301 - 2.256 2.202 -0.180
ENSG00000181555 E045 896.7712324 0.0001332063 1.725802e-59 9.454222e-56 3 47120483 47122799 2317 - 3.014 2.818 -0.652
ENSG00000181555 E046 539.9136749 0.0001957623 2.062788e-100 7.006178e-96 3 47122800 47124548 1749 - 2.837 2.472 -1.217
ENSG00000181555 E047 27.1819041 0.0013268466 4.938539e-06 1.139198e-04 3 47126648 47126663 16 - 1.548 1.220 -1.136
ENSG00000181555 E048 0.1308682 0.0326491905 3.215035e-01   3 47163428 47163576 149 - 0.000 0.146 11.848
ENSG00000181555 E049 29.8353285 0.0119616314 4.699048e-02 1.725270e-01 3 47163854 47164113 260 - 1.543 1.379 -0.564