ENSG00000181513

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376955 ENSG00000181513 HEK293_OSMI2_6hA HEK293_TMG_6hB ACBD4 protein_coding protein_coding 3.987306 5.591782 2.131265 0.3189936 0.3211042 -1.387423 0.6647175 0.8531819 0.26801447 0.1697536 0.08321902 -1.6345046 0.16230417 0.15343333 0.12396667 -0.02946667 0.92147742 0.00871914 FALSE  
ENST00000398322 ENSG00000181513 HEK293_OSMI2_6hA HEK293_TMG_6hB ACBD4 protein_coding protein_coding 3.987306 5.591782 2.131265 0.3189936 0.3211042 -1.387423 1.0849214 1.5277173 0.74239289 0.1920570 0.08037672 -1.0312321 0.29225417 0.27863333 0.36436667 0.08573333 0.80825626 0.00871914 FALSE  
ENST00000585553 ENSG00000181513 HEK293_OSMI2_6hA HEK293_TMG_6hB ACBD4 protein_coding retained_intron 3.987306 5.591782 2.131265 0.3189936 0.3211042 -1.387423 0.3463206 0.4404591 0.33753352 0.3798038 0.10817870 -0.3742441 0.09570417 0.08220000 0.15680000 0.07460000 0.57938631 0.00871914 FALSE  
ENST00000586346 ENSG00000181513 HEK293_OSMI2_6hA HEK293_TMG_6hB ACBD4 protein_coding protein_coding 3.987306 5.591782 2.131265 0.3189936 0.3211042 -1.387423 0.6517504 0.8910373 0.11173850 0.4581815 0.11173850 -2.8878013 0.15351667 0.15433333 0.07380000 -0.08053333 0.77165494 0.00871914 FALSE  
ENST00000590289 ENSG00000181513 HEK293_OSMI2_6hA HEK293_TMG_6hB ACBD4 protein_coding retained_intron 3.987306 5.591782 2.131265 0.3189936 0.3211042 -1.387423 0.2452577 0.5323408 0.30637944 0.2897751 0.15323289 -0.7775438 0.06264167 0.09133333 0.12596667 0.03463333 0.96183966 0.00871914    
ENST00000591859 ENSG00000181513 HEK293_OSMI2_6hA HEK293_TMG_6hB ACBD4 protein_coding protein_coding 3.987306 5.591782 2.131265 0.3189936 0.3211042 -1.387423 0.2422503 0.5338950 0.00000000 0.1594091 0.00000000 -5.7652563 0.05034167 0.09500000 0.00000000 -0.09500000 0.00871914 0.00871914 FALSE  
MSTRG.14489.1 ENSG00000181513 HEK293_OSMI2_6hA HEK293_TMG_6hB ACBD4 protein_coding   3.987306 5.591782 2.131265 0.3189936 0.3211042 -1.387423 0.2325369 0.3296721 0.05686025 0.1812049 0.03385914 -2.3449222 0.05366667 0.05643333 0.02883333 -0.02760000 0.95403457 0.00871914 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000181513 E001 0.0000000       17 45132600 45132604 5 +      
ENSG00000181513 E002 0.2617363 0.1623809472 1.000000000   17 45132605 45132628 24 + 0.000 0.127 9.032
ENSG00000181513 E003 0.8985812 0.0183685171 0.165531324   17 45132629 45132630 2 + 0.000 0.310 12.745
ENSG00000181513 E004 1.4939199 0.1009481620 0.072475866 0.22973761 17 45132631 45132663 33 + 0.000 0.431 13.181
ENSG00000181513 E005 0.9103477 0.0166717078 0.725231719   17 45133031 45133201 171 + 0.204 0.271 0.537
ENSG00000181513 E006 4.1889234 0.0212520903 0.008029145 0.04944714 17 45135341 45135592 252 + 0.204 0.739 2.903
ENSG00000181513 E007 0.9576510 0.0161189825 0.149785621   17 45135593 45135596 4 + 0.447 0.182 -1.784
ENSG00000181513 E008 1.5354261 0.0133328578 0.047143316 0.17286391 17 45135597 45135646 50 + 0.000 0.437 13.359
ENSG00000181513 E009 1.3630517 0.0560274260 0.075982759   17 45135647 45135648 2 + 0.000 0.406 13.146
ENSG00000181513 E010 2.4470590 0.0089302860 0.096030838 0.27476699 17 45135649 45135686 38 + 0.204 0.536 2.024
ENSG00000181513 E011 2.1549628 0.0101334030 0.152002967 0.36526956 17 45135687 45135687 1 + 0.204 0.490 1.803
ENSG00000181513 E012 2.4166991 0.0087971407 0.096418519 0.27547802 17 45135688 45135689 2 + 0.204 0.536 2.023
ENSG00000181513 E013 2.4885652 0.0089676671 0.095663335 0.27419012 17 45135690 45135693 4 + 0.204 0.536 2.025
ENSG00000181513 E014 3.9890900 0.0072841273 0.750861467 0.86729212 17 45135694 45135706 13 + 0.601 0.651 0.215
ENSG00000181513 E015 14.7147400 0.0621300424 0.161146743 0.37851205 17 45135707 45135838 132 + 1.275 1.072 -0.721
ENSG00000181513 E016 8.9260058 0.0711089294 0.087859639 0.25975501 17 45135839 45135841 3 + 1.130 0.849 -1.043
ENSG00000181513 E017 23.2645967 0.0119595440 0.277643266 0.51772381 17 45135842 45135953 112 + 1.386 1.285 -0.351
ENSG00000181513 E018 11.3896964 0.0187992884 0.085069797 0.25474887 17 45135954 45136095 142 + 1.168 0.958 -0.767
ENSG00000181513 E019 4.2302755 0.0070274331 0.077379736 0.23959994 17 45136096 45136107 12 + 0.844 0.578 -1.104
ENSG00000181513 E020 18.8504746 0.0025463183 0.136402142 0.34200212 17 45136108 45136200 93 + 1.329 1.197 -0.465
ENSG00000181513 E021 14.0531095 0.0028000628 0.994247576 0.99869345 17 45136201 45136232 32 + 1.113 1.107 -0.021
ENSG00000181513 E022 4.0200240 0.2108077031 0.124002463 0.32207375 17 45136233 45136499 267 + 0.851 0.543 -1.291
ENSG00000181513 E023 25.3403560 0.0022195011 0.134872806 0.33949197 17 45136500 45136620 121 + 1.437 1.318 -0.413
ENSG00000181513 E024 8.4384914 0.0334173118 0.261219673 0.50024931 17 45136621 45136691 71 + 1.026 0.853 -0.650
ENSG00000181513 E025 26.0803791 0.0260426781 0.480455236 0.68740027 17 45136692 45136776 85 + 1.422 1.328 -0.327
ENSG00000181513 E026 31.0815937 0.0226237263 0.972550953 0.98824552 17 45137019 45137139 121 + 1.440 1.420 -0.068
ENSG00000181513 E027 28.0949189 0.0016321118 0.949458725 0.97677784 17 45137368 45137454 87 + 1.386 1.385 -0.003
ENSG00000181513 E028 1.0045064 0.7937749666 0.941442377   17 45137455 45137636 182 + 0.200 0.280 0.628
ENSG00000181513 E029 10.6271317 0.0035969008 0.555292766 0.73996770 17 45137722 45137759 38 + 0.944 1.009 0.242
ENSG00000181513 E030 22.1942149 0.0022048816 0.391877445 0.62191428 17 45137760 45137830 71 + 1.234 1.304 0.243
ENSG00000181513 E031 0.2617363 0.1623809472 1.000000000   17 45137831 45137835 5 + 0.000 0.127 11.040
ENSG00000181513 E032 1.7716719 0.0117262082 0.717106314 0.84633860 17 45137910 45137912 3 + 0.342 0.409 0.384
ENSG00000181513 E033 14.0284975 0.0028190259 0.229255422 0.46426554 17 45137913 45137922 10 + 0.999 1.125 0.460
ENSG00000181513 E034 21.5729717 0.0018342869 0.608446632 0.77587243 17 45137923 45137988 66 + 1.249 1.288 0.136
ENSG00000181513 E035 1.2066931 0.0424714235 0.736563407   17 45138276 45138544 269 + 0.343 0.272 -0.461
ENSG00000181513 E036 24.8777210 0.0014814863 0.430852197 0.65177703 17 45139021 45139160 140 + 1.291 1.350 0.205
ENSG00000181513 E037 13.1661087 0.0122998099 0.030070794 0.12754346 17 45142583 45142959 377 + 0.845 1.121 1.027
ENSG00000181513 E038 56.5667779 0.0007477745 0.017442595 0.08708119 17 45143443 45144181 739 + 1.581 1.707 0.427