ENSG00000180902

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321264 ENSG00000180902 HEK293_OSMI2_6hA HEK293_TMG_6hB D2HGDH protein_coding protein_coding 15.07983 24.75702 6.42926 2.068588 0.2940978 -1.943453 6.0719985 10.310694 2.7360259 2.8207183 0.31932723 -1.9101228 0.40229583 0.40356667 0.43203333 0.028466667 9.690915e-01 1.261748e-08 FALSE  
ENST00000403782 ENSG00000180902 HEK293_OSMI2_6hA HEK293_TMG_6hB D2HGDH protein_coding protein_coding 15.07983 24.75702 6.42926 2.068588 0.2940978 -1.943453 1.1037850 2.227316 0.0000000 0.2229497 0.00000000 -7.8056253 0.05374583 0.09130000 0.00000000 -0.091300000 1.261748e-08 1.261748e-08 FALSE  
ENST00000417686 ENSG00000180902 HEK293_OSMI2_6hA HEK293_TMG_6hB D2HGDH protein_coding protein_coding 15.07983 24.75702 6.42926 2.068588 0.2940978 -1.943453 1.0655776 1.981809 1.0184150 0.3260079 0.50978827 -0.9536569 0.08396667 0.08120000 0.15206667 0.070866667 9.886739e-01 1.261748e-08 FALSE  
ENST00000436747 ENSG00000180902 HEK293_OSMI2_6hA HEK293_TMG_6hB D2HGDH protein_coding nonsense_mediated_decay 15.07983 24.75702 6.42926 2.068588 0.2940978 -1.943453 1.2141843 1.926779 0.8199817 0.5040194 0.04987482 -1.2225079 0.09030000 0.08233333 0.12856667 0.046233333 6.334574e-01 1.261748e-08 FALSE  
ENST00000468064 ENSG00000180902 HEK293_OSMI2_6hA HEK293_TMG_6hB D2HGDH protein_coding retained_intron 15.07983 24.75702 6.42926 2.068588 0.2940978 -1.943453 0.8282596 1.572814 0.3382368 0.3937442 0.06462036 -2.1843509 0.05437083 0.06723333 0.05223333 -0.015000000 9.506576e-01 1.261748e-08 FALSE  
ENST00000470343 ENSG00000180902 HEK293_OSMI2_6hA HEK293_TMG_6hB D2HGDH protein_coding retained_intron 15.07983 24.75702 6.42926 2.068588 0.2940978 -1.943453 0.8096670 1.290905 0.3409498 0.5050480 0.04609108 -1.8901788 0.05264167 0.05580000 0.05273333 -0.003066667 9.719900e-01 1.261748e-08 FALSE  
MSTRG.20204.7 ENSG00000180902 HEK293_OSMI2_6hA HEK293_TMG_6hB D2HGDH protein_coding   15.07983 24.75702 6.42926 2.068588 0.2940978 -1.943453 1.0257023 1.380549 0.2599783 0.7194911 0.19398898 -2.3647399 0.05880833 0.05193333 0.03883333 -0.013100000 9.751762e-01 1.261748e-08 FALSE  
MSTRG.20204.8 ENSG00000180902 HEK293_OSMI2_6hA HEK293_TMG_6hB D2HGDH protein_coding   15.07983 24.75702 6.42926 2.068588 0.2940978 -1.943453 0.8369182 1.117219 0.2101975 0.2535130 0.06532571 -2.3558976 0.05557917 0.04466667 0.03253333 -0.012133333 8.198107e-01 1.261748e-08 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000180902 E001 0.0000000       2 241734602 241734614 13 +      
ENSG00000180902 E002 0.0000000       2 241734615 241734616 2 +      
ENSG00000180902 E003 0.5649788 0.0250326366 0.562587207   2 241734617 241734628 12 + 0.000 0.198 9.947
ENSG00000180902 E004 0.7677130 0.0178042883 0.408974673   2 241734629 241734629 1 + 0.000 0.236 12.405
ENSG00000180902 E005 0.7677130 0.0178042883 0.408974673   2 241734630 241734632 3 + 0.000 0.236 12.405
ENSG00000180902 E006 17.2468423 0.0426812880 0.228936783 0.46390792 2 241734633 241734695 63 + 0.983 1.172 0.686
ENSG00000180902 E007 0.8267151 0.2072803264 0.442027249   2 241735132 241735132 1 + 0.000 0.262 12.018
ENSG00000180902 E008 97.0064555 0.3129404620 0.296525034 0.53702194 2 241735133 241735516 384 + 1.715 1.888 0.585
ENSG00000180902 E009 0.9225915 0.2491977080 0.455094511   2 241735945 241736243 299 + 0.000 0.244 11.811
ENSG00000180902 E010 74.9002425 0.0049843302 0.483732720 0.68960763 2 241741033 241741090 58 + 1.715 1.767 0.175
ENSG00000180902 E011 0.1723744 0.0338221763 1.000000000   2 241742433 241742434 2 + 0.000 0.059 10.086
ENSG00000180902 E012 72.2105318 0.0098403431 0.505076027 0.70435618 2 241742435 241742474 40 + 1.772 1.736 -0.121
ENSG00000180902 E013 102.5097469 0.0164484456 0.196697973 0.42540839 2 241742475 241742560 86 + 1.956 1.875 -0.272
ENSG00000180902 E014 60.9459380 0.0165541033 0.119585343 0.31517074 2 241742561 241742574 14 + 1.762 1.647 -0.389
ENSG00000180902 E015 58.2797853 0.0164353499 0.111444328 0.30140480 2 241743622 241743638 17 + 1.745 1.626 -0.406
ENSG00000180902 E016 156.7453787 0.0059501802 0.011586600 0.06475776 2 241743639 241743815 177 + 2.164 2.049 -0.383
ENSG00000180902 E017 145.5645884 0.0054870538 0.106441135 0.29306819 2 241744709 241744877 169 + 2.098 2.026 -0.241
ENSG00000180902 E018 5.8257156 0.0058504406 0.396470850 0.62552718 2 241748827 241748829 3 + 0.588 0.740 0.647
ENSG00000180902 E019 6.3731985 0.0087873234 0.295794293 0.53628999 2 241748830 241748835 6 + 0.588 0.774 0.782
ENSG00000180902 E020 7.2717797 0.0045988906 0.155874401 0.37073623 2 241748836 241748864 29 + 0.588 0.833 1.014
ENSG00000180902 E021 12.2927283 0.0119529880 0.635505622 0.79391103 2 241748865 241748869 5 + 0.949 1.018 0.255
ENSG00000180902 E022 22.4901111 0.0355602806 0.983687609 0.99366977 2 241748870 241748942 73 + 1.241 1.251 0.036
ENSG00000180902 E023 12.1502764 0.0740287876 0.991492269 0.99753097 2 241748943 241748989 47 + 0.981 1.004 0.083
ENSG00000180902 E024 9.1280200 0.0977168725 0.654228926 0.80621526 2 241748990 241749008 19 + 0.946 0.880 -0.251
ENSG00000180902 E025 10.6926407 0.0550226811 0.567456904 0.74839147 2 241749009 241749100 92 + 0.870 0.974 0.393
ENSG00000180902 E026 18.7409145 0.1772706510 0.907868733 0.95607754 2 241749101 241749293 193 + 1.232 1.164 -0.241
ENSG00000180902 E027 7.3851153 0.1301440930 0.637922403 0.79567763 2 241749294 241749298 5 + 0.905 0.791 -0.439
ENSG00000180902 E028 13.9444480 0.1432099263 0.749491489 0.86646224 2 241749299 241749399 101 + 1.153 1.035 -0.424
ENSG00000180902 E029 28.1787980 0.3499806318 0.980770541 0.99213946 2 241749400 241749816 417 + 1.414 1.325 -0.312
ENSG00000180902 E030 12.4745357 0.0699221078 0.389809946 0.62031878 2 241749817 241749929 113 + 1.118 0.986 -0.484
ENSG00000180902 E031 9.7258225 0.1359730354 0.993551779 0.99840202 2 241749930 241750098 169 + 0.873 0.926 0.203
ENSG00000180902 E032 4.9935964 0.0058437707 0.688687506 0.82827105 2 241750099 241750150 52 + 0.725 0.665 -0.250
ENSG00000180902 E033 107.7923070 0.0092130728 0.571593246 0.75140648 2 241750151 241750294 144 + 1.933 1.906 -0.090
ENSG00000180902 E034 116.6868548 0.0034424079 0.897199779 0.95040850 2 241751246 241751388 143 + 1.947 1.947 0.002
ENSG00000180902 E035 6.2312874 0.0049629467 0.087199753 0.25860019 2 241751389 241751389 1 + 0.949 0.716 -0.913
ENSG00000180902 E036 11.4874550 0.0336691603 0.392099369 0.62211532 2 241754521 241754630 110 + 1.072 0.955 -0.431
ENSG00000180902 E037 20.3285669 0.1145406954 0.219178142 0.45241989 2 241754631 241754746 116 + 1.342 1.172 -0.600
ENSG00000180902 E038 11.8659459 0.1254112536 0.819405374 0.90775779 2 241755045 241755073 29 + 0.985 0.991 0.023
ENSG00000180902 E039 40.8539717 0.1430302434 0.867271027 0.93446883 2 241755074 241755609 536 + 1.513 1.493 -0.069
ENSG00000180902 E040 30.8043875 0.1003852771 0.864083746 0.93269425 2 241755610 241755848 239 + 1.377 1.378 0.005
ENSG00000180902 E041 124.9932608 0.0004619109 0.239343256 0.47584806 2 241755849 241756014 166 + 1.929 1.986 0.190
ENSG00000180902 E042 62.5038380 0.0047737010 0.167598971 0.38737730 2 241767710 241767712 3 + 1.591 1.689 0.334
ENSG00000180902 E043 385.5181991 0.0055069424 0.000648162 0.00698875 2 241767713 241768816 1104 + 2.343 2.477 0.449