ENSG00000180901

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322444 ENSG00000180901 HEK293_OSMI2_6hA HEK293_TMG_6hB KCTD2 protein_coding protein_coding 25.28772 35.59882 13.46155 4.331897 0.5624217 -1.402319 4.164202 3.648681 0.6397337 0.3463362 0.1783414 -2.493403 0.1845542 0.1033333 0.04846667 -0.05486667 2.672226e-01 5.464291e-08 FALSE TRUE
ENST00000375286 ENSG00000180901 HEK293_OSMI2_6hA HEK293_TMG_6hB KCTD2 protein_coding nonsense_mediated_decay 25.28772 35.59882 13.46155 4.331897 0.5624217 -1.402319 14.602752 25.117089 12.3222609 3.3783201 0.4904443 -1.026806 0.6228667 0.7082000 0.91556667 0.20736667 2.256747e-03 5.464291e-08 FALSE FALSE
ENST00000577516 ENSG00000180901 HEK293_OSMI2_6hA HEK293_TMG_6hB KCTD2 protein_coding processed_transcript 25.28772 35.59882 13.46155 4.331897 0.5624217 -1.402319 5.646381 5.516229 0.0000000 2.4061576 0.0000000 -9.110152 0.1572958 0.1489667 0.00000000 -0.14896667 5.464291e-08 5.464291e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000180901 E001 0.0000000       17 75032575 75032579 5 +      
ENSG00000180901 E002 0.0000000       17 75032580 75032599 20 +      
ENSG00000180901 E003 0.0000000       17 75032600 75032609 10 +      
ENSG00000180901 E004 0.0000000       17 75032610 75032611 2 +      
ENSG00000180901 E005 0.0000000       17 75032612 75032653 42 +      
ENSG00000180901 E006 0.0000000       17 75032654 75032724 71 +      
ENSG00000180901 E007 0.3447487 0.5424485975 9.085185e-01   17 75032725 75032930 206 + 0.000 0.140 9.617
ENSG00000180901 E008 0.5649788 0.0389474349 2.974910e-01   17 75032931 75033099 169 + 0.000 0.241 12.224
ENSG00000180901 E009 0.9704473 0.0156404214 1.346332e-01   17 75034033 75034117 85 + 0.000 0.326 13.099
ENSG00000180901 E010 0.8746386 0.0385711733 1.883987e-01   17 75034687 75034744 58 + 0.428 0.192 -1.597
ENSG00000180901 E011 2.8161534 0.1316445493 9.713187e-01 9.875015e-01 17 75035232 75035357 126 + 0.509 0.551 0.199
ENSG00000180901 E012 0.8102147 0.2139582517 1.559942e-01   17 75040124 75040463 340 + 0.426 0.139 -2.150
ENSG00000180901 E013 1.1733692 0.0141785863 5.056631e-01   17 75047184 75047224 41 + 0.193 0.326 1.001
ENSG00000180901 E014 1.9827761 0.0512803114 5.199205e-01 7.149523e-01 17 75047225 75047299 75 + 0.326 0.458 0.741
ENSG00000180901 E015 5.2430711 0.0049568133 2.200720e-01 4.536034e-01 17 75047300 75047418 119 + 0.579 0.780 0.848
ENSG00000180901 E016 98.6363518 0.0005044508 2.014455e-01 4.314986e-01 17 75047419 75047589 171 + 1.969 1.926 -0.146
ENSG00000180901 E017 0.0000000       17 75048843 75048957 115 +      
ENSG00000180901 E018 162.9742090 0.0002998892 3.746512e-03 2.772546e-02 17 75049220 75049328 109 + 2.211 2.130 -0.271
ENSG00000180901 E019 174.0238852 0.0004213374 9.828761e-04 9.782849e-03 17 75053014 75053105 92 + 2.245 2.154 -0.304
ENSG00000180901 E020 4.0648954 0.2540131631 9.859675e-01 9.948189e-01 17 75059123 75059509 387 + 0.631 0.656 0.104
ENSG00000180901 E021 177.2042046 0.0002792608 5.552094e-03 3.748254e-02 17 75059510 75059605 96 + 2.240 2.166 -0.247
ENSG00000180901 E022 4.2023887 0.0099306773 7.375374e-03 4.643391e-02 17 75059969 75060009 41 + 0.918 0.534 -1.587
ENSG00000180901 E023 189.0090010 0.0004448889 6.984943e-04 7.431890e-03 17 75062120 75062245 126 + 2.278 2.188 -0.303
ENSG00000180901 E024 1949.5159073 0.0002365112 6.927920e-12 6.140502e-10 17 75063018 75065889 2872 + 3.189 3.236 0.157